Comparison of a gene expression profiling strategy to standard clinical work-up for determination of tumour origin in cancer of unknown primary (CUP)

2013 ◽  
Vol 25 (4) ◽  
pp. 239-246 ◽  
Author(s):  
Felipe Ades ◽  
Evandro de Azambuja ◽  
Gedske Daugaard ◽  
Lieveke Ameye ◽  
Camilo Moulin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Clinical Work ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Work Up ◽  
Tumour Origin

Cancer of Unknown Primary: From Immunohistochemistry to Gene Expression Profiling

2012 ◽  
Vol 30 (29) ◽  
pp. e300-e302 ◽  
Author(s):  
Wendy M. Chiang ◽  
Mitesh Kapadia ◽  
Nora V. Laver ◽  
John Scott Nystrom
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary

scholarly journals Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach

2021 ◽  
Vol 11 ◽  
Author(s):  
Xingxiang Pu ◽  
Sa Yang ◽  
Yan Xu ◽  
Bolin Chen ◽  
Qianzhi Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Tumor Tissues ◽  
Therapeutic Decisions ◽  
Accurate Treatment ◽  
Tissue Origin ◽  
Primary Gene

The treatment of cancer of unknown primary (CUP) is a huge challenge for clinicians. Gene expression profiling can help identify the tissue origin of tumors by detecting the expression levels of specific genes in tumor tissues. Herein, we report four CUP cases. All of them have been successfully identified with the corresponding primary tumor sites through gene expression profiling analysis. Then all patients received accurate treatment, providing reference to guide therapeutic decisions to treat CUP tumors in the future.

Cancer of unknown primary site

2016 ◽  
pp. 965-974
Author(s):  
Nicholas Pavlidis ◽  
George Pentheroudakis
Keyword(s):  
Expression Profiling ◽  
Cancer Of Unknown Primary ◽  
Primary Site ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Clinical Intuition ◽  
Genome Wide ◽  
Genetic Signatures ◽  
Genome Wide Expression ◽  
Tumour Origin

This chapter covers cancer of unknown primary site (CUP), and includes information on epidemiology, molecular biology, pathology, and multidisciplinary management of clinicopathological subsets. Previously, these tumours were diagnosed and treated based on clinical presentation, light microscopy and clinical intuition. Today, the majority of cancers of unknown primary site are becoming less unknown, more accurately classified, and appropriately treated by the use of multiplex or genome-wide expression profiling platforms. These techniques allow for precise and correct knowledge of the true tumour origin, leading to more rational and effective treatment. However, there also may be genetic signatures that are primary-independent, pro-metastatic, and possibly CUP-specific.

scholarly journals Gene expression profiling and its use in adenocarcinomas of unknown primary origin: A case report

2015 ◽  
Vol 10 (4) ◽  
pp. 2657-2661
Author(s):  
ANA CEBOLLERO DE MIGUEL ◽  
ROBERTO PAZO CID ◽  
JAVIER MARTINEZ TRUFERO ◽  
ISABEL PAJARES BERNAD ◽  
LOURDES CALERA URQUIZU ◽  
...  
Keyword(s):  
Gene Expression ◽  
Case Report ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Unknown Primary ◽  
Primary Origin ◽  
Unknown Primary Origin
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