scholarly journals Hedyotis diffusa Water Extract Diminished the Cytotoxic Effects of Chemotherapy Drugs against Human Breast Cancer MCF7 Cells

2014 ◽  
Vol 9 (5) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Qiulin Dong ◽  
Binbing Ling ◽  
Bosong Gao ◽  
Jason Maley ◽  
Ramaswami Sammynaiken ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Herbal Medicines ◽  
Water Extract ◽  
Therapeutic Effects ◽  
Human Breast ◽  
Mcf7 Cells ◽  
Chemotherapy Drugs ◽  
Hedyotis Diffusa ◽  
Iridoid Glucosides

Hedyotis diffusa is a Chinese herbal medicine widely used in combination with other herbal medicines such as Scutellaria barbata to treat various types of cancer. Late-stage and recurrent cancer patients usually use H. diffusa during chemotherapy in expecting to achieve additive or synergistic therapeutic effects. Several classes of active ingredients, including anthraquinones, iridoid glucosides and stigmasterols, have been isolated and characterized from H. diffusa. In the current study, we isolated alkaloid/flavonoid from H. diffusa and showed that the crude alkaloid/flavonoid extract rather than its three major components possessed antitumor activity against human breast cancer cell line MCF7. Co-administration of H. diffusa water extract diminished the cytotoxicities of chemotherapy drugs doxorubicin, cyclophosphamide and docetaxel towards the MCF7 cells, implicating that H. diffusa should not be used during breast cancer chemotherapy.

Crosstalk among ROS, Epigenetics and TPA-Induced EMT in Human Breast Cancer MCF7 Cells

2014 ◽  
Vol 76 ◽  
pp. S128
Author(s):  
Tetsuro Kamiya ◽  
Aki Goto ◽  
Hirokazu Hara ◽  
Tetsuo Adachi
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mcf7 Cells

scholarly journals β-Carboline copper complex as a potential mitochondrial-targeted anticancer chemotherapeutic agent: Favorable attenuation of human breast cancer MCF7 cells via apoptosis

2020 ◽  
Vol 27 (8) ◽  
pp. 2164-2173
Author(s):  
Rais Ahmad Khan ◽  
Mohammad Rashid Khan ◽  
Mohammad Usman ◽  
Fatima Sayeed ◽  
Huda A. Alghamdi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Copper Complex ◽  
Human Breast Cancer ◽  
Chemotherapeutic Agent ◽  
Human Breast ◽  
Mcf7 Cells

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

2012 ◽  
Vol 76 (7) ◽  
pp. 1322-1328 ◽  
Author(s):  
Chaoqing HUANG ◽  
Xiaoguang CHEN ◽  
Baolin GUO ◽  
Wenhua HUANG ◽  
Ting SHEN ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mcf7 Cells ◽  
Icariside Ii ◽  
Induction Of Apoptosis

Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells

2006 ◽  
Vol 36 (8) ◽  
pp. 588-596 ◽  
Author(s):  
C. J. Chang ◽  
J. H. Chiu ◽  
L. M. Tseng ◽  
C. H. Chang ◽  
T. M. Chien ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ferulic Acid ◽  
Human Breast Cancer ◽  
Her2 Expression ◽  
Human Breast ◽  
Mcf7 Cells

scholarly journals Androgen-Induced Inhibition of Proliferation in Human Breast Cancer MCF7 Cells Transfected with Androgen Receptor*

Endocrinology ◽  
1997 ◽  
Vol 138 (4) ◽  
pp. 1406-1412 ◽  
Author(s):  
Jozsef Szelei ◽  
Jesus Jimenez ◽  
Ana M. Soto ◽  
Maria F. Luizzi ◽  
Carlos Sonnenschein
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mcf7 Cells ◽  
Inhibition Of Proliferation
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