scholarly journals Optical coherence tomography and optical coherence tomography angiography in glaucoma: diagnosis, progression, and correlation with functional tests

2020 ◽  
Vol 12 ◽  
pp. 251584141989982
Author(s):  
Giacinto Triolo ◽  
Alessandro Rabiolo
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Optical Coherence Tomography Angiography ◽  
Present Review ◽  
Clinical Use ◽  
Optical Coherence ◽  
Functional Tests ◽  
Glaucoma Diagnosis

The present review will summarize the most updated findings with regards to optical coherence tomography and optical coherence tomography angiography in glaucoma, highlighting their clinical use for detection and monitoring of the disease, and their correlation to functional tests (such as visual field) widely employed in the asset of modern glaucoma clinics.

Rapid response to systemic steroid in macular alexandrite laser exposure: Multimodal imaging

2020 ◽  
pp. 112067212092434
Author(s):  
Melike Balikoglu-Yilmaz ◽  
Mahmut Kaya ◽  
Murat Erbezci ◽  
Suleyman Kaynak
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Visual Field ◽  
Visual Field Defect ◽  
Optical Coherence Tomography Angiography ◽  
Hair Removal ◽  
Optical Coherence ◽  
Alexandrite Laser ◽  
Laser Hair Removal ◽  
Field Defect

Purpose To report the management of accidental macular photocoagulation during a 750-nm Alexandrite laser hair removal procedure. Methods Single case report with images. Results A 23-year-old girl presented with an immediate visual field defect in her right eye after direct inadvertent exposure to a single discharge from a 750-nm Alexandrite laser used for laser hair removal. Baseline Snellen visual acuity was 20/20 in the involved right eye but the patient reported a subjective visual field defect. She was treated with oral methylprednisolone that was started at a dose of 1 mg/kg/day and then gradually reduced. Six months after the initial exposure, the final visual acuity was 20/20 and there was a significant improvement in the macular lesion. However, the subjective visual field defect continued. She underwent multimodal retinal imaging with optical coherence tomography, fundus fluorescence angiography, and optical coherence tomography angiography in addition to a visual field test and microperimety. Conclusion The present case documents a gradual visual and anatomical improvement following macular photic damage after accidental occupational exposure to a 750-nm Alexandrite laser. The treatment should be arranged according to the localization of the laser damage. Optical coherence tomography angiography also has the potential to help noninvasively detect choriocapillaris damage.

scholarly journals Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma

Ophthalmology ◽  
2016 ◽  
Vol 123 (12) ◽  
pp. 2498-2508 ◽  
Author(s):  
Adeleh Yarmohammadi ◽  
Linda M. Zangwill ◽  
Alberto Diniz-Filho ◽  
Min Hee Suh ◽  
Siamak Yousefi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Optical Coherence Tomography Angiography ◽  
Visual Field Loss ◽  
Vessel Density ◽  
Optical Coherence

Effect of algorithms and covariates in glaucoma diagnosis with optical coherence tomography angiography

2021 ◽  
pp. bjophthalmol-2020-318677
Author(s):  
Qi Sheng You ◽  
Ou Tan ◽  
Shaohua Pi ◽  
Liang Liu ◽  
Ping Wei ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Accuracy ◽  
Nerve Fibre ◽  
Optical Coherence Tomography Angiography ◽  
Signal Strength ◽  
Vessel Density ◽  
Optical Coherence ◽  
Glaucoma Diagnosis ◽  
Nerve Fibre Layer ◽  
Normal Controls

PurposeTo assess the effects of algorithms and covariates in glaucoma diagnosis with optical coherence tomography angiography (OCTA).MethodsIn this prospective cross-sectional study, one eye each of 36 normal controls and 64 patients with glaucoma underwent 4.5 mm disc-centred and 6 mm macula-centred OCTA scans. The peripapillary nerve fibre layer plexus capillary density (NFLP-CD) and macular superficial vascular complex vessel density (SVC-VD) were measured using both a commercial algorithm (AngioAnalytics) and a custom algorithm (Center for Ophthalmic Optics & Lasers Angiography Reading Toolkit (COOL-ART)). The nerve fibre layer and ganglion cell complex thicknesses were measured on structural OCT.ResultsThe overall peripapillary NFLP-CD and macular SVC-VD measured with the two algorithms were highly correlated but poorly agreed. Among the normal controls, the perfusion measurements made by both algorithms were significantly correlated with age. AngioAnalytics measurements were also correlated with signal strength index, while COOL-ART measurements were not. These covariates were adjusted. The diagnostic accuracy, measured as the area under the receiver operating characteristic curve for glaucoma detection, was not significantly different between algorithms, between structural and perfusion parameters and between the peripapillary and macular regions (All p>0.05). The macular SVC-VD in the 6 mm square had a significantly higher diagnostic accuracy than that of the central 3 mm square area (p=0.005).ConclusionsAngioAnalytics and COOL-ART vessel density measurements are not interchangeable but potentially interconvertible. Age and signal strength are significant covariates that need to be considered. Both algorithms and both peripapillary and macular perfusion parameters have similarly good diagnostic accuracy comparable to structural OCT. A larger macular analytic area provides higher diagnostic accuracy.

Relationship between vessel density and visual field sensitivity in glaucomatous eyes with high myopia

2018 ◽  
Vol 103 (5) ◽  
pp. 585-591 ◽  
Author(s):  
Joong Won Shin ◽  
Junki Kwon ◽  
Jiyun Lee ◽  
Michael S Kook
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
High Myopia ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Nerve Fibre Layer ◽  
Vessel Density ◽  
Optical Coherence ◽  
Regional Correlation ◽  
Field Sensitivity ◽  
Nerve Fibre Layer

AimsTo investigate the global and regional relationships between peripapillary vessel density (pVD) and visual field mean sensitivity (VFMS) in glaucomatous eyes with and without high myopia in comparison with those between peripapillary retinal nerve fibre layer thickness (pRNFLT) and VFMS.MethodsA total of 130 eyes from 130 patients with glaucoma consisting of those with and without high myopia were included in a consecutive manner. High myopia was defined as a spherical equivalent <−6.0 dioptres or axial length >26.5 mm. The pVD and pRNFLT were evaluated using optical coherence tomography angiography (OCT-A) and spectral-domain optical coherence tomography. VFMS was assessed using a linear unlogged 1/L scale. The vasculature–function or structure–function relationships were analysed by comparing the pVD or pRNFLT to the corresponding VFMS, according to Garway-Heath map regionalisation.ResultsThe global pVD-VFMS association was significantly stronger than the pRNFLT-VFMS association in glaucomatous eyes with high myopia (p=0.009). However, there were no significant differences between global pVD-VFMS and pRNFLT-VFMS associations in glaucomatous eyes without high myopia (p=0.343). Regionally, the pVD-VFMS association was significantly greater than the pRNFLT-VFMS association at the superonasal, nasal and temporal sectors (all p<0.05) in glaucomatous eyes with high myopia.ConclusionsThe pVD assessment by OCT-A shows a better global and regional correlation with VFMS than a pRNFLT assessment in glaucoma patients with high myopia. The pVD may be a useful parameter in monitoring disease progression of highly myopic glaucomatous eyes.

The optical coherence tomography angiography findings of rheumatoid arthritis patients taking hydroxychloroquine

2018 ◽  
Vol 29 (5) ◽  
pp. 532-537 ◽  
Author(s):  
Dilay Ozek ◽  
Mehmet Onen ◽  
Emine Esra Karaca ◽  
Ahmet Omma ◽  
Ozlem Evren Kemer ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Optical Coherence Tomography ◽  
Visual Field ◽  
Axial Length ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Density ◽  
Optical Coherence ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Purpose: The aim of this study is to measure retinal vessel density and thickness of the macula by optical coherence tomography angiography in patients with rheumatoid arthritis taking hydroxychloroquine. Methods: The study included 40 patients with rheumatoid arthritis taking hydroxychloroquine and 20 age-, gender-, and axial length-matched control subjects. Patients were divided into two groups according to the duration of hydroxychloroquine use. Twenty four of the patients were taking hydroxychloroquine for more than 5 years (Group 1), and the rest of 16 were taking hydroxychloroquine for less than 5 years (Group 2). A total of 20 age- and gender-matched volunteers with similar axial length were selected as Group 3. All of the patients underwent optical coherence tomography angiography, and 3 mm × 3 mm scanning mode was chosen for analyzing vascular density and morphological characteristics on the choriocapillaris layer. In addition, Humphrey visual field 10–2 was evaluated in each subject. Results: The temporal deep vascular density was measured as 48.13% ± 8.5% in Group 1, 54.42% ± 10.3% in Group 2, and 60.35% ± 13.1% in Group 3. Deep temporal and deep hemi-inferior vascular density was significantly lower in Group 1 in comparison with Group 3 (p = 0.041 and p = 0.046, respectively). Visual field testing was normal in all patients. Conclusion: The optical coherence tomography angiography findings showed that the parafoveal deep temporal and deep hemi-inferior vascular plexus density was reduced in patients taking hydroxychloroquine for more than 5 years despite having normal perimetry. This observation, which can be obtained only through optical coherence tomography angiography, may be relevant to the early findings of hydroxychloroquine toxicity.

Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

2020 ◽  
pp. bjophthalmol-2020-316881 ◽  
Author(s):  
Francesco Pichi ◽  
Ester Carreño Salas ◽  
Marc D de Smet ◽  
Vishali Gupta ◽  
Manfred Zierhut ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Quantitative Measurement ◽  
Optical Coherence Tomography Angiography ◽  
Study Group ◽  
Wide Field ◽  
Clinical Use ◽  
Optical Coherence ◽  
Online Questionnaire ◽  
Survey Results ◽  
Definition Of

AimTo standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis.MethodsMembers of the International Uveitis Study Group, of the American Uveitis Society and of the Sociedad Panamericana de Infermedades Oculares that choose to participate responded to an online questionnaire about their preferred terminology when reporting on OCT-A findings in uveitis. The response of individuals with several publications on OCT-A (experts) was compared with uveitis specialists (users) who have less than five publications on the field of uveitis and OCT-A.ResultsA total of 108 uveitis specialists who participated in the survey were included in the analysis. Of those, 23 were considered OCT-A ‘experts’. There was an agreement in both groups for the definition of wide-field (WF)-OCT-A, and definition of neovascularisation in uveitis. Moreover, there was a difference in the responses in other areas, such as quantification of ischaemia, definition of ‘large’ areas of ischaemia or terms to describe decreased OCT-A signal from different causes. There was an unanimous need of ‘users’ and ‘experts’ to distinguish size of decreased OCT-A signal in uveitis, to implement a quantitative measurement of decreased flow specifically for WF-OCT-A and to use different terms for different causes of decreased OCT-A signal.ConclusionsWhile there was considerable agreement in the terminology used by all uveitis experts, significant differences in terminology were noted between ‘users’ and ‘experts’. These differences indicate the need for standardisation of nomenclature among all uveitis specialists both for the purpose of reporting and in clinical use.

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