Ovomucoid Specific Immunoglobulin E as a Predictor of Tolerance to Cooked Egg

Background Ovomucoid is the dominant allergen in hen's egg. Although several studies evaluated the utility of ovomucoid specific immunoglobulin E (sIgE) levels in predicting baked (e.g., muffin or cupcake) or raw egg food challenge outcomes, studies that evaluated ovomucoid sIgE as a predictor of cooked egg (e.g., scrambled or hard boiled) challenge outcomes are limited. Objective To determine the relation of ovomucoid sIgE levels with cooked egg food challenge outcomes. Methods A retrospective review of 44 children who underwent cooked egg food challenge and who had the ovomucoid sIgE level measured. Results Thirty-six of 44 children (81.8%) passed cooked egg challenge. The ovomucoid sIgE level predicted cooked egg challenge outcome (passed median, <0.35 kU/L [range, <0.35–0.64 kU/L]; failed median, 0.40 kU/L [range, <0.35–3.13 kU/L]; p = 0.004). Ovomucoid sIgE levels correlated with egg white (EW) sIgE levels (Spearman correlation coefficient, 0.588; p = 0.001). Receiver operating characteristic curve analysis of ovomucoid and EW sIgE demonstrated areas under the curve of 0.711 and 0.766, respectively. No significant difference was observed among those immunologic parameters in their abilities to predict cooked egg challenge outcome (p = 0.559). Conclusion The ovomucoid sIgE level may be helpful in predicting cooked egg challenge outcomes. However, our study did not support a role for ovomucoid sIgE replacing EW sIgE testing in evaluating egg allergy.

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Legume and sesame oral food challenge outcomes

Journal of Food Allergy ◽

10.2500/jfa.2021.3.210009 ◽

2021 ◽

Vol 3 (2) ◽

pp. 42-49 ◽

Cited By ~ 1

Author(s):

Jacob J. Pozin ◽

Ashley L. Devonshire ◽

Kevin Tom ◽

Melanie Makhija ◽

Anne Marie Singh

Keyword(s):

Regression Models ◽

Operating Characteristic ◽

Immunoglobulin E ◽

Gastrointestinal Symptoms ◽

Food Challenge ◽

Logistic Regression Models ◽

Receiver Operating Characteristic Curves ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Food Challenges

Background: Legume and sesame are emerging food allergens. The utility of specific immunoglobulin E (sIgE) testing to predict clinical reactivity to these allergens is not well described. Objective: To describe clinical outcomes and sIgE in sesame and legume oral food challenges (OFC). Methods: We performed a retrospective review of 74 legume and sesame OFCs between 2007 and 2017 at the Ann and Robert H. Lurie Children’s Hospital of Chicago. Clinical data, OFC outcome, and sIgE to legume and sesame were collected. Receiver operating characteristic curves and logistic regression models that predicted OFC outcome were generated. Results: Twenty-eight patients (median age, 6.15 years) passed legume OFC (84.9%), and 25 patients (median age, 5.91 years) passed sesame OFC (61.0%). The median sIgE to legume was 1.41 kUA/L and, to sesame, was 2.34 kUA/L. In patients with failed legume OFC, 60.0% had cutaneous symptoms, 20.0% had gastrointestinal symptoms, and 20.0% had anaphylaxis. Of these reactions, 80.0% were controlled with antihistamine alone and 20.0% required epinephrine. In patients for whom sesame OFC failed, 50.0% had cutaneous symptoms, 12.5% had gastrointestinal symptoms, and 37.50% had anaphylaxis. Of these reactions, 6.3% required epinephrine, 31.3% were controlled with diphenhydramine alone, and 63.50% required additional epinephrine or prednisone. Conclusion: Most OFCs to legumes were passed and reactions to failed legume OFCs were more likely to be nonsevere. Sesame OFC that failed was almost twice as likely compared with legume OFC that failed, and reactions to sesame OFC that failed were often more severe. Sesame sIgE did not correlate with OFC outcome.

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High Dust Mite specific Immunoglobulin E (sIgE): a Promising Indicator of Allergic Rhinitis to Asthma

10.21203/rs.3.rs-41257/v1 ◽

2020 ◽

Author(s):

Rui Tang ◽

Xiaohong Lyu ◽

Yuelun Zhang ◽

Shi Chen ◽

Hong Li

Keyword(s):

Allergic Rhinitis ◽

House Dust ◽

House Dust Mite ◽

Immunoglobulin E ◽

House Dust Mites ◽

Kaplan Meier ◽

Sige Level ◽

Specific Immunoglobulin E ◽

Dust Mite ◽

Specific Immunoglobulin

Abstract Background: House dust mites are the most prevalent allergens in patients with asthma and/or rhinitis in China. Cross-sectional data in 2009 have shown that allergic rhinitis often preceded or occurred at the same time as asthma in patients which was used to investigate the association of serum specific immunoglobulin E (sIgE) levels to house dust mite with the onset of asthma in patients with allergic rhinitis. Methods: 321 patients with allergic rhinitis were face-to-face interviewed and underwent sIgE tests to house dust mite. The temporal sequence of allergic rhinitis and asthma was documented. Univariate analysis, multinomial logistic regression, and Kaplan-Meier survival analysis were performed. Results: Of the 321 participants, 213 (66.4%) had asthma, which occurred after or simultaneously with rhinitis, and 108 (33.6%) suffered from allergic rhinitis only. After controlling basic parameters, factors correlated to sIgE, and essential factors considered by clinical allergists, the risk of developing asthma always increased with the levels of sIgE to house dust mite in all four models (p < 0.01). In Kaplan–Meier analysis, in the first ten years with allergy rhinitis, a high sIgE level represented a high probability of the coexistence of allergic rhinitis and asthma (p < 0.01). For house dust mite sIgE level 5-6, 5 years Rhinitis-Asthma Conversion Rate (RACR) had reached almost 70%. Conclusion: High-level house dust mite sIgE can exist as an indicator of rhinitis to asthma. It provides a theoretical basis for early intervention in patients with high sIgE levels in order to prevent asthma. This assessment and intervention should be performed at the early stage of rhinitis.

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Result-related factors, safety, and reliability of egg-specific immunoglobulin E in the oral food challenge with lightly heated whole egg -A retrospective study of 227 cases-

Nihon Shoni Arerugi Gakkaishi The Japanese Journal of Pediatric Allergy and Clinical Immunology ◽

10.3388/jspaci.35.220 ◽

2021 ◽

Vol 35 (3) ◽

pp. 220-227

Author(s):

Masaaki Doi ◽

Yasutaka Matsubara ◽

Nayu Iwakoshi ◽

Kumiko Takagi ◽

Aya Sasaki ◽

...

Keyword(s):

Retrospective Study ◽

Immunoglobulin E ◽

Food Challenge ◽

Oral Food Challenge ◽

Related Factors ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Safety And Reliability ◽

Whole Egg

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Skin Prick Tests and Patch Tests in Children with Food Allergies.

10.46940/sjnp.02.1006 ◽

2020 ◽

pp. 1-4

Keyword(s):

Immunoglobulin E ◽

Skin Prick Testing ◽

Food Challenge ◽

Diagnostic Methods ◽

Food Allergies ◽

Sufficient Evidence ◽

Patch Tests ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Skin Prick Tests

Abstract Diagnosing food allergies can be challenging for patients and health professionals. Standard diagnostic methods include skin prick testing, food-specific immunoglobulin E (IgE) and oral food challenge. There is no scientifically sufficient evidence for routine use of patch testing for food allergy evaluation in children.

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Aeroallergen sensitization profile in medically resistant chronic rhinosinusitis

SAGE Open Medicine ◽

10.1177/2050312120933809 ◽

2020 ◽

Vol 8 ◽

pp. 205031212093380

Author(s):

Haitham Odat ◽

Maulla Alali ◽

Mohannad Al-Qudah

Keyword(s):

Chronic Rhinosinusitis ◽

Nasal Polyps ◽

Immunoglobulin E ◽

Academic Center ◽

Significant Difference ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Inhalant Allergens ◽

Blood Eosinophils

Objectives: The aim of this study is to report the aeroallergen sensitization profile in medically resistant chronic rhinosinusitis with or without nasal polyps and its relationship to asthma. Methods: Retrospective charts review of 402 chronic rhinosinusitis patients who failed to respond to medical treatment and scheduled for surgery at a tertiary academic center was performed. One hundred and fifty-five patients had chronic rhinosinusitis with nasal polyps and 247 patients had chronic rhinosinusitis without nasal polyps, furthermore; the two phenotypes were subdivided according to the presence or absence of asthma. Allergen-specific immunoglobulin E to 24 inhalant allergens was measured to all patients by the enzyme allergo-sorbent test. Results: The average age was 35 years ( SD ± 13) with 236 males and 166 females. Two hundred and fifty-three patients (63%) were tested positive for at least one allergen with no significant difference between patients with or without polyp (in chronic rhinosinusitis with nasal polyps, 103 patients (66%) were positive compared with 150 patients (61%) in chronic rhinosinusitis without nasal polyps). There were no significant differences in the prevalence, type, and number of positive allergens between the two phenotypes. The prevalence of asthma was found to be 19% in patients with chronic rhinosinusitis without nasal polyps versus 46% in those with chronic rhinosinusitis with nasal polyps ( p = 0.001), and the prevalence of high eosinophils was 27%, and 47% in both phenotypes, respectively ( p = 0.0001). Conclusions: The prevalence of inhalational allergy in medically resistant chronic rhinosinusitis is high, however, this profile does not differ based on the presence of polyp. Patients with chronic rhinosinusitis with nasal polyps had a higher prevalence of asthma and blood eosinophils as compared with chronic rhinosinusitis without nasal polyps. Our results showed a little role of inhalant allergens in nasal polyps or asthma comorbidity in refractory sinusitis patients.

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Increasing specific immunoglobulin E levels correlate with the risk of anaphylaxis during an oral food challenge

Pediatric Allergy and Immunology ◽

10.1111/pai.12896 ◽

2018 ◽

Vol 29 (4) ◽

pp. 417-424 ◽

Cited By ~ 20

Author(s):

Noriyuki Yanagida ◽

Sakura Sato ◽

Kyohei Takahashi ◽

Ken-ichi Nagakura ◽

Tomoyuki Asaumi ◽

...

Keyword(s):

Immunoglobulin E ◽

Food Challenge ◽

Oral Food Challenge ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin

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Responsiveness of Nasal Provocation Testing—But Not Skin Test and Specific Immunoglobulin E Blood Level—Correlates With Severity of Allergic Rhinitis in Dermatophagoides Species-Sensitized Patients

American Journal of Rhinology and Allergy ◽

10.1177/1945892418779435 ◽

2018 ◽

Vol 32 (4) ◽

pp. 236-243 ◽

Cited By ~ 1

Author(s):

Wang Wanjun ◽

Hu Qiurong ◽

Xie Yanqing ◽

Xian Mo ◽

Wei Nili ◽

...

Keyword(s):

Allergic Rhinitis ◽

Immunoglobulin E ◽

Life Questionnaire ◽

Nasal Provocation ◽

Nasal Symptoms ◽

Sige Level ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Provocation Testing ◽

Nasal Provocation Testing

Background The results of skin and blood allergen testing are not consistently relevant to clinical manifestations in allergic patients. Objective The aim of the study was to investigate the relationship between severity of allergic rhinitis and different allergen diagnostic tests in Dermatophagoides species-sensitized patients. Methods Study subjects included 65 rhinitis patients—50 with Dermatophagoides pteronyssinus (DP) sensitization (DP+) and 15 without DP sensitization (DP−), and 15 DP+ and 37 DP− healthy controls (HCs) confirmed by allergen skin prick (SPT) and blood specific immunoglobulin E (sIgE) tests. The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was tested. All subjects underwent DP nasal provocation test (DP-NPT). Visual analogue scoring (VAS) of nasal symptoms and nasal airway resistance (NAR) were measured before and after NPT. Correlations between the 3 allergen tests and score of RQLQ were performed. Results All rhinitis subjects had significantly higher VAS and NAR after DP-NPT than HCs ( P < .01). All DP+ rhinitis, 40% of DP− rhinitis subjects, 13.3% of DP+ HCs and 0% of DP− HCs had positive DP-NPT. Dose of positive DP-NPT positively correlated with SPT diameter and sIgE level in all tested subjects ( P < .001). Score of RQLQ positively correlated with dose of DP-NPT ( P < .001), but not with SPT diameter and sIgE level in rhinitis patients. Conclusion Although DP nasal provocation, skin prick wheal size and blood sIgE level correlate with each other, only nasal provocation testing is associated with severity of nasal symptoms. It is suggested that NPT should be performed to verify a clinically relevant allergy.

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Optimal cutoff values of allergen-specific immunoglobulin E to house dust mites and animal dander based on skin-prick test results: Analysis in 16,209 patients with allergic rhinitis

American Journal of Rhinology and Allergy ◽

10.2500/ajra.2017.31.4483 ◽

2017 ◽

Author(s):

S. D. Hong ◽

G. Ryu ◽

M. Y. Seo ◽

J. I. Jeong ◽

H. Y. Kim ◽

...

Keyword(s):

Allergic Rhinitis ◽

Immunoglobulin E ◽

House Dust Mites ◽

Test Results ◽

Dust Mites ◽

Optimal Cutoff ◽

Prick Test ◽

Specific Immunoglobulin E ◽

Specific Immunoglobulin ◽

Animal Dander

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Allergic diseases attributable to atopy in a population sample of Asian children

Scientific Reports ◽

10.1038/s41598-021-95579-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Chao-Yi Wu ◽

Hsin-Yi Huang ◽

Wen-Chi Pan ◽

Sui-Ling Liao ◽

Man-Chin Hua ◽

...

Keyword(s):

Immunoglobulin E ◽

Population Attributable Risk ◽

Population Sample ◽

International Study ◽

Allergic Diseases ◽

Population Based ◽

School Age Children ◽

Specific Immunoglobulin E ◽

Asian Children ◽

Specific Immunoglobulin

AbstractThe proportion of allergic diseases attributable to atopy remains a subject of controversy. This study aimed to estimate the population risk of physician-diagnosed asthma, rhinitis and eczema attributed to atopy among a population sample of Asian school-age children. Asian children aged 5–18 years (n = 1321) in the Prediction of Allergies in Taiwanese CHildren (PATCH) study were tested for serum allergen-specific immunoglobulin E. Physician-diagnosed asthma, rhinitis and eczema were assessed by a modified International Study of Asthma and Allergies in Childhood questionnaire. Atopy was defined as the presence of serum allergen-specific immunoglobulin E. In this population-based study, 50.4% of the subjects with asthma, 46.3% with rhinitis, and 46.7% with eczema were attributable to atopy. The population attributable risk (PAR) of atopy for three allergic diseases was higher in adolescents (asthma, 54.4%; rhinitis, 59.6%; eczema, 49.5%) than younger children aged less than 10 years (asthma, 46.9%; rhinitis, 39.5%; eczema, 41.9%). Among the seven allergen categories, sensitization to mites had the highest PARs for all three allergic diseases (51.3 to 64.1%), followed by sensitization to foods (asthma, 7.1%; rhinitis, 10.4%; eczema 27.7%). In conclusion, approximately half (46.3 to 50.4%) of Asian children in Taiwan with allergic diseases are attributable to atopy.

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