scholarly journals Hepatosplenic T-cell lymphoma with hepatocytotropism in a cat

2021 ◽  
Vol 7 (1) ◽  
pp. 205511692110059
Author(s):  
Tatsuhito Ii ◽  
James K Chambers ◽  
Kazuhito Segawa ◽  
Kazuyuki Uchida
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Granzyme B ◽  
Lymphoid Cells ◽  
T Cell Lymphoma ◽  
Cytological Examination ◽  
Hepatic Sinusoid ◽  
Case Summary ◽  
Mixed Breed ◽  
Hepatosplenic T Cell Lymphoma

Case summary A 14-year 3-month-old spayed female mixed-breed cat presented with jaundice, anaemia and thrombocytopenia. Haemophagocytic syndrome associated with lymphoma was suspected after cytological examination of the spleen. Despite treatment with prednisolone, L-asparaginase and nimustine, the cat died 176 days after the initial presentation. Necropsy revealed splenomegaly and hepatomegaly, without lymphadenopathy. Histopathologically, neoplastic lymphoid cells infiltrated the hepatic sinusoid and splenic sinus. The neoplastic lymphoid cells showed marked hepatocytotropism and contained erythrocytes, which was also confirmed by electron microscopy. Immunohistochemically, neoplastic lymphoid cells were positive for CD3, TIA1 (GMP-17) and granzyme B, and negative for CD8, CD20, CD56, CD57, CD79a and Iba1. Based on these findings, the cat was diagnosed with hepatosplenic T-cell lymphoma (HS-TCL) with hepatocytotropism. Relevance and novel information This case shows cytotoxic immunophenotype of HS-TCL in a cat, which has not been demonstrated before. Severe hepatocytotropism and haemophagocytosis of the neoplastic cells were likely to be associated with jaundice and anaemia, respectively, and the poor outcome of the present case.

scholarly journals Primary Epitheliotropic T-cell Lymphoma of the Urinary Bladder in a Dog

2000 ◽  
Vol 37 (2) ◽  
pp. 184-186 ◽  
Author(s):  
P. Maiolino ◽  
G. DeVico
Keyword(s):  
T Cell ◽  
Urinary Bladder ◽  
Physical Examination ◽  
Cell Lymphoma ◽  
Postmortem Examination ◽  
Lymphoid Cells ◽  
T Cell Lymphoma ◽  
Intact Female ◽  
Mucosal Epithelium ◽  
Mixed Breed

A 7-year-old, intact female mixed-breed dog was presented for evaluation of hematuria. Physical examination revealed a suprapubic mass. Ultrasonographic examination showed a large lobular mass occupying the urinary bladder. At the owners' request, the dog was euthanatized and a postmortem examination was performed. Necropsy confirmed the presence of a lobular mass of about 5- to 6-cm diameter protruding into the lumen of the bladder. Histologically, the mass was composed of a large number of atypical lymphoid cells in the lamina propria and mucosal epithelium. Immunohistochemically, the neoplastic cells expressed CD3 but not CD79α or keratin and vimentin, supporting a diagnosis of T-cell lymphoma.

scholarly journals Hepatosplenic T-cell lymphoma: Report of two cases

2014 ◽  
Vol 1 (2) ◽  
pp. 54
Author(s):  
Ekarat Rattarittamrong ◽  
Lalita Norrasethada ◽  
Charin Ya-In ◽  
Lertlakana Bhoopat ◽  
Adisak Tantiworawit ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Current Treatment ◽  
Lymphoid Cells ◽  
T Cell Lymphoma ◽  
Treatment Modalities ◽  
High Dose ◽  
Rare Type ◽  
Chop Regimen ◽  
Hepatosplenic T Cell Lymphoma

Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of lymphoma. Presenting with hepatosplenomegaly, fever, cytopenia without significant lymphadenopathy, most patients are young men with poor outcomes. Here is the report of two cases of HSTCL from Maharaj Nakorn Chiang-Mai Hospital, Thailand. Both patients were middle-aged men presented with prolonged fever, hepatosplenomegaly and cytopenia. Abnormal lymphoid cells, not demonstrated by flow cytometry, were microscopically revealed in the patients’ bone marrow. The diagnosis of HSTCL was based on the histopathologic section obtained from splenectomy and liver biopsy. Both patients received cyclophosphamide, doxorubicin, vincristine, prednisolone (CHOP) regimen initially while one of them was salvaged with etoposide, methylprednisolone, cytarabine, cisplatin (ESHAP) and methotrexate, high-dose cytarabine, methylprednisolone (cycle B of hyperCVAD) regimen. They responded poorly to chemotherapy and succumbed to severe sepsis. The presented cases confirmed that HSTCL is very difficult to diagnose and current treatment modalities appear to be ineffective

Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome: analysis of 25 patients

2016 ◽  
Vol 50 ◽  
pp. 109-117 ◽  
Author(s):  
Mariko Yabe ◽  
L. Jeffrey Medeiros ◽  
Guilin Tang ◽  
Sa A. Wang ◽  
Keyur P. Patel ◽  
...  
Keyword(s):  
T Cell ◽  
Myelodysplastic Syndrome ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Hepatosplenic T Cell Lymphoma ◽  
Syndrome Analysis

Hepatosplenic T-cell lymphoma and TNF-α inhibitors

2009 ◽  
Vol 2 (6) ◽  
pp. 611-614 ◽  
Author(s):  
Jenny Vu Pozadzides ◽  
Barbara Pro
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Tnf Α ◽  
Hepatosplenic T Cell Lymphoma

Hepatosplenic T cell lymphoma in inflammatory bowel disease

Gut ◽  
2008 ◽  
Vol 57 (12) ◽  
pp. 1639-1641 ◽  
Author(s):  
M. Shale ◽  
E. Kanfer ◽  
R. Panaccione ◽  
S. Ghosh
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cell ◽  
Bowel Disease ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Hepatosplenic T Cell Lymphoma ◽  
Inflammatory Bowel

scholarly journals Hepatosplenic T-cell lymphoma: A case series

2015 ◽  
Vol 8 (2) ◽  
pp. 78-84 ◽  
Author(s):  
Philippa Ashmore ◽  
Moosa Patel ◽  
Jenifer Vaughan ◽  
Tracey Wiggill ◽  
Pascale Willem ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Case Series ◽  
T Cell Lymphoma ◽  
Hepatosplenic T Cell Lymphoma

scholarly journals Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic gamma delta T-cell origin

Blood ◽  
1996 ◽  
Vol 88 (11) ◽  
pp. 4265-4274 ◽  
Author(s):  
CB Cooke ◽  
L Krenacs ◽  
M Stetler-Stevenson ◽  
TC Greiner ◽  
M Raffeld ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Killer Cell ◽  
Clinical Manifestations ◽  
Lymphoid Cells ◽  
T Cell Lymphoma ◽  
Survival Duration ◽  
Adult Males ◽  
Gamma Delta ◽  
Gamma Delta T Cell

We identified eight cases of T-cell lymphoma with evidence of a gamma delta phenotype over a 13-year period. Seven of these cases conformed to a distinct clinicopathologic entity of hepatosplenic gamma delta T- cell lymphoma. Nearly all of these patients were young adult males (five of seven), with a median age at presentation of 20 years. They presented with marked hepatosplenomegaly, without lymphadenopathy or significant peripheral blood lymphocytosis. Thrombocytopenia was seen in all patients, and five of seven were mildly anemic. The clinical course was aggressive, and despite multiagent chemotherapy, the median survival duration was less than 1 year. The morphologic findings were uniform; a monomorphic population of medium-sized lymphoid cells with moderately clumped chromatin and a rim of pale cytoplasm infiltrated the sinusoids of the spleen, liver, and bone marrow. The cells had a characteristic immunophenotype: CD2+, CD3+, CD4-, CD5-, CD7+, CD16+, CD57-, CD25-, T-cell receptor (TCR)delta +, beta F1-. CD8 was positive in four of seven cases tested, and CD56 was positive in five of six. All cases expressed the cytotoxic granule-associated protein, TIA1, but perforin was detected in only one case. All cases with assessable DNA had a TCR gamma gene rearrangement, and lacked Epstein-Barr virus sequences. Isochromosome 7q was identified in two cases with cytogenetic information. The one case of cutaneous gamma delta T-cell lymphoma differed in its clinical manifestations, histologic appearance, and immunophenotype. We conclude that hepatosplenic gamma delta T-cell lymphoma is a distinct clinicopathologic entity derived from cytotoxic gamma delta T cells, and should be distinguished from other lymphomas of T-cell and natural-killer cell (NK)-like T-cell derivation.

Sign in / Sign up

Export Citation Format

Share Document