scholarly journals New Phenolic Glycosides from Securinega virosa and Their Antioxidant Activity

2009 ◽  
Vol 4 (12) ◽  
pp. 1934578X0900401
Author(s):  
Rokia Sanogo ◽  
Antonio Vassallo ◽  
Nicola Malafronte ◽  
Salvatore Imparato ◽  
Alessandra Russo ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Superoxide Anion ◽  
Flavonoid Glycoside ◽  
The Other ◽  
Scavenging Activity ◽  
Radical Scavengers ◽  
Phenolic Derivatives ◽  
Hydroxyl Radical Scavengers ◽  
Securinega Virosa

One new flavonoid glycoside, 3-O-kaempferol 4-O-(galloyl)-β-D-glucoside, one new bergenin derivative, 11-0-caffeoylbergenin, along with other known flavonoids and phenolic derivatives, were isolated from the leaves of Securinega virosa. Their structures were established on the basis of detailed spectral analysis. In vitro biological analysis of the isolated compounds showed that they were able to quench DPPH radicals and had a direct scavenging activity on superoxide anion. Kaempferol 3-O-(4-galloyl)-β-D-glucopyranoside (1), 11-0-caffeoylbergenin (2), and glucogallin (6) exhibited the highest antioxidant capacity, being also able to modulate hydroxyl radical formation more efficiently than the other compounds, acting as direct hydroxyl radical scavengers and chelating iron.

scholarly journals Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine

1983 ◽  
Vol 210 (1) ◽  
pp. 107-113 ◽  
Author(s):  
A I Cederbaum ◽  
E Dicker
Keyword(s):  
Hydroxyl Radical ◽  
Hydroxyl Radicals ◽  
Radical Scavenging ◽  
Chelating Agent ◽  
Dimethyl Sulphoxide ◽  
The Other ◽  
Radical Scavengers ◽  
Primary Alcohols ◽  
Hydroxyl Radical Scavengers ◽  
Oxidation Of Ethanol

Rat liver microsomes (microsomal fractions) catalyse the oxidation of straight-chain aliphatic alcohols and of hydroxyl-radical-scavenging agents during NADPH-dependent electron transfer. The iron-chelating agent desferrioxamine, which blocks the generation of hydroxyl radicals in other systems, was found to inhibit the following microsomal reactions: production of formaldehyde from either dimethyl sulphoxide or 2-methylpropan-2-ol (t-butylalcohol); generation of ethylene from 4-oxothiomethylbutyric acid; release of 14CO2 from [I-14C]benzoate; production of acetaldehyde from ethanol or butanal (butyraldehyde) from butan-1-ol. Desferrioxamine also blocked the increase in the oxidation of all these substrates produced by the addition of iron-EDTA to the microsomes. Desferrioxamine had no effect on a typical mixed-function-oxidase activity, the N-demethylation of aminopyrine, nor on the peroxidatic activity of catalase/H2O2 with ethanol. H2O2 appears to be the precursor of the oxidizing radical responsible for the oxidation of the alcohols and the other hydroxyl-radical scavengers. Chelation of microsomal iron by desferrioxamine most likely decreases the generation of hydroxyl radicals, which results in an inhibition of the oxidation of the alcohols and the hydroxyl-radical scavengers. Whereas desferrioxamine inhibited the oxidation of 2-methylpropan-2-ol, dimethyl sulphoxide, 4-oxothiomethylbutyrate and benzoate by more than 90%, the oxidation of ethanol and butanol could not be decreased by more than 45-60%. Higher concentrations of desferrioxamine were required to block the metabolism of the primary alcohols than to inhibit the metabolism of the other substrates. The desferrioxamine-insensitive rate of oxidation of ethanol was not inhibited by competitive hydroxyl-radical scavengers. These results suggest that primary alcohols may be oxidized by two pathways in microsomes, one dependent on the interaction of the alcohols with hydroxyl radicals (desferrioxamine-sensitive), the other which appears to be independent of these radicals (desferrioxamine-insensitive).

Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators

2008 ◽  
Vol 393 (3) ◽  
pp. 303-310 ◽  
Author(s):  
Mohammed R. Moussavian ◽  
Jan E. Slotta ◽  
Otto Kollmar ◽  
Michael D. Menger ◽  
Gernot Gronow ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Iron Chelators ◽  
Renal Tubules ◽  
Radical Scavengers ◽  
Hydroxyl Radical Scavengers

Role of hydroxyl radical scavengers dimethyl sulfoxide, alcohols and methional in the inhibition of prostaglandin biosynthesis

1976 ◽  
Vol 11 (4) ◽  
pp. 599-607 ◽  
Author(s):  
Rao V. Panganamala ◽  
Hari M. Sharma ◽  
Richard E. Heikkila ◽  
Jack C. Geer ◽  
David G. Cornwell
Keyword(s):  
Hydroxyl Radical ◽  
Dimethyl Sulfoxide ◽  
Radical Scavengers ◽  
Prostaglandin Biosynthesis ◽  
Hydroxyl Radical Scavengers

Evaluation of antioxidant activity of Melothria maderaspatana in vitro

2010 ◽  
Vol 5 (2) ◽  
pp. 224-230 ◽  
Author(s):  
Boobalan Raja ◽  
Kodukkur Pugalendi
Keyword(s):  
Hydrogen Peroxide ◽  
Antioxidant Activity ◽  
Free Radical ◽  
Hydroxyl Radical ◽  
Superoxide Anion ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Free Radical Scavenging ◽  
Melothria Maderaspatana

AbstractIn this study, an aqueous extract of leaves from Melothria maderaspatana was tested for in vitro antioxidant activity. Free radical scavenging assays, such as hydroxyl radical, hydrogen peroxide, superoxide anion radical and 2,2-diphenyl-1-picryl hydrazyl (DPPH), 2,2’-azinobis-(3-ethyl-enzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, and reducing power assay, were studied. The extract effectively scavenged hydroxyl radical, hydrogen peroxide and superoxide anion radicals. It also scavenged DPPH and ABTS radicals. Furthermore, it was found to have reducing power. All concentrations of leaf extract exhibited free radical scavenging and antioxidant power, and the preventive effects were in a dose-dependent manner. The antioxidant activities of the above were compared to standard antioxidants such as butylated hydroxytoluene (BHT), ascorbic acid, and α-tocopherol. The results obtained in the present study indicate that the M. maderaspatana extract could be considered a potential source of natural antioxidant.

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