scholarly journals Evaluating the Anticancer Activity of Hedyotis diffusa Water Extract Against Human Breast Cancer MCF7 Cells

2013 ◽  
Vol 6 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Binbing Ling
2014 ◽  
Vol 9 (5) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Qiulin Dong ◽  
Binbing Ling ◽  
Bosong Gao ◽  
Jason Maley ◽  
Ramaswami Sammynaiken ◽  
...  

Hedyotis diffusa is a Chinese herbal medicine widely used in combination with other herbal medicines such as Scutellaria barbata to treat various types of cancer. Late-stage and recurrent cancer patients usually use H. diffusa during chemotherapy in expecting to achieve additive or synergistic therapeutic effects. Several classes of active ingredients, including anthraquinones, iridoid glucosides and stigmasterols, have been isolated and characterized from H. diffusa. In the current study, we isolated alkaloid/flavonoid from H. diffusa and showed that the crude alkaloid/flavonoid extract rather than its three major components possessed antitumor activity against human breast cancer cell line MCF7. Co-administration of H. diffusa water extract diminished the cytotoxicities of chemotherapy drugs doxorubicin, cyclophosphamide and docetaxel towards the MCF7 cells, implicating that H. diffusa should not be used during breast cancer chemotherapy.


2014 ◽  
Vol 76 ◽  
pp. S128
Author(s):  
Tetsuro Kamiya ◽  
Aki Goto ◽  
Hirokazu Hara ◽  
Tetsuo Adachi

2017 ◽  
Vol 11 (8) ◽  
pp. 965-972 ◽  
Author(s):  
Ramasamy Subbaiya ◽  
Muthupandian Saravanan ◽  
Andavar Raja Priya ◽  
Konathala Ravi Shankar ◽  
Masilamani Selvam ◽  
...  

2020 ◽  
Vol 27 (8) ◽  
pp. 2164-2173
Author(s):  
Rais Ahmad Khan ◽  
Mohammad Rashid Khan ◽  
Mohammad Usman ◽  
Fatima Sayeed ◽  
Huda A. Alghamdi ◽  
...  

2012 ◽  
Vol 76 (7) ◽  
pp. 1322-1328 ◽  
Author(s):  
Chaoqing HUANG ◽  
Xiaoguang CHEN ◽  
Baolin GUO ◽  
Wenhua HUANG ◽  
Ting SHEN ◽  
...  

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