Anti-Ulcerogenic Potential of Aqueous Extract of Securinega virosa Leaf in Indomethacin-Induced Ulcerated Rats

The anti-ulcerogenic activities of Securinega virosa aqueous leaf extract on gastric ulcer induced with indomethacin in albino rats were studied. Thirty rats weighing 120 - 200 g were grouped into six groups of five rats each. All groups except the uninduced-untreated (group A) were starved for 24 hours prior to indomethacin administration. After 4 hours of 30 mg kg-1 b.w. indomethacin administration, the groups (A, B, C, D, E and F) received once daily oral doses of distilled water (5ml kg-1 b.w.), cimetidine 60 mg kg-1 (b.w.) and the S. virosa extract at doses of 35, 70 and 140 mg kg-1 b.w. respectively for 11 days. At the end of the treatment, animals in groups B, C, D, E and F were starved for 18 hours then sacrificed. The extract significantly (p < 0.05) decreased gastric secretion volume, mean ulcer index, total acidity, total protein and pepsin secretion relative to the induced-untreated rats. The extract significantly (p < 0.05) increased the gastric pH and total carbohydrate content relative to the induced-untreated. These results were similar to those achieved by treatment with cimetidine. Catalase and SOD activities in the 35, 70 and 140 mg kg-1 bw S. virosa extract-treated groups were increased significantly (p < 0.05) over the untreated group. Similarly, the extract reversed the indomethacin-induced decrease in reduced glutathione level (GSSH) and the increase in malondialdehyde concentration in the serum. The histological analysis showed positive effect of the extract on the indomethacin-induced ulceration. It was concluded that the extract has anti-ulcerative and antioxidant activity in indomethacin-induced ulcerative rats.

Introduction Pages

Notulae Scientia Biologicae (http://www.notulaebiologicae.ro), Issue 2, Volume 11, 2019: The papers published in this issue (http://www.notulaebiologicae.ro/index.php/nsb/issue/current) represent interesting novelties in different topics of life science. Among the exciting researches, we invite readers to find news about: endophytic bacteria - hidden protective associates of plants against biotic and abiotic stresses (review); Occurrence of Salmonella in raw chicken meat from retail equipment and environments in southern Nigeria open markets; fruiting species influence the seasonal use of the habitat by sloth bear in and around Balaram Ambaji Wildlife Sanctuary, Gujarat, India; age susceptibility of wistar rats to alloxan-induced diabetes: a paradox; anti-ulcerogenic potential of aqueous extract of Securinega virosa leaf in indomethacin-induced ulcerated rats; evaluation of various biological activities of endemic Sideritis libanotica extracts; genetic polymorphism of the wild and in vitro regenerated plants of the medicinal grass Cymbopogon schoenanthus subsp. Proximus etc.