scholarly journals Two 2-Phenylbenzofuran Derivatives from Morus atropurpurea

2013 ◽  
Vol 8 (5) ◽  
pp. 1934578X1300800
Author(s):  
Wen-Jing Wang ◽  
Dong-Ling Wu ◽  
Sen-Tai Liao ◽  
Chun-Lin Fan ◽  
Li Guo-Qiang ◽  
...  
Keyword(s):  
Root Bark ◽  
Esi Ms ◽  
New Compounds

Two new 2-phenylbenzofuran derivatives, atrofuran A (1) and atrofuran B (2), along with five known compounds, were isolated from the root bark of Morus atropurpurea. The structures of the new compounds were determined on the basis of extensive NMR spectroscopic and HR-ESI-MS analyses.

scholarly journals Two New Compounds from Artemisia sacrorum

2016 ◽  
Vol 11 (4) ◽  
pp. 1934578X1601100
Author(s):  
Qinghu Wang ◽  
Rongjun Wu ◽  
Narenchaoketu Han ◽  
Nayintai Dai ◽  
Jiesi Wu
Keyword(s):  
Structure Elucidation ◽  
2D Nmr ◽  
Etoac Extract ◽  
First Report ◽  
Esi Ms ◽  
New Compounds

Two new compounds, named as sacric acid A (1) and sacric acid B (2), were isolated from the EtOAc extract of Artemisia sacrorum Ledeb. This is the first report on the structure elucidation of these compounds based on UV, IR, and extensive 1D and 2D NMR spectroscopic, and ESI-MS techniques.

scholarly journals Secondary metabolites of Phlebopus species from Northern Thailand

2020 ◽  
Vol 19 (12) ◽  
pp. 1525-1536
Author(s):  
Boontiya Chuankid ◽  
Hedda Schrey ◽  
Benjarong Thongbai ◽  
Olivier Raspé ◽  
Norbert Arnold ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
2D Nmr ◽  
Cytotoxic Activities ◽  
Tumor Cell Lines ◽  
Submerged Cultures ◽  
Esi Ms ◽  
Spectroscopic Analyses ◽  
New Compounds ◽  
Comprehensive Characterization

AbstractSubmerged cultures of the edible mushrooms Phlebopus portentosus and Phlebopus spongiosus were screened for their secondary metabolites by HPLC-UV/Vis and HR-LC-ESI-MS. Two new compounds, 9′-hydroxyphenyl pulvinone (1), containing an unusual pulvinone structure, and phlebopyron (2), together with the seven known pigments, atromentic acid (3), xerocomic acid (4), variegatic acid (5), methyl atromentate (6), methyl isoxerocomate (7), methyl variegatate (8), and variegatorubin (9) were isolated from the cultures. Their structures were assigned on the basis of extensive 1D/2D NMR spectroscopic analyses, as well as HR-ESI-MS, and HR-ESI-MS/MS measurements. Furthermore, the isolated compounds were evaluated for their antimicrobial and cytotoxic properties. 9′-hydroxyphenyl pulvinone (1), xerocomic acid (4), and methyl variegatate (8) exhibited weak to moderate cytotoxic activities against several tumor cell lines. The present paper provides a comprehensive characterization of pigments from the class of pulvinic acids that are present in the basidiomes of many edible bolete species.

scholarly journals Synthesis and characterization of new 4-aryl-2-(2-oxopropoxy)-6-(2,5-dichlorothiophene)nicotinonitrile and their furo[2,3-b]pyridine derivatives: Assessment of antioxidant and biological activity

2018 ◽  
Vol 9 (4) ◽  
pp. 375-381 ◽  
Author(s):  
Mahmoud Al‐Refai ◽  
Mohammad Ibrahim ◽  
Abdullah Al‐Fawwaz ◽  
Armin Geyer
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Pyridine Derivatives ◽  
Esi Ms ◽  
Scavenging Effect ◽  
Radical Scavenging Effect ◽  
New Compounds

A new series of furo[2,3-b]pyridine derivatives bearing aryl substituents were synthesized in two steps, where, the cyano-(2H)-pyridones (1a-l) were converted to the corresponding nicotinonitriles (2a-l), followed by the Thorpe-Ziegler ring cyclization to the furo[2,3-b]pyridine derivatives (3a-l). All new compounds were characterized by 1D-NMR experiments (1H and 13C) and 2D-NMR experiments (COSY, HMBC and HSQC), as well as ESI-MS and HR-ESI-MS data. The new compounds were screened for their antioxidant activities by 2,2-diphenyl-1-picryl-hydrazylhydrate (DPPH) free radical assay. The highest radical scavenging effect was observed for nicotinonitriles 2d, 2h and 2l and furo[2,3-b]pyridines 3b, 3f and 3j by methanolic solvent at 4.0 mg/mL concentration. Remarkably, all nicotinonitriles and furo[2,3-b]pyridine exhibited a significant radical scavenging activity after 24 and 48 hours compared with 0.5 hour.

scholarly journals Novel Decaturin Alkaloids from the Marine-Derived Fungus Penicillium Oxalicum

2013 ◽  
Vol 8 (10) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Pei-le Wang ◽  
Dan-yi Li ◽  
Lei-rui Xie ◽  
Xin Wu ◽  
Hui-ming Hua ◽  
...  
Keyword(s):  
2D Nmr ◽  
Penicillium Oxalicum ◽  
Nmr Analysis ◽  
Esi Ms ◽  
New Compounds

From the mycelia of Penicillium oxalicum two new compounds, decaturins E (1) and F (2), have been isolated, along with four known analogues, decaturin A (3), decaturin C (4), decaturin D (5), and oxalicine B (6). The structures were determined by HR-ESI-MS and 1D and 2D NMR analysis.

scholarly journals Cytotoxic Prenylated Polyphenolic Compounds from Maackia amurensis Root Bark

2017 ◽  
Vol 12 (7) ◽  
pp. 1934578X1701200
Author(s):  
Marina V. Veselova ◽  
Sergey A. Fedoreyev ◽  
Darya V. Tarbeeva ◽  
Nadezda I. Kulesh ◽  
Anatoliy I. Kalinovskiy ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Hela Cells ◽  
Human Cancer ◽  
Polyphenolic Compounds ◽  
Root Bark ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Maackia Amurensis ◽  
New Compounds

Two new prenylated flavanones, isomaackiaflavanone A (1), isomaackiaflavanone B (2) and a new prenylated stilbene maackiastilbene (3), along with five known flavanones were isolated from the root bark of Maackia amurensis using repeated column chromatography on silica gel, Sephadex LH-20 and octadecyl silica (ODS-A) sorbents. The structures of the new compounds were elucidated by HPLC–PDA–MS, HR-ESI-MS, 1H, 13C, 1H–1H COSY, HSQC, ROESY and HMBC NMR analyses. The cytotoxicity of compounds 1–2, 4–8 against two human cancer cell lines HeLa and SK-MEL-5 was tested using the MTS method. Compounds 4, 6 and 8 showed the strongest cytotoxic activity among the compounds tested with IC50 values of 6.5, 8.8 and 7.7 μM, against SK-MEL-5 cells and 8.2, 18.8 and 12 μM against HeLa cells, respectively.

scholarly journals Two New Compounds from Paeonia lactiflora

2015 ◽  
Vol 10 (2) ◽  
pp. 1934578X1501000
Author(s):  
QingHu Wang ◽  
Nayintai Dai ◽  
Narenchaoketu Han ◽  
Wuliji Ao
Keyword(s):  
Ethanol Extract ◽  
2D Nmr ◽  
Diethyl Ester ◽  
Spectroscopic Methods ◽  
Paeonia Lactiflora ◽  
Esi Ms ◽  
Nmr Techniques ◽  
New Compounds

Two new compounds, namely 5-methyl-4,2′,3′,5′-tetrahydroxy-4′-methoxy-2-aldehyde biphenyl (1) and 1,8-dioxo-1,8-dihydropyrano[3,4-c]pyran-3,6-dicarboxyl acid, diethyl ester (2), were isolated from the 95% ethanol extract of the roots of Paeonia lactiflora Pall. The structures of 1 and 2 were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

scholarly journals HPLC/MS-MS Identification of Oak Quercus aegilops Root Tannins

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Ayed S. Amr ◽  
Mousa N. Ahmad ◽  
Jalal A. Zahra ◽  
Mai A. Abdullah
Keyword(s):  
Ellagic Acid ◽  
Acid Ester ◽  
Polyphenolic Compounds ◽  
Root Bark ◽  
Biological Functions ◽  
Plant Kingdom ◽  
Esi Ms ◽  
Oak Tree ◽  
Common Oak ◽  
Ms Search

Tannins are natural polyphenolic compounds widely distributed in the plant kingdom in the leaves, bark, fruits, and other parts. They have various biological functions in humans and animals and are used mainly in the pharmaceutical and cosmetic industries. The aim of this work was to isolate, extract, purify, and identify the tannins from the root bark of a common oak tree (Quercus aegilops L.) in Jordan and around the Mediterranean. The results showed that at least one form of ellagitannin (ellagic acid ester), quercitrin, afzelechin, valoneic acid, trigalloyl glucose, and catechin was identified in addition to two unidentified compounds. Results of this work can help in developing an ESI MS/MS search library for the constituents of the tannins of oak (Quercus aegilops L.) root bark.

New Isoflavonoids from Root Bark of Kowhai Sophora microphylla)

1997 ◽  
Vol 50 (4) ◽  
pp. 333 ◽  
Author(s):  
Graeme B. Russell Horticultural
Keyword(s):  
Spectroscopic Analysis ◽  
Root Bark ◽  
New Compounds

Two new isoflavanones, phyllanone A (1) and phyllanone B (2), together with the known isoflavonoids isosophoranone (3), maackiain (4), medicagol (5) and lupalbigenin (6), have been isolated from the root bark ofSophora microphylla. The structures and chirality of the new compounds have been determined from spectroscopic analysis.

Three new compounds from the dried root bark of Wikstroemia indica and their cytotoxicity against HeLa cells

2021 ◽  
pp. 1-8
Author(s):  
Peixin Shi ◽  
Zhihui Liu ◽  
Ruyue Cen ◽  
Caihui Mao ◽  
Na Han ◽  
...  
Keyword(s):  
Hela Cells ◽  
Root Bark ◽  
New Compounds
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