Expression of IL-25, IL-33, and Thymic Stromal Lymphopoietin in Nasal Polyp Gland Duct Epithelium in Patients With Chronic Rhinosinusitis

2019 ◽  
Vol 33 (4) ◽  
pp. 378-387 ◽  
Author(s):  
Yoshiyuki Nagata ◽  
Shuichiro Maruoka ◽  
Yasuhiro Gon ◽  
Kenji Mizumura ◽  
Hiroyuki Kishi ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Mucosa ◽  
Nasal Polyp ◽  
Cytokine Expression ◽  
Thymic Stromal Lymphopoietin ◽  
Eosinophilic Infiltration ◽  
Duct Cells ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Gland Duct

Background Nasal polyps accompany eosinophilic chronic rhinosinusitis (ECRS). Cytokines, including interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) expressed in nasal mucosa have been implicated in polyp pathogenesis. We investigated the role of nasal polyp epithelium cytokine expression in eosinophilic infiltration in ECRS. Methods Tissues were collected from 39 patients undergoing nasal surgery. Cases were divided into 3 groups: control (CTR), non-ECRS (nECRS), and ECRS and were evaluated for IL-25, IL-33, and TSLP expression. Results Abundant eosinophilia was observed underneath the nasal mucosa and around the nasal ducts in polyps in ECRS and correlated positively with IL-33 protein expression. Conclusion Cytokine expression in nasal duct cells and eosinophilic infiltration around duct cells similar to those in the nasal mucosa occurred in the nasal epithelium of polyps, suggesting its role in inducing eosinophilic inflammation.

Role of local allergic inflammation and Staphylococcus aureus enterotoxins in Chinese patients with chronic rhinosinusitis with nasal polyps

2017 ◽  
Vol 131 (8) ◽  
pp. 707-713 ◽  
Author(s):  
K-J Cheng ◽  
Y-Y Xu ◽  
M-L Zhou ◽  
S-H Zhou ◽  
S-Q Wang
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Immunoglobulin E ◽  
Allergic Inflammation ◽  
Staphylococcal Enterotoxin ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Local Allergy

AbstractObjective:To investigate the role of local allergic inflammation and Staphylococcus aureus enterotoxins in chronic rhinosinusitis with nasal polyps.Methods:This study included 36 patients with chronic rhinosinusitis with nasal polyps and 18 controls. Total immunoglobulin E, eosinophil cationic protein, staphylococcal enterotoxin types A and B specific immunoglobulin E, staphylococcal enterotoxin types A and B, and myeloperoxidase levels were determined.Results:Four patients with chronic rhinosinusitis with nasal polyps had a local allergy. All chronic rhinosinusitis with nasal polyps patients tested negative for staphylococcal enterotoxin types A and B specific immunoglobulin E. The chronic rhinosinusitis with nasal polyps group had significantly elevated staphylococcal enterotoxin types A and B levels in the supernatant. Fourteen patients belonged to the eosinophilic chronic rhinosinusitis with nasal polyps group and the others were characterised as having non-eosinophilic chronic rhinosinusitis with nasal polyps.Conclusion:Local allergy may play a role in chronic rhinosinusitis with nasal polyps, independent of staphylococcal enterotoxin superantigens. Staphylococcal enterotoxins may be important in the pathogenesis of chronic rhinosinusitis with nasal polyps; however, their roles as superantigens were not confirmed in this study. In Chinese subjects, chronic rhinosinusitis with nasal polyps usually manifests as a neutrophilic inflammation.

scholarly journals The role of bacteriotherapy in the restoration of the nasal mucosa in patients with chronic rhinosinusitis

2021 ◽  
pp. 62-67
Author(s):  
Alexander N. Naumenko ◽  
Ahmad Abdelrazzaq Moh’dabdel razzaq ◽  
Margaryta R. Amirkhanova
Keyword(s):  
Topical Corticosteroid ◽  
Chronic Rhinosinusitis ◽  
Nasal Spray ◽  
Nasal Mucosa ◽  
Mometasone Furoate ◽  
Streptococcus Salivarius ◽  
Saline Irrigation ◽  
Significant Difference ◽  
Snot 22

Topicality: Chronic rhinosinusitis is an polyetiological disease with shch basic complaints as nasal obstruction, nasal discharge, headache or facial pain and reduction of smell. The SNOT-22 questionnaire is widely used to detail patient complaints in various fields. Chronic rhinosinusitis is most often divided into chronic rhinosinusitis with polyps and without nasal polyps. Given the large number of phenotypes and endotypes of the disease, it is important to study further the mechanisms of pathogenesis and selec- tion of individualized treatment. Aim: to determine the role of topical application of Streptococcus salivarius 24SMBc and Streptococcus orals 89a in the form of nasal spray in improving the condition of the nasal mucosa in chronic rhinosinusitis and reducing the recurrence rate. Materials and methods: The study was conducted at the Department of Otolaryngology of National Medical University on the basis of KNP "Oleksandrivs’ka Clinical Hospital of Kyiv". It was attended by 82 patients (38 women and 44 men) aged 18 to 60 years, who were randomly divided into two groups. The 1st group (main, 43 patients) received treatment: irrigation therapy with isotonic saline, topical corticosteroid mometasone furoate in combination with a nasal spray, which contains autochthonous saprophytes (AC) – Streptococcus salivarius 89SMBc and Streptococcus orals 89a nasal mucus. The 2nd group (control, 39 patients) received nasal saline irrigation therapy, topical corticosteroid mometasone furoate in combination with topical antibiotic framicetin sulfate. Assessment was performed according to the VAS scale, SNOT-22 questionnaire (before treatment, on the 10th day of treatment and one month after the end of therapy) and determining the frequency of relapses in patients of both groups. Results: According to the obtained results, the indicators of patients of both groups before treatment and on the 10th day had no statistically significant difference (p>0.05). However a month later patients in the main group had better results (p<0.05) on the scale of VAS and the SNOT-22 questionnaire. So, topical use of Streptococcus salivarius 24SMBc and Streptococcus orals 89a as a nasal spray is effective and can be recommended for the treatment of patients with chronic rhinosinusitis in the acute stage.

Keratinocyte Growth Factor and its Receptor Messenger RNA Expression in Nasal Mucosa and Nasal Polyps

1998 ◽  
Vol 107 (10) ◽  
pp. 885-890 ◽  
Author(s):  
Toshio Ishibashi ◽  
Tadashi Tanaka ◽  
Shin-Ichi Ishimoto ◽  
Ken-Ichi Nibu ◽  
Kimitaka Kaga
Keyword(s):  
Growth Factor ◽  
Mrna Expression ◽  
Nasal Mucosa ◽  
Nasal Polyp ◽  
Messenger Rna ◽  
Nasal Polyps ◽  
Keratinocyte Growth Factor ◽  
Basic Fgf ◽  
Inflammatory Conditions

To examine the potential biologic role of fibroblast growth factors (FGFs) in nasal polyps and nasal mucosa during chronic inflammatory conditions, we investigated messenger RNA (mRNA) expression of three members of the FGF family — Acidic FGF, basic FGF, and keratinocyte growth factor (KGF) — in nasal polyp tissues, as well as in hyperplastic nasal mucosa. Using the sensitive method reverse transcription-polymerase chain reaction (RT-PCR), we demonstrated that of the examined FGFs, KGF had the most abundant mRNA expression in nasal polyps and nasal mucosa. We also found that significantly higher levels of KGF mRNA were expressed in nasal polyps than in nasal mucosa, whereas mRNA expression of acidic FGF and basic FGF was relatively low in these tissues. In addition, we showed that KGF receptor mRNA was present in most of the nasal mucosa; however, none or little was expressed in nasal polyps. These results suggest that KGF might play an important role in nasal epithelial proliferation and that excessive synthesis of KGF in nasal polyp stroma may contribute to hypertrophy of the nasal mucosa in patients with chronic sinusitis associated with nasal polyposis.

scholarly journals Fungal extracts detected in eosinophilic chronic rhinosinusitis induced cytokines from the nasal polyp cells

2014 ◽  
Vol 124 (9) ◽  
Author(s):  
Mikio Hirotsu ◽  
Akihito Shiozawa ◽  
Noritsugu Ono ◽  
Masato Miwa ◽  
Ken Kikuchi ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyp ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Fungal Extracts
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