scholarly journals Cervical superficial myofibroblastoma: Case report and review of the literature

2017 ◽  
Vol 5 ◽  
pp. 2050313X1772693
Author(s):  
Mohamed Abdelaziz ◽  
Noura Eziba ◽  
Suash Sharma ◽  
Daniel Kleven ◽  
Ayman Al-Hendy
Keyword(s):  
Genital Tract ◽  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Female Genital Tract ◽  
Uterine Fibroids ◽  
Review Of The Literature ◽  
Cervical Mass ◽  
Submucosal Mass ◽  
Mass Lesions ◽  
Female Genital

Superficial myofibroblastoma of the lower female genital tract is a rare benign, recently recognized neoplasm that mostly affects the vulvovaginal area. Our report discusses a case of cervical superficial myofibroblastoma of the lower female genital tract in a 45-year-old patient who is presented with menometrorrhagia. On examination, she had multiple uterine fibroids and a circumscribed submucosal mass lesion involving the anterior lip of cervix. At hysterectomy, histopathological examination of the cervical mass revealed a relatively hypocellular tumor consisted of bland spindled and stellate cells. An immunohistochemistry evaluation revealed reactivity for CD34, desmin, and smooth muscle actin. This neoplasm should be included in the differential diagnosis of cervical mass lesions. This tumor also needs to be differentiated from other mesenchymal lesions of lower female genital tract.

A Rare Case of Cavernous Angiomatosis of the Uterus

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S79-S79
Author(s):  
V Prakash ◽  
C E Middleton ◽  
V Shenoy
Keyword(s):  
Genital Tract ◽  
Histopathological Examination ◽  
English Literature ◽  
Female Genital Tract ◽  
Uterine Fibroids ◽  
Abnormal Uterine Bleeding ◽  
Accurate Diagnosis ◽  
Vascular Tumors ◽  
Unexpected Finding ◽  
Female Genital

Abstract Introduction/Objective Angiomatosis is a rare, non-neoplastic vascular malformation characterized by the proliferation of blood vessels which involve skin, soft tissue, and bone. Angiomatosis of the female genital tract is extremely rare with very few cases described in the English literature. Methods/Case Report We present a case of an unexpected finding of angiomatosis of the uterus and cervix in a 34- year-old nulliparous female with a history of abnormal uterine bleeding and dysmenorrhea of one year duration. Imaging studies showed an anteverted uterus measuring 9 cm × 6 cm × 5 cm with thickened irregular endometrium, blood clots within the endometrial cavity, and subserosal uterine fibroids. A subsequent endometrial curettage showed benign superficial endometrium. Hysterectomy was performed and histopathological examination revealed diffuse haphazardly arranged large vascular channels within the uterine wall and cervical stroma. A diagnosis of cavernous angiomatosis of the uterus and cervix was made. Results (if a Case Study enter NA) NA Conclusion Angiomatosis of the female genital tract is a rare vascular proliferation that tends to grow at a slow rate and cause heavy menstrual bleeding in otherwise healthy patients. Differential diagnoses of angiomatosis include other vascular tumors such as hemangiomas, lymphangioma, arteriovenous malformation and papillary endothelial hyperplasia. Clinical examination and investigations like hysteroscopy, endometrial curettage and ultrasonography may not help in accurate diagnosis. Definitive diagnosis relies heavily on histopathological examination. Treatment of symptomatic angiomatosis is purely surgical and in our case, was curative. Following treatment, recurrences can occur and appropriate surveillance is recommended. Malignant transformation have not been reported. It is important to be aware of this rare entity to make an accurate diagnosis.

scholarly journals Spectrum of histopathological lesions in the fallopian tubes

2013 ◽  
Vol 3 (5) ◽  
pp. 356-360 ◽  
Author(s):  
S Gon ◽  
A Basu ◽  
B Majumdar ◽  
TK Das ◽  
M Sengupta ◽  
...  
Keyword(s):  
Genital Tract ◽  
Histopathological Examination ◽  
Female Genital Tract ◽  
Secondary Malignancies ◽  
Fallopian Tubes ◽  
Serial Sections ◽  
Pathology Laboratory ◽  
Surgical Specimen ◽  
Neoplastic Lesions ◽  
Female Genital

Background: Fallopian tubes are common surgical specimen in the pathology laboratory; still there is a lack of data to describe the frequency of various histological fi ndings. The aim and objectives of this study was to describe the various histopathological fi ndings of fallopian tubes. Materials and Methods: Two thousand fi ve hundred and seventy fi ve cases where fallopian tubes were removed either separately or along with other female genital tract organs were studied retrospectively and their histopathological fi ndings documented. Results: Ectopic pregnancy comprised maximum number of cases closely followed by salpingitis. Primary neoplastic lesions were rare as compared to secondary malignancies. Serial sections of fallopian tube and sections from representative areas are essential for a pathologist so that the diagnosis of these pathological entities is not missed. Conclusion: Though the fallopian tubes remain unremarkable in majority of the surgical pathological specimens, it must be subjected for histopathological examination to demonstrate the pathological lesions. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 356-360 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7858

Solitary Fibrous Tumor of the Female Genital Tract A Case Report and Review of the Literature

2007 ◽  
Vol 26 (3) ◽  
pp. 259-264 ◽  
Author(s):  
Olaf James Biedrzycki ◽  
Naveena Singh ◽  
Hani Habeeb ◽  
Neville Wathen ◽  
Asma Faruqi
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Review Of The Literature ◽  
Fibrous Tumor ◽  
Female Genital

scholarly journals Xanthogranulomatous Endometritis: A Challenging Imitator of Endometrial Carcinoma

2007 ◽  
Vol 2007 ◽  
pp. 1-3 ◽  
Author(s):  
A. Işın Doğan-Ekici ◽  
Alp Usubütün ◽  
Türkan Küçükali ◽  
Ali Ayhan
Keyword(s):  
Endometrial Carcinoma ◽  
Genital Tract ◽  
Plasma Cells ◽  
Histopathological Examination ◽  
Female Genital Tract ◽  
Giant Cells ◽  
Polymorphonuclear Leucocytes ◽  
Xanthogranulomatous Inflammation ◽  
Post Menopausal ◽  
Female Genital

Xanthogranulomatous inflammation is a distinguished histopathological entity affecting several organs, predominantly the kidney and gallbladder. So far, only a small number of cases of xanthogranulomatous inflammation occurring in female genital tract have been described, most frequently affecting the endometrium and histologically characterized by replacement of endometrium by xanthogranulomatous inflammation composed of abundant foamy histiocytes, siderophages, giant cells, fibrosis, calcification and accompanying polymorphonuclear leucocytes, plasma cells and lymphocytes of polyclonal origin. We present a case of a 69-year-old female complained of post menopausal bleeding and weight loss. Clinical preliminary diagnoses were endometrial carcinoma or hyperplasia and ultrasound was supposed to be endometrial malignancy, hyperplasia or pyometra by radiologist. Histopathological examination of uterus revealed xanthogranulomatous endometritis. Since xanthogranulomatous endometritis may mimic endometrial malignancy clinically and pathologically as a result of the replacement of the endometrium and occasionally invasion of the myometrium by friable yellowish tissue composed of histiocytes, knowledge of this unusual inflammatory disease is needed for both clinicians and pathologists.

scholarly journals Hydatid cyst of broad ligament: a rare case report

2020 ◽  
Vol 7 (4) ◽  
pp. 1298
Author(s):  
Ajay Gujar ◽  
Jayant Pednekar ◽  
Nida Khan ◽  
Anurag Tiwary ◽  
Rohith Pillai ◽  
...  
Keyword(s):  
Hydatid Cyst ◽  
Genital Tract ◽  
Histopathological Examination ◽  
Broad Ligament ◽  
Female Genital Tract ◽  
Surgical Excision ◽  
Cystic Mass ◽  
Rare Case Report ◽  
Peculiar Case ◽  
Female Genital

Hydatid cyst is a parasitic disease caused by tapeworm Echinococcus. It affects the liver and lung most commonly, but may rarely affect fallopian tube, broad ligament and other structures. One such peculiar case is where a 17 years old female presented with a rapidly growing cystic mass in lower abdomen, clinically suspicious of ovarian mass or mesentric cyst. Investigations failed to identify the nature. On laparotomy, excision of the mass was done. Suprisingly histopathological examination identified the lesion as hydatid cyst arising from the broad ligament. Patient responded well to surgical excision followed by albendazole administration. Female genital tract hydatidosis is a rare entity and in most cases the involvement is secondary. Primary hydatid disease of female genital tract is even very rarer and generates considerable diagnostic difficulty.

Myogenic Markers in the Evaluation of Embryonal Botryoid Rhabdomyosarcoma of the Female Genital Tract

2005 ◽  
Vol 8 (3) ◽  
pp. 355-361 ◽  
Author(s):  
Wolfram F. J. Riedlinger ◽  
Harry P. W. Kozakewich ◽  
Sara O. Vargas
Keyword(s):  
Smooth Muscle ◽  
Genital Tract ◽  
Smooth Muscle Actin ◽  
Female Genital Tract ◽  
Embryonal Rhabdomyosarcoma ◽  
Nuclear Staining ◽  
Muscle Actin ◽  
Anatomic Site ◽  
Immunohistochemical Markers ◽  
Female Genital

Rhabdomyosarcoma presents special diagnostic problems when it involves the uterine cervix in young children because tumor cells may lack marked atypia and may blend with the normal, immature, condensed, cellular stroma, rendering diagnosis difficult. Myogenic makers are a valuable ancillary technique for establishing a diagnosis of rhabdomyosarcoma. However, desmin positivity has been reported in cervical stromal cells, which can confound diagnosis. To determine whether immunohistochemical markers of skeletal muscle differentiation are helpful in the diagnosis of uterine botryoid rhabdomyosarcoma, we compared the immunohistochemical staining pattern of cervical rhabdomyosarcoma from 3 patients with that of normal uteri from age-matched autopsy controls by using antibodies for desmin, smooth muscle actin, muscle-specific actin, myoD1, myogenin, and WT-1. All tumors demonstrated at least focal immunopositivity for desmin, muscle-specific actin, smooth muscle actin, myoD1, and WT-1, and 1 tumor was also positive for myogenin. Autopsy controls showed only scattered subepithelial stromal immunoreactivity for desmin, muscle-specific actin, smooth muscle actin, and WT-1 and showed cytoplasmic, but not nuclear, immunopositivity for myoD1 and myogenin. Myometrium was diffusely positive for desmin and muscle-specific actin. We conclude that desmin, muscle-specific actin, smooth muscle actin, and WT1 are not specific for discriminating embryonal rhabdomyosarcoma from normal subepithelial cells in the female genital tract of children, although the number of immunopositive cells is consistently larger in rhabdomyosarcoma. Nuclear staining for myoD1 and myogenin appears not to occur in normal tissue, but it may be absent or sparse in embryonal rhabdomyosarcoma. Our findings indicate that, in this anatomic site, the diagnosis of rhabdomyosarcoma and in particular determination of tumor margins remain very reliant on histomorphology.

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