scholarly journals Bioactive Lignans from the Leaves and Stems of Schisandra wilsoniana

2013 ◽  
Vol 8 (4) ◽  
pp. 1934578X1300800
Author(s):  
Guang-Yu Yang ◽  
Rui-Rui Wang ◽  
Zhong-Hua Gao ◽  
Yin-Ke Li ◽  
Liu-Meng Yang ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Therapeutic Index ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Early Antigen ◽  
Barr Virus ◽  
Nmr Techniques ◽  
Epstein Barr ◽  
Anti Hiv ◽  
Hiv 1

Three new dibenzocyclooctadiene lignans, marlignans M–O (1–3), together two known ones, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1–3 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 2 showed anti-HIV-1 activity with an EC50 value of 5.82 μg/mL and a therapeutic index (TI) of more than 12.8. Compound 3 showed obvious bioactivity in inhibiting Epstein-Barr virus early antigen (EBV-EA) activation.

Inhibitory effects of 3-nitrophloroglucinecarboxylic acid derivatives on Epstein-Barr virus early antigen induction

1993 ◽  
Vol 68 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Ichiro Honda ◽  
Harukuni Tokuda ◽  
Mutsuo Kozuka ◽  
Koichi Yoneyama ◽  
Hoyoku Nishino ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Inhibitory Effects ◽  
Early Antigen ◽  
Barr Virus ◽  
Epstein Barr

Encephalitis in Infectious Mononucleosis: Diagnostic Considerations

PEDIATRICS ◽  
1976 ◽  
Vol 58 (6) ◽  
pp. 877-880
Author(s):  
Beverly J. Lange ◽  
Peter H. Berman ◽  
Joseph Bender ◽  
Werner Henle ◽  
John F. Hewetson
Keyword(s):  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Nuclear Antigen ◽  
Diffuse Component ◽  
Early Antigen ◽  
Barr Virus ◽  
Ebv Infection ◽  
Antibody Titers ◽  
Epstein Barr ◽  
Etiologic Diagnosis

Four atypical cases of presumed infectious mononucleosis (IM) encephalitis are presented. To establish an etiologic diagnosis, Paul-Bunnell-Davidsohn heterophil titers (PBD), antibody titers to the antigens of the Epstein-Barr virus (EBV), and oropharyngeal excretion of EBV were determined. Criteria for a primary EBV infection are (1) an antiviral capsid antigen titer of 1:160 or greater, (2) the presence of antibody to the diffuse component of the early antigen, (3) absence of antibody to the nuclear antigen, and (4) excretion of the virus from the oropharynx. Three of the four cases met these criteria; of the three, one did not have a positive heterophil titer. The fourth case turned out not to be IM; there was a positive PBD heterophil, but there was no evidence of primary EBV infection. Although the PBD heterophil is usually a reliable test to diagnosis IM, it is not always present in children, and it is sometimes nonspecifically elevated. Some EBV titers can be nonspecifically elevated as well; however, the above criteria are diagnostic of primary EBV infection.

scholarly journals Triterpenes from Maytenus macrocarpa and Evaluation of Their Anti-HIV Activity

2006 ◽  
Vol 1 (12) ◽  
pp. 1934578X0600101 ◽  
Author(s):  
Sonia Piacente ◽  
Lourdes Campaner Dos Santos ◽  
Naheed Mahmood ◽  
Cosimo Pizza
Keyword(s):  
Active Compound ◽  
2D Nmr ◽  
Selectivity Index ◽  
Spectroscopic Methods ◽  
Pentacyclic Triterpenes ◽  
Esi Ms ◽  
Ms Analysis ◽  
Anti Hiv ◽  
Hiv 1

A set of pentacyclic triterpenes has been isolated from the bark of Maytenus macrocarpa (Celastraceae). It includes two new olean-12-ene derivatives, namely 3β, 22α-dihydroxy-olean-12-en-30-oic acid (1) and 22α-hydroxy-olean-12-en-3-oxo-30-oic acid (2), and the new urs-12-ene derivative 3-(E)-coumaroyluvaol (7), along with 10 known compounds possessing olean-12-ene, urs-12-ene, lupane and friedelane skeletons. The structures have been elucidated by extensive spectroscopic methods including 1D- and 2D-NMR experiments, as well as ESI-MS analysis. All isolated compounds were tested for anti-HIV activity in C8166 cells infected with HIV-1MN. The most active compound was 22α-hydroxy-12-en-3-oxo-29-oic acid (triterpenonic acid A, 4), with an EC50 value of 1 μg/mL and a selectivity index of 35.

UNUSUAL PREVALENCE OF ANTIBODIES TO EPSTEIN-BARR VIRUS EARLY ANTIGEN IN ATAXIA TELANGIECTASIA

The Lancet ◽  
1977 ◽  
Vol 309 (8022) ◽  
pp. 1160 ◽  
Author(s):  
Jean Joncas ◽  
Normand Lapointe ◽  
Francine Gervais ◽  
Michele Leyritz ◽  
Adrian Wills
Keyword(s):  
Ataxia Telangiectasia ◽  
Epstein Barr Virus ◽  
Early Antigen ◽  
Barr Virus ◽  
Epstein Barr

Epstein-Barr Virus early antigen titer by immunofluorescence in microplates

1978 ◽  
Vol 166 (1-4) ◽  
pp. 209-217 ◽  
Author(s):  
A. M. Favart ◽  
M. E. Lamy ◽  
D. Allemeersch ◽  
G. Burtonboy ◽  
J. Vanoverschelde
Keyword(s):  
Epstein Barr Virus ◽  
Early Antigen ◽  
Barr Virus ◽  
Epstein Barr

New abietane diterpenoids from the cones of Larix kaempferi

2000 ◽  
Vol 78 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Hironori Ohtsu ◽  
Reiko Tanaka ◽  
Yasuko In ◽  
Shunyo Matsunaga ◽  
Harukuni Tokuda ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Tumor Promoter ◽  
Larix Kaempferi ◽  
Inhibitory Effects ◽  
Early Antigen ◽  
Barr Virus ◽  
Primary Screening ◽  
Abietane Diterpenoids ◽  
Epstein Barr ◽  
Abietane Diterpenes

A new podocarpane diterpene, 7α,15-dihydroxypodocarp-8(14)-en-13-one (1) and eight new abietane diterpenes, abiet-8(14)-en-7α,13β,15,18-tetraol (2), 7α,13β,15-trihydroxyabiet-8(14)-en-18-oic acid (3), 13β,18-dihydroxyabiet-8(14)-en-7-one (4), 13β,15,18-trihydroxyabiet-8(14)-en-7-one (5), 7-oxo-13β-methoxyabiet-8(14)- en-18-oic acid (7), abiet-8(14)-en-7α,12α,13β,18-tetraol (8), 7α,12α,13β-trihydroxyabiet-8(14)-en-18-oic acid (9), and abiet-8(14)-en-7α,12α,13β,15,18-pentaol (10) were isolated from the CHCl3 extract of the cones of Larix kaempferi. Their structures were determined on the basis of chemical and spectral evidence. The inhibitory effects of compounds 1-4 and 7-9 on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), were examined for a primary screening for anti-tumor promotors. Key words: Larix kaempferi, Pinaceae, cones, abietane, EBV-EA.

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