Clinical spectrum of the osmotic-controlled release oral delivery system (OROS), an advanced oral delivery form

2006 ◽  
Vol 22 (10) ◽  
pp. 1879-1892 ◽  
Author(s):  
Robert Conley ◽  
Suneel K. Gupta ◽  
Gayatri Sathyan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Clinical Spectrum ◽  
Oral Delivery System

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

Controlled release of cyclosporin A from liposomes-in-microspheres as an oral delivery system

2006 ◽  
Vol 11 (6) ◽  
pp. 526-529 ◽  
Author(s):  
Hee-Jung Park ◽  
Chang-Moon Lee ◽  
Yong-Bok Lee ◽  
Ki-Young Lee
Keyword(s):  
Controlled Release ◽  
Cyclosporin A ◽  
Delivery System ◽  
Oral Delivery ◽  
Oral Delivery System

scholarly journals Osmotic controlled drug delivery system (OSMO technology) and its impact on diabetes care

2020 ◽  
Vol 9 (1) ◽  
pp. 303
Author(s):  
Rajesh Rajput ◽  
K. M. K. Prasanna Kumar ◽  
D. S. Arya ◽  
A. K. Das ◽  
A. H. Zargar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Delivery ◽  
Controlled Drug Delivery ◽  
Special Focus ◽  
Sustained Delivery ◽  
Oral Delivery System ◽  
Prolonged Duration

Recently, focus on the development of controlled release drug delivery system has increased, as existing drugs exhibit certain pharmacokinetic limitations. The major goal of designing sustained release formulations is to improve the drug performance by prolonged duration of drug action, decreased frequency of dosing and reduced side effects by using smallest quantity of drug administered by the most suitable route. Osmotic-controlled release oral delivery system (OSMO technology) is the most promising strategy based system for sustained delivery of drug. Drug can be delivered in a controlled manner over a long period of time by the process of osmosis. Osmotic drug delivery system appears to be a promising solution for the limitations of conventional extended release formulations by virtue of their distinguished technological features. The present review describes briefly about various controlled drug delivery systems with special focus on advantages of osmotic-controlled release oral delivery system related to diabetes therapy and improved compliance.

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