scholarly journals Metastatic small cell carcinoma of the lung with prominent spindle cell morphology and hemangiopericytoma-like vascular pattern: A sarcoma mimicker

2020 ◽  
Vol 8 ◽  
pp. 2050313X2098117
Author(s):  
Esra Nsour ◽  
Ali Al Khader ◽  
Bushra Al-Tarawneh
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Spindle Cell ◽  
Small Cell ◽  
Nerve Sheath Tumor ◽  
Vascular Pattern ◽  
Nerve Sheath ◽  
History Of ◽  
Wall Mass ◽  
Aggressive Clinical Behavior

Small cell carcinoma is a malignant neuroendocrine tumor with aggressive clinical behavior. Histologically, the tumor is characterized by the proliferation of small, round, blue cells. Here, we present the case of a 50-year-old man with a 1-month history of enlarging chest wall mass. Microscopic examination of the lesion revealed a highly cellular neoplasm composed of closely packed, atypical spindle cells with scant cytoplasm, inconspicuous nucleoli, and brisk mitotic activity. The hemangiopericytoma-like vascular pattern was prominent. Areas showing a fibrosarcoma-like fascicular pattern were also observed. The tumor was immunohistochemically positive for TTF1, synaptophysin, and chromogranin, confirming small cell carcinoma. Further investigations revealed a lung origin and widespread metastases. The tumor in this case closely mimicked synovial sarcoma or malignant peripheral nerve sheath tumor. Small cell carcinoma demonstrates a hemangiopericytoma-like pattern that can mimic sarcoma histologically. This is a serious pitfall that can significantly affect the speed of diagnosis and management.

Hypercalcaemia due to ovarian small cell carcinoma of the hypercalcaemic type

2021 ◽  
Vol 14 (7) ◽  
pp. e243571
Author(s):  
Annalisa Montebello ◽  
Mark Gruppetta
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Incidental Finding ◽  
Lower Abdominal Pain ◽  
Ovarian Tumour ◽  
Small Cell ◽  
Pelvic Radiotherapy ◽  
Wide Range ◽  
History Of ◽  
Parathyroid Hormone Related Peptide

A 37-year-old woman presented with a few days’ history of lower abdominal pain and an incidental finding of hypercalcaemia. A thorough workup ensued, and the cause was found to be an exceptionally rare ovarian tumour—ovarian small cell carcinoma of the hypercalcaemic type. Acute treatment of hypercalcaemia consisted of aggressive intravenous fluids and bisphosphonates. She underwent surgery to remove the tumour and is currently receiving systemic platinum/etoposide chemotherapy combination to be followed by pelvic radiotherapy. This case highlights the wide range of differential diagnosis for hypercalcaemia and the importance of a stepwise and thorough approach during investigations. We discuss the pathophysiology of malignancy-related hypercalcaemia, focusing especially on parathyroid hormone-related peptide-associated hypercalcaemia.

scholarly journals Primary Small Cell Carcinoma of the Hypopharynx: A Case Report of a Rare Tumor

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ali Bayram ◽  
Ebru Akay ◽  
Sema S. Göksu ◽  
İbrahim Özcan
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Systemic Chemotherapy ◽  
Metastatic Potential ◽  
Pyriform Sinus ◽  
Small Cell ◽  
Rare Tumor ◽  
History Of ◽  
The Right

Introduction. Primary hypopharynx involvement of small cell carcinoma is very rare and very few cases have been reported in the literature. Here, we report a case of primary small cell carcinoma of the hypopharynx in a male patient.Case Report. A 50-year-old man presented with a 6-month history of sore throat and swellings in the right side of the neck. Direct laryngoscopy and biopsy revealed small cell carcinoma of the hypopharynx located in the right pyriform sinus.Discussion. Small cell carcinoma of the hypopharynx has no clear treatment modality due to the rarity of the disease. Systemic chemotherapy and radiotherapy should have priority among the therapy regimens because of the high metastatic potential of the tumor.

Rare case of metastatic small cell carcinoma of the nasopharynx to the pancreas

2020 ◽  
Vol 13 (6) ◽  
pp. e235054 ◽  
Author(s):  
Jonathan Teinor ◽  
Lara Groshek ◽  
Jin He
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Primary Tumour ◽  
Treatment Options ◽  
Needle Aspiration ◽  
Concurrent Chemotherapy ◽  
Small Cell ◽  
Tissue Mass ◽  
Positron Emission ◽  
History Of

We present a 49-year-old woman with a history of an unresectable nasopharyngeal small cell carcinoma (SCC) who was treated with concurrent chemotherapy and radiation therapy. On surveillance positron emission tomography scan 14 months after diagnosis, her primary tumour appeared stable, but there was fludeoxyglucose uptake in the pancreas. A CT scan demonstrated a 3.4×2.1 cm ill-defined soft tissue mass at the tail of the pancreas, which was concerning for adenocarcinoma. However, further workup including endoscopic ultrasound and fine needle aspiration confirmed the mass to be a metastasis from her nasopharyngeal SCC. Because there have been no previously reported cases of a metastatic small cell carcinoma to the pancreas, there are no data about prognosis. Thus treatment options were tailored to the patient. Distal pancreatectomy, splenectomy and cholecystectomy were performed. The patient recovered from surgery without complication.

scholarly journals Extrapulmonary small cell carcinoma of the external auditory canal: a case report and review of the literature

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094651
Author(s):  
Jianyan Wang ◽  
Danqing Liu ◽  
Yingdi Meng ◽  
Yingyuan Guo ◽  
Ming Zhao
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
External Auditory Canal ◽  
Small Cell ◽  
Purulent Discharge ◽  
Surgical Removal ◽  
Eyelid Closure ◽  
Reasonable Approach ◽  
History Of ◽  
Extrapulmonary Small Cell Carcinoma

Extrapulmonary small cell carcinoma (EPSCC) affecting the external auditory canal (EAC) is uncommon. We herein report a case involving a 56-year-old man with EPSCC of the EAC who had a 48-year history of recurrent purulent discharge in both ears and a 20-day history of right ear pain and hemorrhage followed by incomplete right eyelid closure and an askew mouth. He underwent surgical removal of middle ear granulation tissue, residual ossicles, and a right EAC mass. Postoperatively, pathomorphological examination combined with immunohistochemical staining supported a diagnosis of small cell carcinoma. Radiation therapy at a dose of 60.06 Gy in 33 daily fractions was completed 1 month after surgery, and synchronous etoposide–cisplatin regimen chemotherapy was performed for two cycles and four sequential cycles. One year postoperatively, magnetic resonance imaging showed no tumor in the ear; however, computed tomography showed multiple liver space-occupying lesions that were considered to indicate liver metastasis. Further chemotherapy was performed, but the patient died 15 months postoperatively. This case indicates that timely and accurate chemoradiotherapy is likely the most reasonable approach to EPSCC of the EAC given the aggressiveness of this tumor.

scholarly journals Gastric Small-Cell Carcinoma Found on Esophagogastroduodenoscopy: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Natassja Frances ◽  
Simon B. Zeichner ◽  
Michael Francavilla ◽  
Mike Cusnir
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Epigastric Pain ◽  
Gastric Wall ◽  
Rare Condition ◽  
Small Cell ◽  
Japanese Male ◽  
History Of ◽  
Lesser Curvature ◽  
Hispanic Male

Introduction. Characterized as an undifferentiated, neuroendocrine tumor arising from totipotent stem cells, small-cell carcinoma (SCC) most commonly arises from the lung. Extrapulmonary small-cell carcinomas (ESCC) are rare and account for only four percent of SCC. Gastric ESCC, more commonly seen in Japanese male patients in their seventh decade of life, accounts for approximately 0.1 percent of ESCC.Case Presentation. A 75-year-old Hispanic male presented with a several week history of worsening epigastric pain with nausea and vomiting. Computer tomography (CT) of the abdomen and pelvis showed a large heterogeneous mass involving the posterior gastric wall with diffuse extension into the gastric cardia. Esophagogastroduodenoscopy (EGD) revealed a large fungating mass in the lesser curvature of the stomach. Biopsy of the mass revealed small-cell carcinoma of the stomach. The patient was diagnosed with extensive/stage 4 disease and started on chemoradiation.Discussion. Our case, of a very rare condition highlights, the importance of recognizing atypical pathologic diagnoses. More research will need to be conducted with GSCC patients in order to better characterize disease pathogenesis, genetic mutations, and optimal disease management. The hope is to identify biomarkers that will identify patients earlier in their disease course when cure is possible.

Ovarian small cell carcinoma of hypercalcaemic-type: History of the disease in a patient who refused treatment

2011 ◽  
Vol 31 (4) ◽  
pp. 354-356
Author(s):  
V. Benito ◽  
D. Martínez ◽  
A. Lubrano ◽  
O. Arencibia ◽  
O. Falcón
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
History Of

scholarly journals Preliminary Presentation of Metastatic Non-Small Cell Carcinoma of the Lung as Atraumatic Avulsion Fracture of the Lesser Trochanter

2020 ◽  
Vol 13 (1) ◽  
pp. 436-441
Author(s):  
Adam Creissen ◽  
Aysha Rajeev ◽  
Kumud Jain ◽  
Paul Banaszkiewicz
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Groin Pain ◽  
Avulsion Fracture ◽  
Small Cell ◽  
Avulsion Fractures ◽  
Lesser Trochanter ◽  
Tumour Biopsy ◽  
History Of ◽  
Lesser Trochanter Avulsion

Traumatic avulsion fractures of the lesser trochanter are usually seen along with fractures of the proximal femur and with young adolescents involved in high-intensity sporting injuries. Atraumatic isolated lesser trochanter avulsion in adults are most commonly associated with malignancy. We describe a case of a female in her sixties who was previously fit and healthy with no systemic illness and no history of trauma presenting with groin pain. The X-ray demonstrated an isolated lesser trochanter avulsion fracture. Further imaging including MRI and a staging CT scan of the neck, chest, abdomen and pelvis revealed a pulmonary tumour. Biopsy later confirmed this as a non-small cell carcinoma of the lung. At the time of publication, she had been started on palliative chemotherapy (afatinib) with encouraging results.

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