Double-blind, double-dummy randomized, multi-centre clinical assessment of the efficacy, tolerability and dose-effect relationship of sulodexide in chronic venous insufficiency

1993 ◽  
Vol 13 (2) ◽  
pp. 96-108 ◽  
Author(s):  
M. Saviano ◽  
O. Maleti ◽  
L. Liguori
Keyword(s):  
Clinical Assessment ◽  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Dose Effect ◽  
Double Blind ◽  
Effect Relationship ◽  
Relationship Of

Clinical Strategy for Optimal Traditional Chinese Medicine (TCM) Herbal Dose Selection in Disease Therapeutics: Expert Consensus on Classic TCM Herbal Formula Dose Conversion

2015 ◽  
Vol 43 (08) ◽  
pp. 1515-1524 ◽  
Author(s):  
Lin-Hua Zha ◽  
Li-Sha He ◽  
Feng-Mei Lian ◽  
Zhong Zhen ◽  
Hang-Yu Ji ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Measurement System ◽  
Expert Consensus ◽  
Dose Effect ◽  
Herbal Formula ◽  
Dose Selection ◽  
Effect Relationship ◽  
Weight Measurement ◽  
Relationship Of

The clinical therapeutics of traditional Chinese medicine (TCM) constitutes a complicated process which involves theory, diagnosis, and formula prescription with specific herbal dosage. Zhang Zhong-Jing’s classic work, Treatise on Febrile and Miscellaneous Diseases, has been influencing TCM practice for almost 2000 years. However, during this extended period of time in Chinese history, the Chinese weight measurement system experienced noticeable changes. This change in the weight measurement system inevitably, and perhaps even negatively, affected TCM herbal dosage determination and treatment outcome. Thus, in modern society, a full understanding of the accuracy of herbal dose selection has a critical importance in the TCM daily practice of delivering the best treatment to the patients suffering from different illnesses. In the 973 Project of the Chinese National Basic Research Program, expert consensus on classic TCM formula dose conversion has been reached based on extensive literature review and discussion on the dose–effect relationship of classic TCM formulas. One “liang” (两) in classic TCM formulas is equivalent to 13.8[Formula: see text]g. However, based on many TCM basic and clinical studies of variable herbal formula prescriptions and herbal drug preparations, the rule of one liang equals 13.8[Formula: see text]g should be adjusted according to different disease conditions. Recommended by the committee on TCM formula dose–effect relationship of the China Association of Chinese Medicine and the World Federation of Chinese Medicine Societies, the following expert consensus has been reached: (i) One liang converts to 6–9[Formula: see text]g for the severely and critically ill patients. (ii) One liang converts to 3–6[Formula: see text]g for the patients suffering from chronic diseases. (iii) One liang converts to 1–3[Formula: see text]g in preventive medicine. The above conversions should be used as a future TCM practice guideline. Using this recommended guideline should enhance the effectiveness of daily TCM practice.

scholarly journals Characteristics and dose‐effect relationship of clinical gamma‐hydroxybutyrate intoxication: A case series

2021 ◽  
Author(s):  
Madelaine Abid ◽  
Jana Kietzerow ◽  
Stefanie Iwersen‐Bergmann ◽  
Tino Schnitgerhans ◽  
Hilke Andresen‐Streichert
Keyword(s):  
Case Series ◽  
Dose Effect ◽  
Effect Relationship ◽  
Gamma Hydroxybutyrate ◽  
Relationship Of

scholarly journals Chronic Venous Insufficiency (CVI) - A Study of 100 Cases

1970 ◽  
Vol 9 (1) ◽  
pp. 20-26
Author(s):  
MM Shahin-Ul-Islam ◽  
Md Zahirul Haque ◽  
Saki Md Jakiul Alam ◽  
Mesbahuddin Noman ◽  
FM Siddiqui
Keyword(s):  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Leg Pain ◽  
Advanced Stage ◽  
College Hospital ◽  
Prolonged Standing ◽  
Burning Pain ◽  
Significant Difference ◽  
Ceap Classification ◽  
Relationship Of

This study was carried out in the out patient department of Dhaka Medical College Hospital. 100 patients presented with chronic venous insufficiency during the period of January 2005 to June 2005 were studied to find out the various modes of presentation, risk factors and relationship of symptoms with age, sex and Body Mass Index of the patients. It was found that, maximum patients presented with heaviness in the leg (87%), followed by aching leg pain (75%), leg swelling (70%), cramping leg pain (68%), tiredness (48%), burning pain (43%), engorged leg vein (39%), restless leg at night (21%), throbbing leg pain (18%), itching (13%), various skin changes without active ulceration (7%) and active leg ulceration only 3% of cases. Increasing age of the patients, obesity, increasing number of pregnancy, prolonged standing and sitting position at work were found to be positively correlated with CVI. Advanced age is associated with more advanced stage of CVI according to clinical CEAP classification. There is almost equal sex distribution among the stages of CVI except in advanced stage, in stage C4, C5 and C6 there is 10 patients out of them 9 are male and only 1 is female. Relationship of symptoms with BMI of the patients were also sort out and found that, in C3 group of CEAP classification out of 61 patients 46 are obese according to BMI, of which 32 are female and 14 are male and only 17 patients have BMI within normal range, but in other group there is no significant difference in incidence between two groups.   DOI = 10.3329/jom.v9i1.1421 J MEDICINE 2008; 9 : 20-26

Dose-effect Relationship of the β-Agonists Fenoterol and Salbutamol in Patients With Asthma

CHEST Journal ◽  
1994 ◽  
Vol 105 (6) ◽  
pp. 1738-1742 ◽  
Author(s):  
Michael T. Newhouse ◽  
Myrna B. Dolovich ◽  
Farouk Kazim
Keyword(s):  
Dose Effect ◽  
Effect Relationship ◽  
Relationship Of

Dose-Effect Relationship of ZnPc-PDT on Tumor Cells In Vitro

2017 ◽  
Vol 44 (3) ◽  
pp. 0307001
Author(s):  
杨 曼 Yang Man ◽  
邢力允 Xing Liyun ◽  
高卫栋 Gao Weidong ◽  
顾月清 Gu Yueqing
Keyword(s):  
Tumor Cells ◽  
Dose Effect ◽  
Effect Relationship ◽  
Relationship Of

scholarly journals Effect of topiramate on eating behaviours in Prader-Willi syndrome: TOPRADER double-blind randomised placebo-controlled study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Angèle Consoli ◽  
Sophie Çabal Berthoumieu ◽  
Marie Raffin ◽  
Denise Thuilleaux ◽  
Christine Poitou ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Primary Outcome ◽  
Dose Effect ◽  
Secondary Outcome ◽  
Controlled Study ◽  
Prader Willi Syndrome ◽  
Eating Behaviours ◽  
Behavioural Disorders ◽  
Double Blind ◽  
Effect Relationship

Abstract Prader–Willi Syndrome (PWS) is a rare genetic syndrome leading to severe behavioural disorders and mild cognitive impairment. The objective of this double-blind randomised placebo-controlled trial was to study the efficacy and tolerance of topiramate on behavioural disorders in patients with PWS. Participants (aged 12–45 years) had genetically confirmed PWS and severe irritability/impulsivity, eating disorders and/or obesity, and skin picking. Thirty-two participants received a placebo (PBO), and 30 participants received topiramate (TOP) (50–200 mg/day) for 8 weeks. The primary outcome was the rate of responders using the Clinical Global Impression-Improvement (CGI-I) scale. The secondary outcome measures included the Aberrant Behaviour Checklist, the Dykens Hyperphagia Questionnaire (DHK), the Self-Injurious Behaviour Scale (SIBS) and the body mass index (BMI). We found no significant difference in the primary outcome (the CGI-I): 9 (30%) patients were very much or much improved in the TOP group compared to 7 (22.6%) patients in the PBO group. However, the DHK behaviour and severity scores improved significantly more over time in patients treated with topiramate versus those receiving a placebo, with a significant dose–effect relationship. DHK scores were also significantly associated with genetic subtypes and hospitalisation status. The effects of topiramate on eating behaviours remained significant after adjusting for genetic subtype and hospitalisation. Topiramate had therefore a significant effect on eating disorders, with a dose–effect relationship. Given the burden of eating disorders in PWS, we believe that topiramate may become the first psychotropic option within the global care of obesity in individuals with PWS.

Chronobiology and Clinical Activity of Dation 500 mg in Chronic Venous Insufficiency

1994 ◽  
Vol 9 (1_suppl) ◽  
pp. 15-18 ◽  
Author(s):  
G. Menyhei ◽  
G. Acsady ◽  
A. Hetenyi ◽  
D. Dubeaux ◽  
G. Rado
Keyword(s):  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Controlled Trial ◽  
Clinical Signs ◽  
Vascular Diseases ◽  
Clinical Activity ◽  
Therapeutic Activity ◽  
Double Blind ◽  
Drug Administration Schedule ◽  
Group A

Objective: To assess the chronobiological effect on therapeutic activity of Daflon 500 mg and to determine the optimum method of administration. Design: Multicentre, randomized, double-blind, controlled trial. Setting: Hospital outpatient clinics for vascular diseases in Hungary. Patients: Three hundred and twenty ambulatory patients with symptoms of chronic venous insufficiency randomized to three groups. Interventions: Oral administration daily of 1000 mg of Daflon 500 mg for 2 months in three different ways (morning or evening or morning and evening). Main outcome measures: Symptoms and clinical signs of chronic venous insufficiency. Results: In each group, a statistically significant improve ment was observed between the first (DO) and the last visit (D60) concerning all symptoms. Oedema disappeared in a mean percentage of patients ranging between 26% and 43%, according to the group and the side affected ( p <0.001). For the most affected leg, a significant decrease ( p <0.001) of ankle and calf circumferences was observed in each group. The first significant improvement, in comparison to DO, occurred between D15 and D30 for all symptoms and ankle circumference. The comparison between the groups did not disclose any difference concerning the improvement of symptoms and signs. Conclusion: In this study, Daflon 500 mg demonstrated its therapeutic activity in chronic venous insufficiency, irrespective of the daily drug administration schedule.

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