scholarly journals Impact of risk factors on the timing of first postpartum venous thromboembolism: a population-based cohort study from England

Blood ◽  
2014 ◽  
Vol 124 (18) ◽  
pp. 2872-2880 ◽  
Author(s):  
Alyshah Abdul Sultan ◽  
Matthew J. Grainge ◽  
Joe West ◽  
Kate M. Fleming ◽  
Catherine Nelson-Piercy ◽  
...  

Key Points For women with preeclampsia, BMI >30 kg/m2, infection, or those having cesarean delivery, VTE risk remained elevated for 6 weeks postpartum. For women with postpartum hemorrhage or preterm birth, the relative rate of VTE was only increased for the first 3 weeks postpartum.

Blood ◽  
2013 ◽  
Vol 121 (19) ◽  
pp. 3953-3961 ◽  
Author(s):  
Alyshah Abdul Sultan ◽  
Laila J. Tata ◽  
Joe West ◽  
Linda Fiaschi ◽  
Kate M. Fleming ◽  
...  

Key Points Antepartum, we found that established risk factors only had a modest effect on rates of VTE. Postpartum, we found that among other factors, women with stillbirth or preterm birth had high rates of VTE.


Blood ◽  
2014 ◽  
Vol 123 (25) ◽  
pp. 3972-3978 ◽  
Author(s):  
Cheng E. Chee ◽  
Aneel A. Ashrani ◽  
Randolph S. Marks ◽  
Tanya M. Petterson ◽  
Kent R. Bailey ◽  
...  

Key Points VTE recurrence risk in patients with cancer can be stratified by cancer type, stage, stage progression, and presence of leg paresis. Patients with cancer at high VTE recurrence risk should be considered for secondary prophylaxis.


2020 ◽  
Author(s):  
Yanpeng Wu ◽  
Jianhong Pan ◽  
Dong Han ◽  
Lixin Li ◽  
Yanfei Wu ◽  
...  

Abstract Background: Racial and ethnic disparities in stillbirth risk had been documented in most western countries, but it remains unknown in China. This study was to determine whether exist ethnic disparities in stillbirth risk in mainland China.Methods: Pregnancy outcomes and ethnicity data were obtained from the National Free Preconception Health Examination Project (NEPHEP), a nationwide prospective population-based cohort study conducted in Yunnan China from 2010-2018. The Han majority and other four main minorities including Yi, Dai, Miao, Hani were investigated in the analysis. The stillbirth hazards were estimated by life-table analysis. The excess stillbirth risk (ESR) was computed for Chinese minorities using multivariable logistic regression.Results: Compared with other four minorities, women in Han majority were more likely to more educated, less multiparous, and less occupied in agriculture. The pattern of stillbirth hazard of Dai women across different gestation intervals were found to be different from other ethnic groups, especially in 20-23 weeks with 3.2 times higher than Han women. The ESR of the Dai, Hani, Miao, and Yi were 45.05%, 18.70%, -4.17% and 12.28%, respectively. Adjusted for maternal age, education, birth order and other general risk factors, the ethnic disparity still persisted between Dai women and Han women. Adjusted for preterm birth further (gestation age <37 weeks) can reduce 16.91% ESR of Dai women and made the disparity insignificant. Maternal diseases and congenital anomalies explained little for ethnic disparities.Conclusions: We identified the ethnic disparity in stillbirth risk between Dai women and Han women. General risk factors including sociodemographic factors and maternal diseases explained little. Considerable ethnic disparities can be attributed to preterm birth.


Author(s):  
Amen Ness ◽  
Jonathan A. Mayo ◽  
Yasser Y. El-Sayed ◽  
Maurice L. Druzin ◽  
David K. Stevenson ◽  
...  

Objective The study aimed to describe preterm birth (PTB) rates, subtypes, and risk factors in twins compared with singletons to better understand reasons for the decline in PTB rate between 2007 and 2011. Study Design This was a retrospective population-based analysis using the California linked birth certificates and maternal-infant hospital discharge records from 2007 to 2011. The main outcomes were overall, spontaneous (following spontaneous labor or preterm premature rupture of membranes), and medically indicated PTB at various gestational age categories: <37, <32, and 34 to 36 weeks in twins and singletons. Results Among the 2,290,973 singletons and 28,937 twin live births pairs included, overall PTB <37 weeks decreased by 8.46% (6.77–6.20%) in singletons and 7.17% (55.31–51.35%) in twins during the study period. In singletons, this was primarily due to a 24.91% decrease in medically indicated PTB with almost no change in spontaneous PTB, whereas in twins indicated PTB declined 7.02% and spontaneous PTB by 7.39%. Conclusion Recent declines in PTB in singletons appear to be largely due to declines in indicated PTB, whereas both spontaneous and indicated PTB declined in twins. Key Points


Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 1210-1210
Author(s):  
Claire Salomon ◽  
Claire De Moreuil ◽  
Jacob Hannigsberg ◽  
Christophe Trémouilhac ◽  
Guillaume Drugmanne ◽  
...  

Abstract Objective: To determine clinical and hematological risk factors for immediate postpartum hemorrhage (PPH). Design: A cohort study. Setting: Obstetric unit of Brest University Hospital (France). Population: All women who underwent a vaginal delivery between April 1, 2013 and May 29, 2015. Methods: Clinical data were collected by obstetricians or midwives during antenatal care visits, labor and delivery, and recorded by trained research assistants in a standardized electronic case report form. Hematological variables, including immature platelet fraction, were measured from a blood sample systematically performed at the entrance in the delivery room. Main Outcome Measures: Postpartum hemorrhage (PPH), measured with a graduated collector bag, was defined as blood loss of at least 500ml. Results: 2742 women were studied. PPH occurred in 141 (5%) women. Seven clinical factors were independently associated with PPH: pre-eclampsia (OR 5.85, 95%CI 2.02-16.90), multiple pregnancy (OR 3.28 (1.21-8.91), assisted reproduction (OR 2.75, 95%CI 1.45-5.20), ante partum bleeding (OR 2.15, 95%CI 1.24-3.73), post-term delivery (OR 1.93, 95%CI 1.17-3.17), obesity (OR 2.95, 95%CI 1.76-4.93) and episiotomy (OR 2.51, 95%CI 1.63-3.74). Three hematological factors were additionally identified as potential predictive factors for PPH: platelets < 150 000 Giga/L (OR 2.98, 95%CI 1.63-5.46), fibrinogen < 4.5 g/dL (OR 1.86, 95%CI 1.21-2.87) and APTT ratio ≥ 1.1 (OR 2.16, 95%CI 1.31-3.57). Conclusion: Besides classical risk factors, this study highlighted the role of assisted pregnancy and obesity in the PPH occurrence, and identified simple hematological predictive risk factors for PPH. How these parameters could be integrated in a helpful prediction score of PPH remains to be determined. Disclosures Pan-Petesch: LFB: Other: Investigator.


2017 ◽  
Vol 96 (7) ◽  
pp. 852-861 ◽  
Author(s):  
Päivi J. Galambosi ◽  
Mika Gissler ◽  
Risto J. Kaaja ◽  
Veli-Matti Ulander

2016 ◽  
Vol 144 ◽  
pp. 40-45 ◽  
Author(s):  
Myung S. Park ◽  
Sarah E. Perkins ◽  
Grant M. Spears ◽  
Aneel A. Ashrani ◽  
Cynthia L. Leibson ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yanpeng Wu ◽  
Jianhong Pan ◽  
Dong Han ◽  
Lixin Li ◽  
Yanfei Wu ◽  
...  

Abstract Background Racial and ethnic disparities in stillbirth risk had been documented in most western countries, but it remains unknown in China. This study was to determine whether exist ethnic disparities in stillbirth risk in mainland China. Methods Pregnancy outcomes and ethnicity data were obtained from the National Free Preconception Health Examination Project (NEPHEP), a nationwide prospective population-based cohort study conducted in Yunnan China from 2010-2018. The Han majority and other four main minorities including Yi, Dai, Miao, Hani were investigated in the analysis. The stillbirth hazards were estimated by life-table analysis. The excess stillbirth risk (ESR) was computed for Chinese minorities using multivariable logistic regression. Results Compared with other four minorities, women in Han majority were more likely to more educated, less multiparous, and less occupied in agriculture. The pattern of stillbirth hazard of Dai women across different gestation intervals were found to be different from other ethnic groups, especially in 20-23 weeks with 3.2 times higher than Han women. The ESR of the Dai, Hani, Miao, and Yi were 45.05, 18.70, -4.17 and 12.28%, respectively. Adjusted for maternal age, education, birth order and other general risk factors, the ethnic disparity still persisted between Dai women and Han women. Adjusted for preterm birth further (gestation age <37 weeks) can reduce 16.91% ESR of Dai women and made the disparity insignificant. Maternal diseases and congenital anomalies explained little for ethnic disparities. Conclusions We identified the ethnic disparity in stillbirth risk between Dai women and Han women. General risk factors including sociodemographic factors and maternal diseases explained little. Considerable ethnic disparities can be attributed to preterm birth.


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