Association between lung function of school age children and short-term exposure to air pollution and pollen: the PARIS cohort

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-215515
Author(s):  
Hélène Amazouz ◽  
Nicolas Bougas ◽  
Michel Thibaudon ◽  
Guillaume Lezmi ◽  
Nicole Beydon ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
School Age Children ◽  
School Age ◽  
Short Term ◽  
Short Term Exposure ◽  
Air Pollution Exposure ◽  
Total Pollen ◽  
Pollution Exposure ◽  
Cluster 2

BackgroundDaily levels of ambient air pollution and pollen may affect lung function but have rarely been studied together. We investigated short-term exposure to pollen and air pollution in relation to lung function in school-age children from a French population-based birth cohort.MethodsThis study included 1063 children from the PARIS (Pollution and Asthma Risk: an Infant Study) cohort whose lung function and FeNO measurements were performed at age 8 years old. Exposure data were collected up to 4 days before testing. We estimated daily total pollen concentration, daily allergenic risk indices for nine pollen taxa, as well as daily concentrations of three air pollutants (particulate matter less than 10 µm (PM10), nitrogen dioxide (NO2), ozone (O3)). Children with similar pollen and air pollution exposure were grouped using multidimensional longitudinal cluster analysis. Associations between clusters of pollen and air pollution exposure and respiratory indices (FEV1, FVC, FeNO) were studied using multivariable linear and logistic regression models adjusted for potential confounders.ResultsFour clusters of exposure were identified: no pollen and low air pollution (Cluster 1), grass pollen (Cluster 2), PM10 (Cluster 3) and birch/plane-tree pollen with high total pollen count (Cluster 4). Compared with children in Cluster 1, children in Cluster 2 had significantly lower FEV1 and FVC levels, and children from Cluster 3 had higher FeNO levels. For FEV1 and FVC, the associations appeared stronger in children with current asthma. Additional analysis suggested a joint effect of grass pollen and air pollution on lung function.ConclusionDaily ambient chemical and biological air quality could adversely influence lung function in children.

scholarly journals Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Luc Int Panis ◽  
Eline B Provost ◽  
Bianca Cox ◽  
Tijs Louwies ◽  
Michelle Laeremans ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Repeated Measures ◽  
Healthy Adults ◽  
Short Term ◽  
Air Pollution Exposure ◽  
Pollution Exposure

Respiratory Effects of Particulate Matter Exposure During Short-Term Cycling Among Healthy Adults in Three Chinese Cities

2020 ◽  
Author(s):  
Lejian He ◽  
Laijun Zhao ◽  
Yonghong Liu ◽  
Zhaowen Qiu ◽  
H. Oliver Gao
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Lung Function ◽  
Fine Particles ◽  
Aerodynamic Diameter ◽  
Short Term ◽  
Respiratory Effects ◽  
Air Pollution Exposure ◽  
Pollution Exposure ◽  
The Impact

Abstract Background: Cycling to work has been promoted as a green commute in many countries because of its reduced congestion relative to that of cars and its reduced environmental impact on air pollution. However, cyclists might be exposed to higher air pollution, causing adverse health effects. Few studies have examined the respiratory effects of traffic-related air pollution exposure during short-term cycling, especially in developing countries with heavy air pollution. The aim of this study was to assess the impact of air pollution exposure on lung function while cycling in traffic. Methods: Twenty-five healthy adults in total cycled on a specified route in each of three Chinese cities during four periods of a day. Lung function measures were collected immediately before and after cycling. Real-time particulate matter (PM) and the particle number count (PNC) for particles with different sizes were measured along each cycling route, while ambient sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), and carbon monoxide (CO) levels were measured at the nearest stations. Mixed-effect models were used to estimate the impact of short-term air pollution exposure on participants’ lung function measures during cycling. Results: We found that an interquartile increase in particulate matter consisting of fine particles (PM1, aerodynamic diameter £ 1 mm; and PM2.5, aerodynamic diameter £ 2.5 mm) was associated with a significant decrease in forced vital capacity (FVC) (PM1, –5.61%, p = 0.021; PM2.5, –5.57%, p = 0.022). Interquartile increases in the 99th percentile of PNC for fine particles (aerodynamic diameter 0.3–0.4 mm) also had significant negative associations with FVC (0.3 mm, –5.13%, p = 0.041; 0.35 mm, –4.81%, p = 0.045; 0.4 mm, –4.59%, p = 0.035). We also observed significant inverse relationships between ambient CO levels and FVC (–5.78%, p = 0.015).Conclusions: Our results suggest that short-term exposure to fine particles and CO while cycling in traffic contributes to a reduction in FVC of cyclists.

scholarly journals Potential Short-Term Air Pollution Effects on Rheumatoid Arthritis Activity in Metropolitan Areas in the North of Italy: A Cross-Sectional Study

2021 ◽  
Vol 18 (16) ◽  
pp. 8490
Author(s):  
Francesca Ingegnoli ◽  
Tania Ubiali ◽  
Tommaso Schioppo ◽  
Valentina Longo ◽  
Antonella Murgo ◽  
...  
Keyword(s):  
Air Pollution ◽  
Disease Activity ◽  
Cross Sectional Study ◽  
Short Term ◽  
Cross Sectional ◽  
Short Term Exposure ◽  
Air Pollution Exposure ◽  
Synthetic Dmards ◽  
Pollution Exposure ◽  
The Impact

Rheumatoid arthritis (RA) flare is related to increased joint damage, disability, and healthcare use. The impact of short-term air pollution exposure on RA disease activity is still a matter of debate. In this cross-sectional study, we investigated whether short-term exposure to particulate matter (PM)10, PM2.5, nitrogen dioxide (NO2), and ozone (O3) affected RA disease activity (DAS28 and SDAI) in 422 consecutive RA residents in Lombardy, North of Italy. Air pollutant concentrations, estimated by Regional Environmental Protection Agency (Lombardy—Italy) at the municipality level, were used to assign short-term exposure from the day of enrolment, back to seven days. Some significant negative associations emerged between RA disease activity, PM10, and NO2, whereas some positive associations were observed for O3. Patients were also stratified according to their ongoing Disease-Modifying anti-Rheumatic Drugs (DMARDs) treatment: no DMARDs (n = 25), conventional synthetic DMARDs (n = 108), and biological or targeted synthetic DMARDs (n = 289). Therapy interaction seemed partially able to influence the relationship between short-term air pollution exposure and RA disease activity (PM2.5 levels and DAS28 at the day of the visit-O3 levels and disease activity scores for the seven days before the evaluation). According to our results, the impact of short-term air pollution exposure (seven days) minimally impacts disease activity. Moreover, our study suggests therapy could alter the response to environmental factors. Further evidence is needed to elucidate determinants of RA flare and its management.

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