Ushikulide C, a New Immunosuppressant from Streptomyces sp. IUK-102

Ushikulide C (1), a new immunosuppressant, was isolated from the culture broth of Streptomyces sp. IUK-102. The structure of 1 is a new 22-membered macrolide that is related to ushikulides A (2) and B (3). The immunosuppressive activity of 1 on murine splenocyte proliferation in vitro was comparable with those of 2 and 3.

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An antisense oligodeoxynucleotide complementary to corticotropin-releasing hormone mRNA inhibits rat splenocyte proliferation in vitro

Journal of Neuroimmunology ◽

10.1016/s0165-5728(97)00011-8 ◽

1997 ◽

Vol 75 (1-2) ◽

pp. 135-140 ◽

Cited By ~ 17

Author(s):

D.S Jessop ◽

M.S Harbuz ◽

C.L Snelson ◽

C.M Dayan ◽

S.L Lightman

Keyword(s):

Antisense Oligodeoxynucleotide ◽

Splenocyte Proliferation ◽

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Proliferation In Vitro

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Polychlorinated biphenyl mixtures (Aroclors) inhibit LPS-induced murine splenocyte proliferation in vitro

Toxicology ◽

10.1016/s0300-483x(99)00118-3 ◽

1999 ◽

Vol 139 (1-2) ◽

pp. 137-154 ◽

Cited By ~ 30

Author(s):

Allison Schulze Stack ◽

Sanja Altman-Hamamdzic ◽

Pamela J. Morris ◽

Steven D. London ◽

Lucille London

Keyword(s):

Polychlorinated Biphenyl ◽

Splenocyte Proliferation ◽

Proliferation In Vitro

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Dietary Deprivation of B-Vitamins Reflected in Murine Splenocyte Proliferation in Vitro

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1994.1066 ◽

1994 ◽

Vol 198 (2) ◽

pp. 451-458 ◽

Cited By ~ 3

Author(s):

K.S. Matthews ◽

E. Mrowczynski ◽

R. Matthews

Keyword(s):

B Vitamins ◽

Splenocyte Proliferation ◽

Proliferation In Vitro

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No evidence that rifampicin has glucocorticoid-like immunosuppressive properties leading to suppression of rat-splenocyte proliferation in vitro

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/47.6.894 ◽

2001 ◽

Vol 47 (6) ◽

pp. 894-895 ◽

Cited By ~ 3

Author(s):

J. Visser

Keyword(s):

Splenocyte Proliferation ◽

Proliferation In Vitro

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Purification and Characterization of the Lectin from Taro (Colocasia esculenta) and Its Effect on Mouse Splenocyte Proliferation In Vitro and In Vivo

The Protein Journal ◽

10.1007/s10930-013-9541-y ◽

2014 ◽

Vol 33 (1) ◽

pp. 92-99 ◽

Cited By ~ 16

Author(s):

Patrícia Ribeiro Pereira ◽

Eduardo Mere Del Aguila ◽

Maurício Afonso Verícimo ◽

Russolina Benedeta Zingali ◽

Vânia Margaret Flosi Paschoalin ◽

...

Keyword(s):

Colocasia Esculenta ◽

Splenocyte Proliferation ◽

Purification And Characterization ◽

Proliferation In Vitro

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1442: CXCL12 Over-Expression and Secretion by Aging Fibroblasts Stimulates Human Prostate Epithelial Proliferation in Vitro

The Journal of Urology ◽

10.1016/s0022-5347(18)33646-2 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 466-466

Author(s):

Jill A. Macoska ◽

Lesa Begley ◽

Christine Monteleon ◽

James W. MacDonald ◽

Rajal B. Shah

Keyword(s):

Human Prostate ◽

Epithelial Proliferation ◽

Over Expression ◽

Proliferation In Vitro

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Age-Related Changes in the Effects of Serum from Lean and Obese Pigs on Myogenic Cell Proliferation in Vitro

Journal of Animal Science ◽

10.2527/jas1982.544763x ◽

1982 ◽

Vol 54 (4) ◽

pp. 763-768 ◽

Cited By ~ 3

Author(s):

Ronald E. Allen ◽

Gail Robinson ◽

Matthew J. Parsons ◽

Robert A. Merkel ◽

William T. Magee

Keyword(s):

Cell Proliferation ◽

Myogenic Cell ◽

Age Related ◽

Proliferation In Vitro ◽

Age Related Changes

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Micro/nano-textured hierarchical titanium topography promotes exosome biogenesis and secretion to improve osseointegration

Journal of Nanobiotechnology ◽

10.1186/s12951-021-00826-3 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Zhengchuan Zhang ◽

Ruogu Xu ◽

Yang Yang ◽

Chaoan Liang ◽

Xiaolin Yu ◽

...

Keyword(s):

Gene Expression ◽

Titanium Surface ◽

Titanium Implants ◽

Extracellular Secretion ◽

Exosome Biogenesis ◽

Marrow Mesenchymal Stem Cells ◽

Proliferation In Vitro ◽

Extracellular Environment

Abstract Background Micro/nano-textured hierarchical titanium topography is more bioactive and biomimetic than smooth, micro-textured or nano-textured titanium topographies. Bone marrow mesenchymal stem cells (BMSCs) and exosomes derived from BMSCs play important roles in the osseointegration of titanium implants, but the effects and mechanisms of titanium topography on BMSCs-derived exosome secretion are still unclear. This study determined whether the secretion behavior of exosomes derived from BMSCs is differently affected by different titanium topographies both in vitro and in vivo. Results We found that both micro/nanonet-textured hierarchical titanium topography and micro/nanotube-textured hierarchical titanium topography showed favorable roughness and hydrophilicity. These two micro/nano-textured hierarchical titanium topographies enhanced the spreading areas of BMSCs on the titanium surface with stronger promotion of BMSCs proliferation in vitro. Compared to micro-textured titanium topography, micro/nano-textured hierarchical titanium topography significantly enhanced osseointegration in vivo and promoted BMSCs to synthesize and transport exosomes and then release these exosomes into the extracellular environment both in vitro and in vivo. Moreover, micro/nanonet-textured hierarchical titanium topography promoted exosome secretion by upregulating RAB27B and SMPD3 gene expression and micro/nanotube-textured hierarchical titanium topography promoted exosome secretion due to the strongest enhancement in cell proliferation. Conclusions These findings provide evidence that micro/nano-textured hierarchical titanium topography promotes exosome biogenesis and extracellular secretion for enhanced osseointegration. Our findings also highlight that the optimized titanium topography can increase exosome secretion from BMSCs, which may promote osseointegration of titanium implants.

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