Postnatal corticosteroids and lung function at school age in very prematurely born infants

Author(s):  
Christopher Harris ◽  
Sanja Zivanovic ◽  
Mireia Alcazar-Paris ◽  
Jessica Lo ◽  
Alan Lunt ◽  
...  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Engi F. Attia ◽  
Hellen Moraa ◽  
Elizabeth Maleche-Obimbo ◽  
Dalton Wamalwa ◽  
Laurén A. Gómez ◽  
...  

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-215515
Author(s):  
Hélène Amazouz ◽  
Nicolas Bougas ◽  
Michel Thibaudon ◽  
Guillaume Lezmi ◽  
Nicole Beydon ◽  
...  

BackgroundDaily levels of ambient air pollution and pollen may affect lung function but have rarely been studied together. We investigated short-term exposure to pollen and air pollution in relation to lung function in school-age children from a French population-based birth cohort.MethodsThis study included 1063 children from the PARIS (Pollution and Asthma Risk: an Infant Study) cohort whose lung function and FeNO measurements were performed at age 8 years old. Exposure data were collected up to 4 days before testing. We estimated daily total pollen concentration, daily allergenic risk indices for nine pollen taxa, as well as daily concentrations of three air pollutants (particulate matter less than 10 µm (PM10), nitrogen dioxide (NO2), ozone (O3)). Children with similar pollen and air pollution exposure were grouped using multidimensional longitudinal cluster analysis. Associations between clusters of pollen and air pollution exposure and respiratory indices (FEV1, FVC, FeNO) were studied using multivariable linear and logistic regression models adjusted for potential confounders.ResultsFour clusters of exposure were identified: no pollen and low air pollution (Cluster 1), grass pollen (Cluster 2), PM10 (Cluster 3) and birch/plane-tree pollen with high total pollen count (Cluster 4). Compared with children in Cluster 1, children in Cluster 2 had significantly lower FEV1 and FVC levels, and children from Cluster 3 had higher FeNO levels. For FEV1 and FVC, the associations appeared stronger in children with current asthma. Additional analysis suggested a joint effect of grass pollen and air pollution on lung function.ConclusionDaily ambient chemical and biological air quality could adversely influence lung function in children.


2020 ◽  
Vol 110 (1) ◽  
pp. 219-221
Author(s):  
Annukka Holster ◽  
Riikka Riikonen ◽  
Johanna Teräsjärvi ◽  
Matti Korppi ◽  
Kirsi Nuolivirta ◽  
...  

2020 ◽  
Vol 9 (10) ◽  
pp. 3345
Author(s):  
Manuel Sanchez-Solis ◽  
Maria Soledad Parra-Carrillo ◽  
Pedro Mondejar-Lopez ◽  
Patricia W Garcia-Marcos ◽  
Luis Garcia-Marcos

Background: The aim of the study is to assess whether lung function of infants born preterm predicts wheezing in pre-school age. Methods: A survey of the core wheezing questionnaire of the International Study on Asthma and Allergy in Children was administered to parents of preterm newborns, to whom lung function tests were performed at a corrected age of six months, and who, at the time of the survey, were between three and nine years of age. Results: Low values of all lung function parameters measured, except FVC, were predictors of wheezing at some time in life, (FEV0.5 OR: 0.62 (95%CI 0.39; 0.995); FEV0.5/FVC OR: 0.73 (0.54; 0.99)) FEF75 OR: 0.60 [0.37; 0.93]; FEF25-75 OR: 0.57 (0.37; 0.89)); and of wheezing in the past year (FEV0.5 OR: 0.36 (0.17; 0.76); FEV0.5/FVC OR: 0.59 (0.38; 0.93); FEF75 OR: 0.38 [0.19; 0.76]; FEF25-75 OR: 0.35 (0.17; 0.70). In addition, FEV0.5/FVC values lower than the lowest limit of normality, were predictive of hospital admissions due to wheezing (OR: 3.07; (1.02; 9.25)). Conclusions: Limited lung function in infancy is predictive of both future wheezing and hospitalization for a wheezing episode.


2010 ◽  
Vol 181 (9) ◽  
pp. 969-974 ◽  
Author(s):  
Sarah J. Kotecha ◽  
W. John Watkins ◽  
Jonathan Heron ◽  
John Henderson ◽  
Frank D. Dunstan ◽  
...  

Author(s):  
Marina Praprotnik ◽  
Maja Pavčnik ◽  
Malena Aldeco ◽  
Matevž Srpčič ◽  
Uroš Krivec

Author(s):  
Shannon Simpson ◽  
Karla Logie ◽  
Maureen Verheggen ◽  
Christopher O'Dea ◽  
Andrew Wilson ◽  
...  

1991 ◽  
Vol 144 (3_pt_1) ◽  
pp. 655-662 ◽  
Author(s):  
Gerald L. Strope ◽  
Paul W. Stewart ◽  
Frederick W. Henderson ◽  
Sally S. Ivins ◽  
Helen C. Stedman ◽  
...  

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