scholarly journals Management of Unoperated Tetralogy of Fallot in a 59-Year-Old Patient

2020 ◽  
Vol 8 ◽  
pp. 232470962092690
Author(s):  
Robin Boyer ◽  
Hyung Jin Kim ◽  
Rajagopal Krishnan
Keyword(s):  
Right Ventricular ◽  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Ventricular Hypertrophy ◽  
Septal Defect ◽  
Treatment Guidelines ◽  
Outflow Obstruction ◽  
Ventricular Outflow Obstruction ◽  
Cardiology Clinic ◽  
Hispanic Male

Tetralogy of Fallot is the most common cyanotic congenital heart defect consisting of an overriding aorta, right ventricular outflow obstruction, ventricular septal defect, and right ventricular hypertrophy. Without surgical management, approximately only 3% of patients survive past the age of 40 years. Cases of unoperated patients reaching adulthood have been reported; however, few studies describe treatment guidelines for surgical or therapeutic management. In this article, we report the case of a 59-year-old Hispanic male with unoperated tetralogy of Fallot presenting to our cardiology clinic for initial workup and management.

scholarly journals Recurrent cerebral abscess in tetralogy of Fallot

2016 ◽  
Vol 44 (5) ◽  
pp. 206
Author(s):  
Wanty Sahli ◽  
J M Ch Pelupessy
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Ventricular Septal Defect ◽  
Right Ventricular ◽  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Ventricular Hypertrophy ◽  
Septal Defect ◽  
Pulmonary Stenosis ◽  
Cerebral Abscess

Tetralogy of Fallot (TF) classically consistsof the combination of right ventricularoutflow obstruction (pulmonary stenosis),ventricular septal defect (VSD), overridingaorta, and right ventricular hypertrophy. Thedegree of pulmonary stenosis and VSD determine thevariety of clinical manifestations.This type of congenital heart disease accountsfor about 10% of all congenital cardiac deformitiesand is the most common cyanotic lesion after thefirst year of life. Cerebral abscess is a serious com-plication in TF and is usually seen after the age of 2years.

Failure of Cellularization of Ventriculotomy Patch Leading to Right Ventricular Pseudoaneurysm

2019 ◽  
Vol 11 (1) ◽  
pp. 123-126
Author(s):  
Sruti Rao ◽  
Robert D. Stewart ◽  
Gosta Pettersson ◽  
Carmela Tan ◽  
Suzanne Golz ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Ventricular Septal Defect ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Septal Defect ◽  
Tricuspid Atresia ◽  
Outflow Obstruction ◽  
Ventricular Outflow Obstruction ◽  
The Right ◽  
Double Inlet Left Ventricle

Enlargement of the bulboventricular foramen (BVF) in double-inlet left ventricle or the ventricular septal defect (VSD) in tricuspid atresia with transposition of the great arteries is one approach for prevention or treatment of systemic ventricular outflow obstruction. Most often, BVF/VSD restriction is bypassed preemptively or addressed directly at the time of Glenn/Fontan procedures as part of staged univentricular palliation. We describe a patient who underwent enlargement of a restrictive VSD during Fontan completion and subsequently presented with an asymptomatic pseudoaneurysm of the right ventricle at the ventriculotomy site.

scholarly journals Right Ventricular Outflow Obstruction by a Membranous Septal Aneurysm in a Ventricular Septal Defect

2020 ◽  
Vol 36 (3) ◽  
pp. 252-255
Author(s):  
Yuhei Yamashita ◽  
Satoshi Marutani ◽  
Kosuke Nishi ◽  
Kazushi Ueshima ◽  
Nori Takata ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Right Ventricular ◽  
Septal Defect ◽  
Outflow Obstruction ◽  
Ventricular Outflow Obstruction

Membranous septal aneurysm causing severe right ventricular outflow obstruction in an adult with trisomy 18

2021 ◽  
pp. 1-2
Author(s):  
Christopher Herron ◽  
Thomas J Forbes ◽  
Daisuke Kobayashi
Keyword(s):  
Ventricular Septal Defect ◽  
Right Ventricular ◽  
Septal Defect ◽  
Trisomy 18 ◽  
Outflow Obstruction ◽  
Ventricular Outflow Obstruction

Abstract Membranous ventricular septal aneurysm is a known entity but rarely causes severe right ventricular outflow obstruction. We report a 40-year-old female with trisomy 18 who developed severe right ventricular outflow obstruction caused by an enormous membranous septal aneurysm associated with unrepaired inlet ventricular septal defect with perimembranous extension.

Acquired subvalvular right ventricular outflow obstruction in patients with ventricular septal defect

1972 ◽  
Vol 53 (4) ◽  
pp. 446-455 ◽  
Author(s):  
Richard L. Shepherd ◽  
D.Luke Glancy ◽  
Richard B. Jaffe ◽  
Joseph K. Perloff ◽  
Stephen E. Epstein
Keyword(s):  
Ventricular Septal Defect ◽  
Right Ventricular ◽  
Septal Defect ◽  
Outflow Obstruction ◽  
Ventricular Outflow Obstruction

scholarly journals Genetic testing for tetralogy of Fallot

2018 ◽  
Vol 2 (s1) ◽  
pp. 71-73
Author(s):  
Yeltay Rakhmanov ◽  
Paolo Enrico Maltese ◽  
Carla Marinelli ◽  
Tommaso Beccari ◽  
Munis Dundar ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Right Ventricular ◽  
Tetralogy Of Fallot ◽  
Ventricular Hypertrophy ◽  
Septal Defect ◽  
Autosomal Dominant ◽  
Heart Defects ◽  
Pulmonary Stenosis ◽  
Congenital Cardiac Defects ◽  
Gene Test

Abstract Tetralogy of Fallot (ToF) combines congenital cardiac defects including ventricular septal defect, pulmonary stenosis, an overriding aorta and right ventricular hypertrophy. Clinical manifestation of this defect depends on the direction and volume of shunting of blood through the ventricular septal defect and the associated right ventricular and pulmonary artery pressures. ToF accounts for 3-5% of congenital heart defects or 0.28 cases every 1000 live births. ToF has autosomal dominant inheritance. This Utility Gene Test was developed on the basis of an analysis of the literature and existing diagnostic protocols. It is useful for confirming diagnosis, as well as for differential diagnosis, couple risk assessment and access to clinical trials.

scholarly journals Left ventricular hypertrophy with right ventricular outflow obstruction.

Heart ◽  
1972 ◽  
Vol 34 (7) ◽  
pp. 752-754 ◽  
Author(s):  
T Dellocchio ◽  
A Dolara ◽  
L Salvatore ◽  
R Vergassola
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Outflow Obstruction ◽  
Ventricular Outflow Obstruction

scholarly journals Screening of NKX2.5 gene in Moroccan Tetralogy of Fallot (TOF) patients: worldwide mutation rate comparisons show a significant association between R25C variant and TOF phenotype

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ihssane EL Bouchikhi ◽  
Khadija Belhassan ◽  
Fatima Zohra Moufid ◽  
Laila Bouguenouch ◽  
Imane Samri ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Tetralogy Of Fallot ◽  
Mutation Rate ◽  
Septal Defect ◽  
Perinatal Period ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
The World ◽  
Ventricular Outflow Obstruction

Abstract Background Tetralogy of Fallot is the most prevalent cyanotic congenital heart disease, occurring in 1/3 600 live births. This disorder comprises ventricular septal defect, right ventricular outflow obstruction, over-riding aorta, and right ventricular hypertrophy. The present study aims to reveal the spectrum of Nk2 homeobox 5 (NKX2-5) variants identified in a Moroccan non-syndromic tetralogy of Fallot cohort and to compare mutation rate with different studies from all over the world. Thirty-one patients with non-syndromic tetralogy of Fallot were recruited in this cross-sectional study. DNAs were extracted, and coding regions of NKX2.5 were PCR-amplified and sequenced. The obtained sequences were analyzed using different bioinformatics tools. Statistical comparisons were carried out using the R software. Results R25C mutation was found in two patients, in association with the E21E variant. The latter variant was frequently observed in the population and seems to have a potential altering effect on the splicing process. The NKX2.5 mutation rate in our tetralogy of Fallot population is around 6.4%, and no significant difference was noticed in comparison with previous studies. At the same time, a comparison of R25C mutation rate between atrial septal defect and tetralogy of Fallot worldwide populations shows a particular association of R25C mutation with tetralogy of Fallot phenotype. Conclusions This study reveals a consistency between our NKX2.5 mutation rate and those of different tetralogy of Fallot populations around the world. Our findings suggest a possible combined effect of R25C mutation and E21E variant on the carriers and emphasize particularly the significant association of R25C mutation with tetralogy of Fallot, which highlights the importance of an anticipative screening for TOF phenotype among the carriers’ offspring at the perinatal period.

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