Brain Metastases from Ewing's Sarcoma

Ewing's sarcoma accounts for approximately 30% of primary malignant bone tumors, mainly in children and young adults. At the time of diagnosis many patients already have metastatic spread of the disease, most often to the lungs and skeletal system. Intracerebral metastases are rare — the reported incidence is up to 4.3%. We describe two cases of metastatic deposits within the brain tissue. Signal intensity of the lesions was similar to that of meningioma on all sequences. Strong homogenous enhancement after gadolinium administration was also similar to meningioma.

Download Full-text

Malignant Bone Tumors in Children: Ewing's Sarcoma

Hematology/Oncology Clinics of North America ◽

10.1016/s0889-8588(18)30646-4 ◽

1987 ◽

Vol 1 (4) ◽

pp. 667-673 ◽

Cited By ~ 8

Author(s):

Paul A. Meyers

Keyword(s):

Bone Tumors ◽

Ewing’S Sarcoma ◽

Ewing's Sarcoma ◽

Malignant Bone Tumors

Download Full-text

The role of imaging of malignant bone tumors in children and young adults

Current Problems in Cancer ◽

10.1016/j.currproblcancer.2013.07.005 ◽

2013 ◽

Vol 37 (4) ◽

pp. 181-191 ◽

Cited By ~ 1

Author(s):

Kuntal A. Rana ◽

John Meyer ◽

Saman Ibrahim ◽

Michael Ralls ◽

Paul M. Kent

Keyword(s):

Young Adults ◽

Bone Tumors ◽

Malignant Bone Tumors ◽

Children And Young Adults

Download Full-text

Intradural Spinal Metastasis in Ewing's Sarcoma: Case Report and Review of the Literature

Neurosurgery ◽

10.1097/00006123-198412000-00019 ◽

1984 ◽

Vol 15 (6) ◽

pp. 873-877 ◽

Cited By ~ 1

Author(s):

Steven L. Wald ◽

Thomas A. Roland

Keyword(s):

Nervous System ◽

Ewing’S Sarcoma ◽

Ewing's Sarcoma ◽

Spinal Metastasis ◽

Disease Recurrence ◽

Skeletal System ◽

The Central Nervous System ◽

Previously Treated ◽

Intradural Metastasis ◽

Children And Young Adults

Abstract Ewing's sarcoma is a rare primary osseous neoplasm of children and young adults. The use of radiotherapy and adjuvant chemotherapy has favorably influenced the outcome of patients and dramatically reduced the rate of local disease recurrence. However, distant metastasis, usually to the lung and skeletal system, continues to be a frequent preterminal event. Metastasis to the central nervous system is infrequent unless related to adjacent bone involvement. We report a case of intraneural, intradural metastasis in a young man with a previously treated Ewing's sarcoma of the ilium. Metastasis to this part of the nervous system has not been previously reported.

Download Full-text

Ewing's Sarcoma and Second Malignancies

Sarcoma ◽

10.1155/2011/736841 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Joshua D. Schiffman ◽

Jennifer Wright

Keyword(s):

Young Adults ◽

Ewing’S Sarcoma ◽

Ewing's Sarcoma ◽

High Dose ◽

Rare Tumor ◽

Childhood Cancers ◽

Genetic Contribution ◽

Second Malignancies ◽

Children And Young Adults ◽

Dose Radiation

Ewing's sarcoma (ES) is a rare tumor that is most common in children and young adults. Late effects of ES therapy include second cancers, a tragic outcome for survivors of such a young age. This paper will explore the frequencies and types of malignancies that occur after ES. Additionally, it will review how second malignancies have changed with the shift in treatment from high-dose radiation to chemotherapy regimens including alkylators and epipodophyllotoxins. The risk of additional cancers in ES survivors will also be compared to survivors of other childhood cancers. Finally, the possible genetic contribution to ES and second malignancies will be discussed.

Download Full-text

Malignant bone tumors in Pediatrics. Five year experience in a pediatric referral center

Revista de la Facultad de Medicina ◽

10.15446/revfacmed.v64n3.50475 ◽

2016 ◽

Vol 64 (3) ◽

pp. 403

Author(s):

Gisela Barros ◽

Angela Maria Trujillo ◽

Lina Jaramillo ◽

Francy Helena Ortiz ◽

Agustin Dario Contreras

Keyword(s):

Neoadjuvant Chemotherapy ◽

Bone Tumors ◽

Ewing’S Sarcoma ◽

Surgical Intervention ◽

Ewing's Sarcoma ◽

Survival Rates ◽

Pediatric Hospital ◽

Malignant Bone Tumors ◽

Primary Bone Tumors ◽

Primary Bone

Background: Osteosarcoma (OS) and Ewing’s Sarcoma (ES) are the two most common malignant bone tumors in children. A retrospective review of the records of children diagnosed in a pediatric hospital over a five year period (2008-2013) was performed.Objective: To present the experiences acquired during the treatment of these types of tumors and to compare the results obtained with those reported in the literature.Methodology: The database of the Oncology and Pathology Service of Fundación Hospital de la Misericordia (HOMI) was reviewed to identify patients with primary bone tumors referred for histopathology analysis.Results: 22 patients were diagnosed with OS, with a mean age of 11.9 years. 96% of cases were located in the lower extremities. All patients received neoadjuvant chemotherapy and 86% underwent surgical treatment; 13% survived. 15 patients were diagnosed with ES, with a mean age of 12.4 years. 67% of cases were located in flat bones, 53% of patients had metastasis when diagnosed, and all received neoadjuvant chemotherapy. 40% of patients received surgical intervention and 20% received radiotherapy. Survival at the completion of the reseearch was 33%.Conclusions: Cure and survival rates are lower than those reported in the literature despite efforts to improve treatments.Keywords: Osteosarcoma; Ewing’s Sarcoma; Disease Progression; Recurrence; Neoplasm Metastasis (MeSH).

Download Full-text