scholarly journals Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia

Blood ◽  
2015 ◽  
Vol 126 (22) ◽  
pp. 2484-2490 ◽  
Author(s):  
Jane E. Churpek ◽  
Khateriaa Pyrtel ◽  
Krishna-Latha Kanchi ◽  
Jin Shao ◽  
Daniel Koboldt ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Germ Line ◽  
Cumulative Risk ◽  
Genomic Analysis ◽  
Asymptomatic Carriers ◽  
Clonal Hematopoiesis ◽  
Inherited Predisposition ◽  
Key Points ◽  
Acute Myeloid

Key Points Known pathogenic germ line variants in 12 genes can explain nearly 30% of families with inherited predisposition to MDS/AML. Asymptomatic carriers of germ line RUNX1 mutations develop detectable clonal hematopoiesis with a cumulative risk of >80% by age 50 years.

scholarly journals Gilteritinib induces differentiation in relapsed and refractory FLT3-mutated acute myeloid leukemia

2019 ◽  
Vol 3 (10) ◽  
pp. 1581-1585 ◽  
Author(s):  
Christine M. McMahon ◽  
Jonathan Canaani ◽  
Bryan Rea ◽  
Rachel L. Sargent ◽  
Julianne N. Qualtieri ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Genetic Evolution ◽  
Clonal Hematopoiesis ◽  
Key Points ◽  
Acute Myeloid

Key Points Gilteritinib induces 2 distinct marrow responses in FLT3-mutated AML: responses with and without differentiation. Ongoing clonal hematopoiesis is ubiquitous during gilteritinib therapy and may promote genetic evolution and drug resistance.

scholarly journals Index case of acute myeloid leukemia in a family harboring a novel CEBPA germ line mutation

2017 ◽  
Vol 1 (8) ◽  
pp. 500-503 ◽  
Author(s):  
Jodi Ram ◽  
Gabrielle Flamm ◽  
Marlene Balys ◽  
Umayal Sivagnanalingam ◽  
Paul G. Rothberg ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Germ Line ◽  
Index Case ◽  
Key Points ◽  
History Of ◽  
Germ Line Mutation ◽  
Cebpa Mutations ◽  
Line Analysis ◽  
Acute Myeloid

Key Points The persistence of a CEBPA mutation at the time of complete remission warrants germ line analysis. Not all patients harboring germ line CEBPA mutations have a family history of AML.

scholarly journals Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response

Nature Cancer ◽  
2021 ◽  
Vol 2 (5) ◽  
pp. 527-544 ◽  
Author(s):  
Marina Scheller ◽  
Anne Kathrin Ludwig ◽  
Stefanie Göllner ◽  
Christian Rohde ◽  
Stephen Krämer ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Clonal Hematopoiesis ◽  
Viral Mimicry ◽  
Acute Myeloid

scholarly journals CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia

Blood ◽  
2013 ◽  
Vol 122 (7) ◽  
pp. 1316-1324 ◽  
Author(s):  
Margaret L. Green ◽  
Wendy M. Leisenring ◽  
Hu Xie ◽  
Roland B. Walter ◽  
Marco Mielcarek ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Early Relapse ◽  
Relapse Risk ◽  
Allogeneic Hct ◽  
Increased Risk ◽  
Key Points ◽  
Cmv Reactivation ◽  
Reduced Risk ◽  
Acute Myeloid

Key Points CMV reactivation after HCT is associated with a reduced risk of early relapse in patients with AML but not other disease groups. The benefit, however, is offset by an increased risk of nonrelapse mortality.

scholarly journals Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

Blood ◽  
2015 ◽  
Vol 125 (15) ◽  
pp. 2386-2396 ◽  
Author(s):  
Francis Mussai ◽  
Sharon Egan ◽  
Joseph Higginbotham-Jones ◽  
Tracey Perry ◽  
Andrew Beggs ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Therapeutic Target ◽  
Myeloid Leukemia ◽  
Leukemia Blast ◽  
Key Points ◽  
Acute Myeloid Leukemia Blast ◽  
Acute Myeloid ◽  
Novel Therapeutic

Key Points Arginase depletion with BCT-100 pegylated recombinant human arginase is cytotoxic to AML blasts.

scholarly journals Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Blood ◽  
2017 ◽  
Vol 129 (6) ◽  
pp. 771-782 ◽  
Author(s):  
Jason A. Powell ◽  
Alexander C. Lewis ◽  
Wenying Zhu ◽  
John Toubia ◽  
Melissa R. Pitman ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Key Points ◽  
Dependent Cell ◽  
Acute Myeloid

Key Points Inhibition of SPHK1 in human AML cells induces MCL1 degradation and caspase-dependent cell death. SPHK1 inhibitors reduce leukemic burden and prolong survival in orthotopic patient-derived xenografts of AML.

scholarly journals Disseminated intravascular coagulation at diagnosis is a strong predictor for thrombosis in acute myeloid leukemia

Blood ◽  
2016 ◽  
Vol 128 (14) ◽  
pp. 1854-1861 ◽  
Author(s):  
Eduard J. Libourel ◽  
Clara P. W. Klerk ◽  
Yvette van Norden ◽  
Moniek P. M. de Maat ◽  
Marieke J. Kruip ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Disseminated Intravascular Coagulation ◽  
Arterial Thrombosis ◽  
Myeloid Leukemia ◽  
Strong Predictor ◽  
Newly Diagnosed ◽  
Intravascular Coagulation ◽  
Key Points ◽  
D Dimer ◽  
Acute Myeloid

Key Points A high D-dimer level strongly predicts symptomatic venous and arterial thrombosis in newly diagnosed AML. Thrombosis occurs in up to 10% of patients with newly diagnosed AML.

scholarly journals Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia

Blood ◽  
2016 ◽  
Vol 127 (11) ◽  
pp. 1449-1458 ◽  
Author(s):  
Weiwei Shen ◽  
Mrinal M. Patnaik ◽  
Autumn Ruiz ◽  
Stephen J. Russell ◽  
Kah-Whye Peng
Keyword(s):  
Acute Myeloid Leukemia ◽  
Vesicular Stomatitis Virus ◽  
Myeloid Leukemia ◽  
Therapeutic Outcome ◽  
Key Points ◽  
Vesicular Stomatitis ◽  
Immunocompetent Mice ◽  
Acute Myeloid

Key Points IV therapy with oncolytic VSV-IFNβ-NIS virus extends survival of immunocompetent mice with AML. The therapeutic outcome of VSV-IFNβ-NIS–treated mice with AML is augmented by anti-PD-L1 immunotherapy.

scholarly journals CDX2 regulates ACE expression in blood development and leukemia cells

2021 ◽  
Vol 5 (7) ◽  
pp. 2012-2016
Author(s):  
Reine El Omar ◽  
Emmanuelle Julien ◽  
Katia Biasch ◽  
Blandine Guffroy ◽  
Bruno Lioure ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Homeobox Gene ◽  
Mouse Embryos ◽  
Leukemia Cells ◽  
Converting Enzyme ◽  
Key Points ◽  
Human Acute Myeloid Leukemia ◽  
Human And Mouse ◽  
Acute Myeloid

Key Points Expression of caudal-related homeobox gene 2 (CDX2) and angiotensin-converting enzyme (ACE) correlates during hematopoietic emergence. This emergence occurs in human and mouse embryos and in human acute myeloid leukemia; CDX2 homeoprotein also binds to the ACE promoter.

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