scholarly journals Network Pharmacological Dissection of the Mechanisms of Eucommiae Cortex-Achyranthis Radix Combination for Intervertebral Disc Herniation Treatment

2021 ◽  
Vol 16 (10) ◽  
pp. 1934578X2110550
Author(s):  
Ho-Sung Lee ◽  
In-Hee Lee ◽  
Kyungrae Kang ◽  
Minho Jung ◽  
Seung Gu Yang ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Herniation ◽  
Stress Responses ◽  
Musculoskeletal Diseases ◽  
Herbal Medicines ◽  
Intervertebral Disc Herniation ◽  
Therapeutic Effects ◽  
Inflammatory Stress ◽  
Cellular Processes ◽  
Vegf Signaling

Eucommiae cortex (EC) and Achyranthis radix (AR) are herbal medicines widely used in combination for the treatment of intervertebral disc herniation (IDH). The mechanisms of action of the herbal combination have not been understood from integrative and comprehensive points of view. By adopting network pharmacological methodology, we aimed to investigate the pharmacological properties of the EC-AR combination as a therapeutic agent for IDH at a systematic molecular level. Using the pharmacokinetic information for the chemical ingredients of the EC-AR combination obtained from the comprehensive herbal drug-associated databases, we determined its 31 bioactive ingredients and 68 IDH-related therapeutic targets. By analyzing their enrichment for biological functions, we observed that the targets of the EC-AR combination were associated with the regulation of angiogenesis; cytokine and chemokine activity; oxidative and inflammatory stress responses; extracellular matrix organization; immune response; and cellular processes such as proliferation, apoptosis, autophagy, differentiation, migration, and activation. Pathway enrichment investigation revealed that the EC-AR combination may target IDH-pathology-associated signaling pathways, such as those of cellular senescence and chemokine, neurotrophin, TNF, MAPK, toll-like receptor, and VEGF signaling, to exhibit its therapeutic effects. Collectively, these data provide mechanistic insights into the pharmacological activity of herbal medicines for the treatment of musculoskeletal diseases such as IDH.

Langzeitevaluation postoperativer Schmerzen nach thorakolumbaler Hemilaminektomie

2020 ◽  
Vol 48 (05) ◽  
pp. 377-377
Keyword(s):  
Postoperative Pain ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Neuropathischer Schmerz ◽  
Intervertebral Disc Herniation ◽  
Pain Evaluation ◽  
Ca 50

Zidan N, Medland J, Olby NJ. Long-term postoperative pain evaluation in dogs with thoracolumbar intervertebral disc herniation after hemilaminectomy. J Vet Intern Med 2020. doi: 10.1111/jvim.15800. Beim Menschen ist chronischer neuropathischer Schmerz eine häufige Komplikation nach Rückenmarksinsulten, ca. 50–80 % der Patienten entwickeln eine derartige Dolenz. Für den Hund liegen diesbezüglich keine Studiendaten vor, vor allem aufgrund der herausfordernden Evaluierung insbesondere von neuropathischen Schmerzzuständen. Diese Studie prüfte die Verlässlichkeit einer Messung von spinalen mechanisch ausgelösten sensorischen Schwellenwerten (mechanical sensory threshholds, MSTs) und verglich die MSTs gesunder Hunde mit denen von Hunden nach operativer Hemilaminektomie aufgrund einer thorakolumbaren intervertebralen Diskherniation (IVDH).

Comparative analysis of neurological recovery and adverse effects in chondrodystrophic dogs with thoracolumbar intervertebral disc herniation treated with methylprednisolone versus non-steroidal anti-inflammatory drugs

2021 ◽  
Author(s):  
William McCartney ◽  
Ciprian Andrei Ober ◽  
Maria Benito
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Sodium Succinate ◽  
Neurological Recovery ◽  
Intervertebral Disc Herniation ◽  
Cord Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Thoracolumbar intervertebral disc herniation is a common neurologic disease presented to the small-animal practitioner. The use of methylprednisolone sodium succinate (MPSS) as an adjunct to surgical decompression in cases of acute spinal cord injury following intervertebral disc extrusion is controversial. A prospective study was undertaken to compare the preoperative use of MPSS and non-steroidal anti-inflammatory drugs (NSAIDs) in 40 chondrodystrophic dogs presenting with similar signs and undergoing spinal decompressive surgery. Twenty dogs received MPSS and 20 had NSAIDs administered preoperatively. Dogs were administered with either MPSS intravenously 20 minutes before surgery (30 mg/kg) or NSAID (meloxicam 0.2mg/kg or carprofen 4 mg/kg) subcutaneously 20 minutes before surgery. Dogs were evaluated by neurologic examination of gait 24 hours postoperatively, at time of discharge and then at 8 weeks. The neurological recovery were similar in both groups, but the frequency of side effects such as vomiting (MPSS group: 90% versus NSAIDs group: 55%), and anorexia within the first three days (present in all 20 dogs pretreated with MPSS) was significantly different, with complications being more prevalent in the MPSS group. Side effects were significantly more evident with MPSS treatment group –including vomiting and anorexia during the first 3 days after surgery– than with NSAID treatment group, with a neurological recovery similar in both groups.

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