scholarly journals A case of chronic cough due to sarcoidosis

2021 ◽  
pp. 201010582110190
Author(s):  
Qin Jian Low ◽  
Mohd Nadzri Bin Misni ◽  
Seng Wee Cheo ◽  
Khai Lip Ng ◽  
Noorul Afidza Muhammad
Keyword(s):  
Computed Tomography ◽  
Chronic Cough ◽  
Pulmonary Sarcoidosis ◽  
Granulomatous Disease ◽  
Unknown Aetiology ◽  
Caseous Necrosis ◽  
Night Sweats ◽  
Histopathological Lesion ◽  
Treatment Of Sarcoidosis ◽  
Steroid Sparing

Sarcoidosis is a multisystemic, chronic granulomatous disease of unknown aetiology that often affects the lungs. Diagnosis and treatment of sarcoidosis can be strenuous. Patients may be asymptomatic or experience cough, dyspnoea, fatigue, unintentional weight loss or night sweats. Computed tomography is valuable in the diagnosis of sarcoidosis. The typical histopathological lesion of sarcoidosis is granuloma without caseous necrosis in the involved organs. As tuberculosis is endemic in our region, clinicians should not forget this great mimicker. The cornerstone of treatment of sarcoidosis is corticosteroids but newer agents such as steroid-sparing agents and biological agents are available. We report a case of pulmonary sarcoidosis presenting with chronic cough.

FDG-PET/CT Assessment of Pulmonary Sarcoidosis: A Guide for Internists

2018 ◽  
Vol 15 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Marco Tana ◽  
Silvio di Carlo ◽  
Marcello Romano ◽  
Massimo Alessandri ◽  
Cosima Schiavone ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Fdg Pet ◽  
Correct Diagnosis ◽  
Pulmonary Sarcoidosis ◽  
High Resolution Computed Tomography ◽  
Inflammatory Conditions ◽  
Positron Emission ◽  
Pet Ct ◽  
Noncaseating Granulomas ◽  
Fdg Pet Ct

Background:18F-fluorodeoxyglucose positron emission tomography integrated with computed tomography (18-F-FDG-PET/CT) is getting wide consensus in the diagnosis and staging of neoplastic disorders and represents a useful tool in the assessment of various inflammatory conditions. </P><P> Discussion: Sarcoidosis is an uncommon disease characterized by the systemic formation of noncaseating granulomas. Lungs are the sites most often affected, and investigation with high resolution computed tomography and biopsy is essential to achieve a correct diagnosis. 18-F-FDGPET/ CT is effective in the assessment of pulmonary sarcoidosis by demonstrating pulmonary and extrathoracic involvement and findings correlate well with pulmonary function in patients affected.Conclusion:This review would illustrate the usefulness and limits of 18-F-FDG-PET/CT in the assessment of pulmonary sarcoidosis.

Gastrointestinal Computed Tomography Findings in Chronic Granulomatous Disease with Subgroup Clinicopathologic Analysis

2021 ◽  
Author(s):  
Sumona Bhattacharya ◽  
Yilun Koethe ◽  
Alexander Ling ◽  
Natasha Kamal ◽  
Sajneet Khangura ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Chronic Granulomatous Disease ◽  
Granulomatous Disease

scholarly journals Tofacitinib as a Steroid-Sparing Therapy in Pulmonary Sarcoidosis, an Open-Label Prospective Proof-of-Concept Study

Lung ◽  
2021 ◽  
Author(s):  
Marcia A. Friedman ◽  
Brian Le ◽  
Janelle Stevens ◽  
Julianna Desmarais ◽  
Daniel Seifer ◽  
...  
Keyword(s):  
Pulmonary Sarcoidosis ◽  
Proof Of Concept ◽  
Open Label ◽  
Concept Study ◽  
Steroid Sparing

scholarly journals Should computed tomography and bronchoscopy be routine examinations for chronic cough?

2020 ◽  
Vol 12 (9) ◽  
pp. 5238-5242
Author(s):  
Li Yu ◽  
Xianghuai Xu ◽  
Shanshan Niu
Keyword(s):  
Computed Tomography ◽  
Chronic Cough

Steroid-Sparing Effect Of Mycophenolate Mofetil In Pulmonary Sarcoidosis

2010 ◽  
Author(s):  
Preetam Jolepalem ◽  
Nevins W. Todd ◽  
Edward J. Britt ◽  
Michael Terrin ◽  
Carla Peterman ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Pulmonary Sarcoidosis ◽  
Sparing Effect ◽  
Steroid Sparing

scholarly journals Sarcoidosis Presenting as Massive Splenic Infarction

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Ishita Patel ◽  
Mediola Ismajli ◽  
Alan Steuer
Keyword(s):  
Granulomatous Inflammation ◽  
Splenic Infarction ◽  
Granulomatous Disease ◽  
Unknown Aetiology ◽  
Rare Occurrence ◽  
Massive Splenomegaly

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology. Granulomatous inflammation involving the spleen is common and associated with splenomegaly. However, massive splenomegaly is a rare occurrence. Infrequently massive splenomegaly can result in splenic infarction. Massive splenic infarction in sarcoidosis has, to our knowledge, not been previously reported. We present a case of a woman presenting with massive splenic infarction and sarcoidosis confirmed by granulomatous inflammation of the liver.

scholarly journals EFFICIENCY AND SAFETY OF LEFLUNOMIDE TREATMENT IN PATIENTS WITH PULMONARY SARCOIDOSIS

2018 ◽  
Vol 2 ◽  
pp. 38-43
Author(s):  
Volodymyr Gavrysiuk ◽  
Ievgeniia Merenkova ◽  
Galyna Gumeniuk
Keyword(s):  
Diabetes Mellitus ◽  
Computed Tomography ◽  
Side Effects ◽  
Pulmonary Sarcoidosis ◽  
Thoracic Cavity ◽  
Body Plethysmography ◽  
First Line ◽  
Combined Use ◽  
Poor Tolerability

Patients who have contraindications to the prescription of GCs (glucocorticosteroids), or have developed serious side effects during treatment with GCs, as well as patients with resistance to GCs therapy, are prescribed immunosuppressants. The aim of the research - to study the efficacy of leflunomide monotherapy in patients with pulmonary sarcoidosis with contraindications to prescription or serious side effects of glucocorticosteroids. Fourteen patients with sarcoidosis of the respiratory system of stage II were examined – 12 women and 2 men aged 30 to 69 years. In 10 patients there were contraindications to the appointment of GCs (diabetes mellitus – 5, hypertension – 3, obesity – 1, exacerbation of gastric ulcer – 1), which caused the appointment of immunosuppressive therapy as a starting. In 4 cases, serious side effects of SCs were noted, requiring the drug to be abolished (osteoporosis – 3, steroid diabetes – 1). Leflunomide was administered at a dose of 20 mg per day, daily for 3 months. The evaluation of efficacy was carried out using computed tomography of the thoracic cavity organs, body plethysmography, spirometry and determination of the diffusivity of the lungs. Monotherapy with leflunomide in patients with contraindications to prescription or serious side effects of GCs was successful in 7 out of 13 patients, in 2 patients there was a stabilization of the process, in 4 patients with leflunomide therapy progression of the disease was noted and in 1 case the treatment was discontinued due to serious side effects of preparation. The results obtained make it possible to recommend the use of leflunomide as monotherapy in patients with pulmonary sarcoidosis with contraindications to the prescription and/or poor tolerability of GCs and methotrexate. It is necessary to continue studying the possibilities of combined use of leflunomide with other drugs of the first line.

scholarly journals Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study

2020 ◽  
Vol 98 (10) ◽  
pp. 33-40
Author(s):  
A. A. Vizel ◽  
D. A. Culver ◽  
I. Yu. Vizel ◽  
G. R. Shakirova ◽  
E. A. Bakunina
Keyword(s):  
Computed Tomography ◽  
Vitamin E ◽  
High Frequency ◽  
Control Point ◽  
Pulmonary Sarcoidosis ◽  
Alpha Tocopherol ◽  
Newly Diagnosed ◽  
X Ray ◽  
Löfgren Syndrome

The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment. Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair principle (gender, age, initial X-ray stage, Löfgren syndrome, and follow-up duration). The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). The database was maintained and processed using SPSS-18, Windows 10. A clear advantage of vitamin E administration was revealed when comparing the data of computed tomography, which resulted in improvement in 87.5%, and the disease progressed in 2.5%, while in the group receiving no treatment – 60 and 12.5%, respectively. The OR of improvement in computed tomography with alpha-tocopherol versus the group receiving no treatment made 4.67 (95% CI, 1.51-14.46).Conclusion. The use of vitamin E in mild forms of thoracic sarcoidosis gives a better result compared to the group receiving no treatment.

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