Hydrogen Isotope Disequilibrium Among Hydrous Minerals in Eclogites from the Dabie Mountains and the Sulu Terrane

1998 ◽  
Vol 62A (1) ◽  
pp. 481-482
Author(s):  
B. Fu
1999 ◽  
Vol 134 (1) ◽  
pp. 52-66 ◽  
Author(s):  
Bin Fu ◽  
Yong-Fei Zheng ◽  
Zhengrong Wang ◽  
Yilin Xiao ◽  
Bing Gong ◽  
...  

Author(s):  
Jack Rowbotham ◽  
Oliver Lenz ◽  
Holly Reeve ◽  
Kylie Vincent

<p></p><p>Chemicals labelled with the heavy hydrogen isotope deuterium (<sup>2</sup>H) have long been used in chemical and biochemical mechanistic studies, spectroscopy, and as analytical tracers. More recently, demonstration of selectively deuterated drug candidates that exhibit advantageous pharmacological traits has spurred innovations in metal-catalysed <sup>2</sup>H insertion at targeted sites, but asymmetric deuteration remains a key challenge. Here we demonstrate an easy-to-implement biocatalytic deuteration strategy, achieving high chemo-, enantio- and isotopic selectivity, requiring only <sup>2</sup>H<sub>2</sub>O (D<sub>2</sub>O) and unlabelled dihydrogen under ambient conditions. The vast library of enzymes established for NADH-dependent C=O, C=C, and C=N bond reductions have yet to appear in the toolbox of commonly employed <sup>2</sup>H-labelling techniques due to requirements for suitable deuterated reducing equivalents. By facilitating transfer of deuterium atoms from <sup>2</sup>H<sub>2</sub>O solvent to NAD<sup>+</sup>, with H<sub>2</sub> gas as a clean reductant, we open up biocatalysis for asymmetric reductive deuteration as part of a synthetic pathway or in late stage functionalisation. We demonstrate enantioselective deuteration via ketone and alkene reductions and reductive amination, as well as exquisite chemo-control for deuteration of compounds with multiple unsaturated sites.</p><p></p>


Author(s):  
Roger H. Stuewer

In December 1931, Harold Urey discovered deuterium (and its nucleus, the deuteron) by spectroscopically detecting the faint companion lines in the Balmer spectrum of atomic hydrogen that were produced by the heavy hydrogen isotope. In February 1932, James Chadwick, stimulated by the claim of the wife-and-husband team of Irène Curie and Frédéric Joliot that polonium alpha particles cause the emission of energetic gamma rays from beryllium, proved experimentally that not gamma rays but neutrons are emitted, thereby discovering the particle whose existence had been predicted a dozen years earlier by Chadwick’s mentor, Ernest Rutherford. In August 1932, Carl Anderson took a cloud-chamber photograph of a positron traversing a lead plate, unaware that Paul Dirac had predicted the existence of the anti-electron in 1931. These three new particles, the deuteron, neutron, and positron, were immediately incorporated into the experimental and theoretical foundations of nuclear physics.


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