scholarly journals CLL dedifferentiation to clonally related myeloid cells

2020 ◽  
Vol 4 (24) ◽  
pp. 6169-6174
Author(s):  
Qianze Dong ◽  
Yan Xiu ◽  
Aaron Bossler ◽  
Sergei Syrbu ◽  
Hongming Wang ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Progenitor Cells ◽  
Myeloid Cells ◽  
Lymphocytic Leukemia ◽  
Key Points ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Key Points Common progenitor cells exist in clonally related concomitant chronic lymphocytic leukemia and acute myeloid leukemias. CLL cells dedifferentiated to clonally related myeloid cells posttransplantation.

scholarly journals Identification of Bruton’s tyrosine kinase as a therapeutic target in acute myeloid leukemia

Blood ◽  
2014 ◽  
Vol 123 (8) ◽  
pp. 1229-1238 ◽  
Author(s):  
Stuart A. Rushworth ◽  
Megan Y. Murray ◽  
Lyubov Zaitseva ◽  
Kristian M. Bowles ◽  
David J. MacEwan
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chronic Lymphocytic Leukemia ◽  
Tyrosine Kinase ◽  
Myeloid Leukemia ◽  
Lymphocytic Leukemia ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Key Points ◽  
Acute Myeloid

Key Points Inhibition of Bruton’s tyrosine kinase is as effective in vitro against AML as chronic lymphocytic leukemia. Ibrutinib shows activity in AML because Bruton’s tyrosine kinase is constitutively active.

scholarly journals Chronic lymphocytic leukemia cells induce defective LFA-1–directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

Blood ◽  
2013 ◽  
Vol 121 (14) ◽  
pp. 2704-2714 ◽  
Author(s):  
Alan G. Ramsay ◽  
Rachel Evans ◽  
Shahryar Kiaii ◽  
Lena Svensson ◽  
Nancy Hogg ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Cell Motility ◽  
Rho Gtpase ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Key Points ◽  
Gtpase Activation ◽  
Activation Signaling

Key Points CLL cells induce defects in T-cell LFA-1–mediated migration by altering Rho GTPase activation signaling, downregulating RhoA and Rac1, and upregulating Cdc42. Lenalidomide repairs these T-cell defects by restoring normal Rho GTPase activation signaling.

scholarly journals A Case of Acute Myeloid Leukemia Concurrent With Untreated Chronic Lymphocytic Leukemia

2017 ◽  
Vol 37 (4) ◽  
pp. 336-338
Author(s):  
Hye-Young Lee ◽  
Chan-Jeoung Park ◽  
Enkyung You ◽  
Young-Uk Cho ◽  
Seongsoo Jang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Chronic Lymphocytic Leukemia ◽  
Myeloid Leukemia ◽  
Lymphocytic Leukemia ◽  
Acute Myeloid

scholarly journals Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia

Blood ◽  
2014 ◽  
Vol 124 (3) ◽  
pp. 453-462 ◽  
Author(s):  
Mohini Rajasagi ◽  
Sachet A. Shukla ◽  
Edward F. Fritsch ◽  
Derin B. Keskin ◽  
David DeLuca ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Dna Sequencing ◽  
Lymphocytic Leukemia ◽  
Class I ◽  
Massively Parallel ◽  
Central Tolerance ◽  
Key Points ◽  
Tumor Specificity ◽  
Massively Parallel Dna Sequencing ◽  
Systematic Identification

Key Points Tumor neoantigens are a promising class of immunogens based on exquisite tumor specificity and the lack of central tolerance against them. Massively parallel DNA sequencing with class I prediction enables systematic identification of tumor neoepitopes (including from CLL).

scholarly journals Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia

Blood ◽  
2018 ◽  
Vol 132 (2) ◽  
pp. 170-178 ◽  
Author(s):  
Md Kamrul Hasan ◽  
Jian Yu ◽  
George F. Widhopf ◽  
Laura Z. Rassenti ◽  
Liguang Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Key Points

Key Points Wnt5a enhances activation of Rac1/2 by inducing ROR1 to interact with DOCK2. ROR1-DOCK2 interaction contributes to Wnt5a-enhanced CLL cell proliferation.

scholarly journals Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Blood ◽  
2018 ◽  
Vol 131 (23) ◽  
pp. 2541-2551 ◽  
Author(s):  
Geffen Kleinstern ◽  
Nicola J. Camp ◽  
Lynn R. Goldin ◽  
Celine M. Vachon ◽  
Claire M. Vajdic ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Risk Score ◽  
Clinical Impact ◽  
Lymphocytic Leukemia ◽  
Polygenic Risk Score ◽  
Polygenic Risk ◽  
Key Points ◽  
High Discrimination

Key Points PRS, based on the known CLL loci, predicts CLL risk with high discrimination. This PRS predicts risk of monoclonal B-cell lymphocytosis, a precursor to CLL and a condition that has clinical impact beyond risk for CLL.

Sign in / Sign up

Export Citation Format

Share Document