scholarly journals (+)-Pathylactone A, a New Natural Nor-sesquiterpenoid from the Octocoral Paralemnalia thyrsoides

2018 ◽  
Vol 13 (1) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Zhi-Jun Zhang ◽  
Wu-Fu Chen ◽  
Bo-Rong Peng ◽  
Zhi-Hong Wen ◽  
Ping-Jyun Sung
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cell Line ◽  
Spectral Data ◽  
Inducible Nitric Oxide Synthase ◽  
Spectroscopic Methods ◽  
Murine Macrophage ◽  
Synthetic Analogues ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

A new natural marine nor-sesquiterpenoid, (+)-pathylactone A (1), along with a know nor-sesquiterpenoid, napalilactoe (2), were isolated from the octocoral Paralemnalia thyrsoides. The structure of 1 was established on the basis of spectroscopic methods and by comparison of the spectral data with those of synthetic analogues. Nor-sesquiterpenoid 1 was found to inhibit the protein experssion of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line.

Prostaglandin E2 regulates inducible nitric oxide synthase in the murine macrophage cell line J774

1995 ◽  
Vol 49 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Salvatore Milano ◽  
Francesco Arcoleo ◽  
Mariella Dieli ◽  
Rita D'Agostino ◽  
Pietro D'Agostino ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Prostaglandin E2 ◽  
Cell Line ◽  
Inducible Nitric Oxide Synthase ◽  
Murine Macrophage ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Effects of short chain alkanols on the inducible nitric oxide synthase in a glial cell line

1999 ◽  
Vol 126 (5) ◽  
pp. 1253-1261 ◽  
Author(s):  
Peter J Syapin ◽  
Alexia Rendon ◽  
David R Huron ◽  
Julius D Militante
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cell Line ◽  
Glial Cell ◽  
Inducible Nitric Oxide Synthase ◽  
Short Chain ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Fragilides U–W: New 11,20-Epoxybriaranes from the Sea Whip Gorgonian Coral Junceella fragilis

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 706 ◽  
Author(s):  
Tung-Pin Su ◽  
Chien-Han Yuan ◽  
Yi-Ming Jhu ◽  
Bo-Rong Peng ◽  
Zhi-Hong Wen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Spectroscopic Methods ◽  
Gorgonian Coral ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Three new 11,20-epoxybriaranes—fragilides U–W (1–3), as well as two known metabolites, junceellonoid D (4) and junceellin (5), were obtained from the octocoral Junceella fragilis. The structures of briaranes 1–3 were elucidated by spectroscopic methods and briaranes 3 and 5 displayed inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW264.7.

Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells

1998 ◽  
Vol 275 (5) ◽  
pp. E740-E747 ◽  
Author(s):  
Sidney M. Morris ◽  
Diane Kepka-Lenhart ◽  
Li-Chun Chen
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Interferon Γ ◽  
Inos Expression ◽  
Murine Macrophage ◽  
Arginase Ii ◽  
Oxide Synthase ◽  
Arginase I ◽  
Inducible Nitric Oxide

Activated macrophages avidly consume arginine via the action of inducible nitric oxide synthase (iNOS) and/or arginase. In contrast to our knowledge regarding macrophage iNOS expression, the stimuli and mechanisms that regulate expression of the cytosolic type I (arginase I) or mitochondrial type II (arginase II) isoforms of arginase in macrophages are poorly defined. We show that one or both arginase isoforms may be induced in the RAW 264.7 murine macrophage cell line and that arginase expression is regulated independently of iNOS expression. For example, 8-bromo-cAMP strongly induced both arginase I and II mRNAs but not iNOS. Whereas interferon-γ induced iNOS but not arginase, 8-bromo-cAMP and interferon-γ mutually antagonized induction of iNOS and arginase I mRNAs. Dexamethasone, which did not induce either arginase or iNOS, almost completely abolished induction of arginase I mRNA by 8-bromo-cAMP but enhanced induction of arginase II mRNA. Lipopolysaccharide (LPS) induced arginase II mRNA, but 8-bromo-cAMP plus LPS resulted in synergistic induction of both arginase I and II mRNAs. In all cases, increases in arginase mRNAs were sufficient to account for the increases in arginase activity. These complex patterns of expression suggest that the arginase isoforms may play distinct, although partially overlapping, functional roles in macrophage arginine metabolism.

scholarly journals Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908)

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 383
Author(s):  
Yi-Lin Zhang ◽  
Chih-Chao Chiang ◽  
Yi-Ting Lee ◽  
Zhi-Hong Wen ◽  
Yang-Chang Wu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Chemical Study ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Oxide Synthase ◽  
Continuous Chemical ◽  
Inducible Nitric Oxide ◽  
New Metabolites

Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (1–4). The structures of new metabolites 1–4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).

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