Systematic review and meta-analysis: Sodium picosulphate with magnesium citrate as bowel preparation for colonoscopy

Abstract Aims Pre-operative oral antibiotics (OAB) and mechanical bowel preparation (MBP) may reduce rates of post-operative infectious complications following colorectal surgery but their effects on post-operative ileus (POI) are not well-established. We conducted a systematic review and meta-analysis to address this question. Methods Medline and Embase databases were searched to identify randomised controlled trials and cohort studies comparing pre-operative MBP or OAB to control in patients undergoing elective colorectal resection and reporting the rate of POI as an outcome. Risk ratios were pooled using a random-effects model to generate a summary risk ratio and 95% confidence interval. Results Five randomised trials and three cohort studies were included which reported the effect of pre-operative MBP on POI. Some 29056 patients received MBP compared to 13077 who did not. The rates of POI were 10.0% vs 12.0% respectively. Meta-analysis gave a risk ratio of 0.85 (0.80-0.91, p < 0.0001) for the development of POI with MBP versus control. Four randomised trials and four cohort studies were included which reported the effect of pre-operative OAB on POI. Some 9.5% of 19,903 patients receiving OAB developed POI compared to 11.8% of 23,884 control patients. The pooled risk ratio for the development of POI with OAB compared to control was 0.86 (0.81-0.91, p < 0.0001). However, when limiting analyses to randomised trials alone, neither MBP (RR 1.13, 0.67-1.90) nor OAB 1.01, 0.75-1.35) had a significant effect on the rate of POI. Conclusions Pre-operative MBP or OAB may reduce POI following colorectal resection but this has not been confirmed in randomised trials.

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Sa1075 Safety of Sodium Picosulphate-Based Bowel Preparation: A Meta-Analysis.

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2016.03.298 ◽

2016 ◽

Vol 83 (5) ◽

pp. AB226

Author(s):

Alessandro Repici ◽

Sandro Sferrazza ◽

Stefanos Bonovas ◽

Milena Di Leo ◽

Loretta Amato ◽

...

Keyword(s):

Bowel Preparation ◽

Meta Analysis ◽

Sodium Picosulphate

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Single versus split dose polyethylene glycol for bowel preparation in children undergoing colonoscopy: a systematic review and meta-analysis

Annals of Palliative Medicine ◽

10.21037/apm-20-582 ◽

2020 ◽

Vol 9 (5) ◽

pp. 3028-3037

Author(s):

Jinjin Cao ◽

Weiying Zhang ◽

Jiajie Hu ◽

Yan Huang ◽

Li Zhao ◽

...

Keyword(s):

Systematic Review ◽

Polyethylene Glycol ◽

Bowel Preparation ◽

Meta Analysis ◽

Split Dose ◽

Single Versus

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Sa1061 Split-Dose Bowel Preparation Does Not Increase Gastric Residual Volume as Compared With Day Prior Preparations: A Systematic Review and Network Meta-Analysis

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2017.03.380 ◽

2017 ◽

Vol 85 (5) ◽

pp. AB174-AB175 ◽

Cited By ~ 1

Author(s):

Danny J. Avalos ◽

Majd Michael ◽

Fernando Castro-Pavia ◽

Daniel Sussman ◽

Jose L. Gonzalez Martinez ◽

...

Keyword(s):

Systematic Review ◽

Bowel Preparation ◽

Meta Analysis ◽

Residual Volume ◽

Gastric Residual Volume ◽

Split Dose

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Effects of walking exercise on bowel preparation in patients undergoing colonoscopy: evidence from systematic review and meta-analysis

Frontiers of Nursing ◽

10.2478/fon-2020-0009 ◽

2020 ◽

Vol 7 (1) ◽

pp. 39-47 ◽

Cited By ~ 1

Author(s):

Yuan-Yuan Zhang ◽

Min Yan ◽

Jing Li ◽

Min-Li Fu ◽

Ling Xie ◽

...

Keyword(s):

Systematic Review ◽

Abdominal Pain ◽

Bowel Preparation ◽

Meta Analysis ◽

Exercise Group ◽

Cochrane Library ◽

Control Group ◽

China National Knowledge Infrastructure ◽

Walking Exercise ◽

The Cochrane Library

AbstractObjectiveThis meta-analysis aimed to evaluate the effects of walking exercise on bowel preparation in patients undergoing colonoscopy.MethodsPubMed, Web of Science, EMBASE, Ovid, The Cochrane Library, Wanfang Data, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, and Chinese BioMedical Database were searched from their inception to January 2019. Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) examining the effects of walking exercise in patients undergoing colonoscopy were considered for inclusion. After screening literature, extracting data and evaluating methodological quality, RevMan 5.3 software was used for meta-analysis.ResultsFive studies (four RCTs and one CCTs) involved 984 participants were included. The results of meta-analysis demonstrated that the walking exercise group showed significantly higher improvements in the rate of adequate bowel preparation than the control group (risk ratio [RR] = 1.28, 95% confidence interval [CI] [1.03–1.58], P < 0.05). In addition, the walking exercise group had lower incidence of vomiting (RR = 0.39, 95% CI [0.23–0.68], P < 0.01) and abdominal pain (RR = 0.51, 95% CI [0.29–0.90], P < 0.05) with lower heterogeneity.ConclusionsThis systematic review and meta-analysis provided specific evidence that walking exercise during bowel preparation can improve the rate of adequate bowel preparation and reduce the incidence of vomiting and abdominal pain in patients undergoing colonoscopy. Since the conclusion of this meta-analysis was drawn based on the limited number of high-quality RCTs, more rigorous RCTs should be conducted in the future.

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STRATEGIES TO IMPROVE HOSPITALIZED PATIENT'S QUALITY OF BOWEL PREPARATION FOR COLONOSCOPY: SYSTEMATIC REVIEW AND META-ANALYSIS

10.1055/s-0038-1637327 ◽

2018 ◽

Author(s):

P Gkolfakis ◽

G Tziatzios ◽

IS Papanikolaou ◽

GD Dimitriadis ◽

K Triantafyllou

Keyword(s):

Systematic Review ◽

Bowel Preparation ◽

Meta Analysis

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Use of smartphone applications to improve quality of bowel preparation for colonoscopy: a systematic review and meta-analysis

Endoscopy International Open ◽

10.1055/a-0796-6423 ◽

2019 ◽

Vol 07 (02) ◽

pp. E216-E224 ◽

Cited By ~ 7

Author(s):

Madhav Desai ◽

Venkat Nutalapati ◽

Ajay Bansal ◽

Daniel Buckles ◽

John Bonino ◽

...

Keyword(s):

Systematic Review ◽

Bowel Preparation ◽

Meta Analysis ◽

Smartphone App ◽

Control Group ◽

Smartphone Apps ◽

Standard Education ◽

Bowel Cleansing ◽

Bowel Prep

Abstract Introduction Smartphone-based applications (apps) have been used to improve the quality of bowel preparation (prep) but the success rates have been variable. We have performed a systematic review and meta-analysis to evaluate the impact of smartphone apps on bowel preparation. Methods Electronic databases (MEDLINE, Embase, CINAHL and Cochrane) were reviewed for eligible studies of smartphone apps versus standard education before colonoscopy. The following outcomes were analyzed: pooled rate of adequacy of bowel prep among both arms and Boston bowel preparation score (BBPS) when reported. Pooled analysis was reported as odds ratio (OR) or mean difference in random effect model with Review Manager 5.3 (P ≤ 0.05 for statistical significance). Results Six studies were eligible with smartphone app (810 patients) vs. standard education (855 patients, control group) for bowel prep. The smartphone app group had a higher proportion of adequate bowel prep compared to the control group: 87.5 % vs 77.5 % (five studies), pooled OR 2.67; 95 %CI 1.00 – 7.13 with P = 0.05. There was substantial heterogeneity in studies with I 2 = 78 %. When analysis was limited to randomized controlled trials (RCTs), smartphone app users had a numerically higher rate of bowel cleansing: 87.1 % vs 76.9 %; however, pooled OR was not statistically significant (OR 2.66, 95 %CI 0.92 – 7.69, P = 0.07). When studies using BBPS were evaluated (n = 3), smartphone app users had higher mean scores (better bowel prep) with a mean difference of 0.9 (95 %CI 0.5 – 1.3), which was statistically significant (P < 0.01). Conclusion The smartphone app is a novel educational tool that can assist in achieving adequate and better bowel cleansing before colonoscopy.

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