Clonal rearrangement of the T cell receptor beta gene in the circulating lymphocytes of erythrodermic follicular mucinosis

Follicular mucinosis is a condition characterized by the abnormal accumulation of acidic mucopolysaccharides in hair follicles. It is classically described as occurring idiopathically in young persons and within the infiltrates of mycosis fungoides in older individuals. We report a 12-year-old girl who had erythrodermic follicular mucinosis, hypereosinophilia, circulating Sezary cells, and both immunophenotypic and genotypic evidence of T cell neoplasia. Erythrodermic follicular mucinosis may represent an unusual variant of the Sezary syndrome, which to date has not been described in children or adolescents.

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Clonal rearrangement of the T cell receptor beta gene in the circulating lymphocytes of erythrodermic follicular mucinosis

Blood ◽

10.1182/blood.v71.5.1329.1329 ◽

1988 ◽

Vol 71 (5) ◽

pp. 1329-1333 ◽

Cited By ~ 42

Author(s):

PE LeBoit ◽

EA Abel ◽

ML Cleary ◽

RT Hoppe ◽

ML Williams ◽

...

Keyword(s):

T Cell ◽

Cell Receptor ◽

Hair Follicles ◽

Older Individuals ◽

Abnormal Accumulation ◽

Circulating Lymphocytes ◽

Unusual Variant ◽

T Cell Receptor Beta ◽

Sézary Cells ◽

Receptor Beta

Abstract Follicular mucinosis is a condition characterized by the abnormal accumulation of acidic mucopolysaccharides in hair follicles. It is classically described as occurring idiopathically in young persons and within the infiltrates of mycosis fungoides in older individuals. We report a 12-year-old girl who had erythrodermic follicular mucinosis, hypereosinophilia, circulating Sezary cells, and both immunophenotypic and genotypic evidence of T cell neoplasia. Erythrodermic follicular mucinosis may represent an unusual variant of the Sezary syndrome, which to date has not been described in children or adolescents.

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156 Clonal T-cell composition, detected by analysis of the T-cell receptor beta chain, is exclusively present in dilated cardiomyopathy, and not associated with enteroviral or adenoviral infection

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(03)90086-5 ◽

2003 ◽

Vol 2 (1) ◽

pp. 28

Author(s):

M NOUTSIAS ◽

J BLOHM ◽

C ASSAF ◽

N BIDGELIISSAZADEH ◽

M HUMMEL ◽

...

Keyword(s):

T Cell ◽

Dilated Cardiomyopathy ◽

T Cell Receptor ◽

Cell Receptor ◽

Beta Chain ◽

Adenoviral Infection ◽

Cell Composition ◽

T Cell Receptor Beta ◽

Receptor Beta

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T-Cell Receptor Beta Locus

10.32388/zk1hv0 ◽

2020 ◽

Author(s):

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

T Cell Receptor Beta ◽

Receptor Beta

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Gene melting curve spectratyping technique in analyzing polymorphism of T-cell receptor beta chain variable region in CD4+ T cells of tuberculosis patients

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2013.01317 ◽

2014 ◽

Vol 33 (12) ◽

pp. 1317-1322

Author(s):

Dong-mei ZHANG ◽

Xiao-lei SUN ◽

Yi-nong DUAN ◽

Wei TANG ◽

Ming-ming ZHOU ◽

...

Keyword(s):

T Cells ◽

T Cell ◽

T Cell Receptor ◽

Melting Curve ◽

Variable Region ◽

Cell Receptor ◽

Beta Chain ◽

Tuberculosis Patients ◽

T Cell Receptor Beta ◽

Receptor Beta

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The T Cell Receptor (TRB) Locus in Tursiops truncatus: From Sequence to Structure of the Alpha/Beta Heterodimer in the Human/Dolphin Comparison

Genes ◽

10.3390/genes12040571 ◽

2021 ◽

Vol 12 (4) ◽

pp. 571

Author(s):

Giovanna Linguiti ◽

Sofia Kossida ◽

Ciro Leonardo Pierri ◽

Joumana Jabado-Michaloud ◽

Geraldine Folch ◽

...

Keyword(s):

Amino Acids ◽

T Cell ◽

T Cell Receptor ◽

Tursiops Truncatus ◽

Cell Receptor ◽

Sequence Alignments ◽

T Cell Receptor Beta ◽

Alpha Beta ◽

Receptor Beta ◽

Complementarity Determining Region

The bottlenose dolphin (Tursiops truncatus) belongs to the Cetartiodactyla and, similarly to other cetaceans, represents the most successful mammalian colonization of the aquatic environment. Here we report a genomic, evolutionary, and expression study of T. truncatus T cell receptor beta (TRB) genes. Although the organization of the dolphin TRB locus is similar to that of the other artiodactyl species, with three in tandem D-J-C clusters located at its 3′ end, its uniqueness is given by the reduction of the total length due essentially to the absence of duplications and to the deletions that have drastically reduced the number of the germline TRBV genes. We have analyzed the relevant mature transcripts from two subjects. The simultaneous availability of rearranged T cell receptor α (TRA) and TRB cDNA from the peripheral blood of one of the two specimens, and the human/dolphin amino acids multi-sequence alignments, allowed us to calculate the most likely interactions at the protein interface between the alpha/beta heterodimer in complex with major histocompatibility class I (MH1) protein. Interacting amino acids located in the complementarity-determining region according to IMGT numbering (CDR-IMGT) of the dolphin variable V-alpha and beta domains were identified. According to comparative modelization, the atom pair contact sites analysis between the human MH1 grove (G) domains and the T cell receptor (TR) V domains confirms conservation of the structure of the dolphin TR/pMH.

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