Dose-Effect Relationship of ZnPc-PDT on Tumor Cells In Vitro

2017 ◽  
Vol 44 (3) ◽  
pp. 0307001
Author(s):  
杨 曼 Yang Man ◽  
邢力允 Xing Liyun ◽  
高卫栋 Gao Weidong ◽  
顾月清 Gu Yueqing
Keyword(s):  
Tumor Cells ◽  
Dose Effect ◽  
Effect Relationship ◽  
Relationship Of

Clinical Strategy for Optimal Traditional Chinese Medicine (TCM) Herbal Dose Selection in Disease Therapeutics: Expert Consensus on Classic TCM Herbal Formula Dose Conversion

2015 ◽  
Vol 43 (08) ◽  
pp. 1515-1524 ◽  
Author(s):  
Lin-Hua Zha ◽  
Li-Sha He ◽  
Feng-Mei Lian ◽  
Zhong Zhen ◽  
Hang-Yu Ji ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Measurement System ◽  
Expert Consensus ◽  
Dose Effect ◽  
Herbal Formula ◽  
Dose Selection ◽  
Effect Relationship ◽  
Weight Measurement ◽  
Relationship Of

The clinical therapeutics of traditional Chinese medicine (TCM) constitutes a complicated process which involves theory, diagnosis, and formula prescription with specific herbal dosage. Zhang Zhong-Jing’s classic work, Treatise on Febrile and Miscellaneous Diseases, has been influencing TCM practice for almost 2000 years. However, during this extended period of time in Chinese history, the Chinese weight measurement system experienced noticeable changes. This change in the weight measurement system inevitably, and perhaps even negatively, affected TCM herbal dosage determination and treatment outcome. Thus, in modern society, a full understanding of the accuracy of herbal dose selection has a critical importance in the TCM daily practice of delivering the best treatment to the patients suffering from different illnesses. In the 973 Project of the Chinese National Basic Research Program, expert consensus on classic TCM formula dose conversion has been reached based on extensive literature review and discussion on the dose–effect relationship of classic TCM formulas. One “liang” (两) in classic TCM formulas is equivalent to 13.8[Formula: see text]g. However, based on many TCM basic and clinical studies of variable herbal formula prescriptions and herbal drug preparations, the rule of one liang equals 13.8[Formula: see text]g should be adjusted according to different disease conditions. Recommended by the committee on TCM formula dose–effect relationship of the China Association of Chinese Medicine and the World Federation of Chinese Medicine Societies, the following expert consensus has been reached: (i) One liang converts to 6–9[Formula: see text]g for the severely and critically ill patients. (ii) One liang converts to 3–6[Formula: see text]g for the patients suffering from chronic diseases. (iii) One liang converts to 1–3[Formula: see text]g in preventive medicine. The above conversions should be used as a future TCM practice guideline. Using this recommended guideline should enhance the effectiveness of daily TCM practice.

scholarly journals Characteristics and dose‐effect relationship of clinical gamma‐hydroxybutyrate intoxication: A case series

2021 ◽  
Author(s):  
Madelaine Abid ◽  
Jana Kietzerow ◽  
Stefanie Iwersen‐Bergmann ◽  
Tino Schnitgerhans ◽  
Hilke Andresen‐Streichert
Keyword(s):  
Case Series ◽  
Dose Effect ◽  
Effect Relationship ◽  
Gamma Hydroxybutyrate ◽  
Relationship Of

Dose-effect Relationship of the β-Agonists Fenoterol and Salbutamol in Patients With Asthma

CHEST Journal ◽  
1994 ◽  
Vol 105 (6) ◽  
pp. 1738-1742 ◽  
Author(s):  
Michael T. Newhouse ◽  
Myrna B. Dolovich ◽  
Farouk Kazim
Keyword(s):  
Dose Effect ◽  
Effect Relationship ◽  
Relationship Of

The Dose-effect Relationship of Metocurine

1988 ◽  
Vol 68 (4) ◽  
pp. 604-606 ◽  
Author(s):  
AARON F. KOPMAN
Keyword(s):  
Dose Effect ◽  
Effect Relationship ◽  
Relationship Of

scholarly journals Synergistic Effects of Trimethoprim with Flos Lonicerae on Antibacterial Activity and Dose-Effect Relationship in Vitro

2016 ◽  
Author(s):  
Yizhe Cui ◽  
Qiuju Wang ◽  
Xin Wang
Keyword(s):  
Bactericidal Activity ◽  
Synergistic Effects ◽  
Least Square Method ◽  
Least Square ◽  
Dose Effect ◽  
Plate Count ◽  
Dilution Method ◽  
Effect Relationship ◽  
Flos Lonicerae

Observe the synergistic effect and dose-effect relationship of Trimethoprim (TMP) on bactericidal activity with Flos Lonicerae in vitro. Microamount chessboard dilution method was conducted to determine the minimal inhibitory concentration (MIC) of Trimethoprim, Flos Lonicerae, as well as the combination of Trimethoprim and Flos Lonicerae separately against Staphylococcus aureus, Escherichia coli in vitro and Salmonella. The pour plate count method was used to determine the combined bactericidal activity of Flos Lonicerae combined with Different concentrations TMP. The results showed that the MIC values of the combination of Flos Lonicerae with TMP was much less than the MIC values of the independent use of Flos Lonicerae or TMP, The FIC values of the combination of Flos Lonicerae with TMP were between 0.5 and 1, there was additive effect between them. The bactericidal rates were fitted with least square method, the 95% confidence intervals of the optimal blending quantity about the combination of Flos Lonicerae with TMP on the test organisms were 231μg·mL-1-249μg·mL-1, 237μg·mL-1-259μg·mL-1, and 235 -259μg·mL-1

scholarly journals The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization

2020 ◽  
Vol 71 (2) ◽  
pp. 115-120
Author(s):  
Corina Brandusa ◽  
Bogdan-Ionel Vatu ◽  
Stefana Oana Purcaru ◽  
Stefan-Alexandru Artene ◽  
Sandra Alice Buteica ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Tumor Cells ◽  
Medical Oncology ◽  
Optimal Dose ◽  
Dose Effect ◽  
Treatment Protocols ◽  
Cellular Kinetics ◽  
Action Type

Medical oncology has seen an exponential growth in the last 20 years with the vast majority of malignancies receiving new therapeutic options with substantial benefits to patients� survival and quality of life. Glioblastomas (GBMs), however, have remained largely incurable, with over 90% of patients dying within 5 years of diagnosis. The estimation of a dose�effect type ratio, regarding the action of an oncological drug on tumor cells, leads to relevant conclusions in establishing the optimal medication, specific to the chemotherapeutic act. The identification of the optimal dose of agent is very important, based on experiments on cell lines with regards to cellular kinetics. In this study, we developed a mathematical model based on the specific transfer function of a dose�response action type of a drug on tumor cells in vitro.

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