scholarly journals Isolation, Structural Characterization and Neurotrophic Activity of Alkylamides from Zanthoxylum bungeanum

2017 ◽  
Vol 12 (7) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Yuan Wang ◽  
Zhong-Bin Liao ◽  
Rong Cao ◽  
He Li ◽  
An-Zhi Wei ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Structural Characterization ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Pc 12 Cells ◽  
Neurotrophic Activity ◽  
Fatty Acid Amides ◽  
Zanthoxylum Bungeanum

Two new fatty acid amides, zanthoamides E (1) and F (2), were isolated from the pericarps of Zanthoxylum bungeanum. The structures of the two sanshool compounds were elucidated by analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). All isolated compounds (1–9) were evaluated for nerve growth factor (NGF)-potentiating activity using PC-12 cells, and the results indicated that compound 8 (tetrahydrobungeanool) showed the strongest neurotrophic activity.

Dietary n-3 fatty acid deficiency decreases nerve growth factor content in rat hippocampus

2000 ◽  
Vol 285 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Atsushi Ikemoto ◽  
Atsumi Nitta ◽  
Shoei Furukawa ◽  
Masayo Ohishi ◽  
Akira Nakamura ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Rat Hippocampus ◽  
Factor Content ◽  
Nerve Growth ◽  
Acid Deficiency ◽  
Fatty Acid Deficiency

scholarly journals Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells.

1988 ◽  
Vol 263 (12) ◽  
pp. 5662-5667
Author(s):  
M H Lindenbaum ◽  
S Carbonetto ◽  
F Grosveld ◽  
D Flavell ◽  
W E Mushynski
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Pc 12 Cells

scholarly journals Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Gallant K. L. Chan ◽  
Winnie W. H. Hu ◽  
Zoey X. Zheng ◽  
M. Huang ◽  
Yan X. Y. Lin ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Drug Development ◽  
Ginkgo Biloba ◽  
Water Extract ◽  
Herbal Extract ◽  
Herbal Extracts ◽  
Mental Processes ◽  
Pc 12 Cells ◽  
Excellent Source

Dementia is a persistent disorder of the mental processes and is strongly related to depression. However, the performance of current antidepression medicine is far from satisfactory. Herbal extract provides an excellent source to identify compounds for possible drug development against depression. Here, HerboChips were employed to search herbal compounds that could bind nerve growth factor (NGF). By screening over 500 types of herbal extracts, the water extract of Ginkgo Folium, the leaf of Ginkgo biloba, showed a strong binding to NGF. The herbal fractions showing NGF binding were further isolated and enriched. By using LC-MS/MS analysis, one of the NGF binding fractions was enriched, which was further identified as quercetin, a major flavonoid in Ginkgo Folium. Quercetin, similar to Ginkgo Folium extract, could enhance the effect of NGF in cultured PC 12 cells, including potentiation of neurite outgrowth and phosphorylation of Erk-1/2. This is the first report of discovering an NGF binding compound by using HerboChips from herbal extracts, which could be further developed for antidepression application.

scholarly journals Neuritogenesis and the Nerve Growth Factor-induced Differentiation of PC-12 Cells Requires Annexin II-mediated Plasmin Generation

2001 ◽  
Vol 276 (52) ◽  
pp. 49350-49358 ◽  
Author(s):  
Andrew T. Jacovina ◽  
Fengming Zhong ◽  
Elena Khazanova ◽  
Emil Lev ◽  
Arunkumar B. Deora ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Annexin Ii ◽  
Induced Differentiation ◽  
Nerve Growth ◽  
Pc 12 Cells
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