Age-Related Changes in the Effects of Serum from Lean and Obese Pigs on Myogenic Cell Proliferation in Vitro

1982 ◽  
Vol 54 (4) ◽  
pp. 763-768 ◽  
Author(s):  
Ronald E. Allen ◽  
Gail Robinson ◽  
Matthew J. Parsons ◽  
Robert A. Merkel ◽  
William T. Magee
Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1473
Author(s):  
Belal I. Hanafy ◽  
Gareth W. V. Cave ◽  
Yvonne Barnett ◽  
Barbara K. Pierscionek

Cerium oxide nanoparticles (nanoceria) are generally known for their recyclable antioxidative properties making them an appealing biomaterial for protecting against physiological and pathological age-related changes that are caused by reactive oxygen species (ROS). Cataract is one such pathology that has been associated with oxidation and glycation of the lens proteins (crystallins) leading to aggregation and opacification. A novel coated nanoceria formulation has been previously shown to enter the human lens epithelial cells (HLECs) and protect them from oxidative stress induced by hydrogen peroxide (H2O2). In this work, the mechanism of nanoceria uptake in HLECs is studied and multiple anti-cataractogenic properties are assessed in vitro. Our results show that the nanoceria provide multiple beneficial actions to delay cataract progression by (1) acting as a catalase mimetic in cells with inhibited catalase, (2) improving reduced to oxidised glutathione ratio (GSH/GSSG) in HLECs, and (3) inhibiting the non-enzymatic glucose-induced glycation of the chaperone lens protein α-crystallin. Given the multifactorial nature of cataract progression, the varied actions of nanoceria render them promising candidates for potential non-surgical therapeutic treatment.


2002 ◽  
Vol 266 (4) ◽  
pp. 223-228 ◽  
Author(s):  
Seung Yup Ku ◽  
Y. M. Choi ◽  
Chang Suk Suh ◽  
Seok Hyun Kim ◽  
Jung Gu Kim ◽  
...  

2011 ◽  
Vol 14 (9) ◽  
pp. 1023-1031 ◽  
Author(s):  
Satyakumar Vidyashankar ◽  
Sandeep R. Varma ◽  
Mohammed Azeemudin ◽  
Ashok Godavarthi ◽  
Nandakumar S. Krishna ◽  
...  

2005 ◽  
Vol 16 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Evaggelia S. Arsenou ◽  
Evangelia P. Papadimitriou ◽  
Eleni Kliafa ◽  
Maria Hountala ◽  
Sotiris S. Nikolaropoulos

1997 ◽  
Vol 51 (6) ◽  
pp. 1838-1846 ◽  
Author(s):  
Masashi Haraguchi ◽  
Mikio Okamura ◽  
Masayo Konishi ◽  
Yoshio Konishi ◽  
Nobuo Negoro ◽  
...  

2014 ◽  
Vol 51 (4) ◽  
pp. 372-380 ◽  
Author(s):  
Sureshbabu Ram Kumar Pandian ◽  
Venkataraman Deepak ◽  
Hariharan Nellaiah ◽  
Krishnan Sundar

2004 ◽  
Vol 78 ◽  
pp. 741-742
Author(s):  
I Rama ◽  
M Riera ◽  
J Torras ◽  
J M Cruzado ◽  
I Herrero-Fresneda ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document