scholarly journals Linkage analysis of adult height with parent-of-origin effects in the Framingham Heart Study

BMC Genetics ◽  
2003 ◽  
Vol 4 (Suppl 1) ◽  
pp. S76 ◽  
Author(s):  
Nandita Mukhopadhyay ◽  
Daniel E Weeks
Keyword(s):  
Linkage Analysis ◽  
Framingham Heart Study ◽  
Adult Height ◽  
Heart Study ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Genome-Wide Linkage Analysis Assessing Parent-of-Origin Effects in the Inheritance of Type 2 Diabetes and BMI in Pima Indians

Diabetes ◽  
2001 ◽  
Vol 50 (12) ◽  
pp. 2850-2857 ◽  
Author(s):  
R. S. Lindsay ◽  
S. Kobes ◽  
W. C. Knowler ◽  
P. H. Bennett ◽  
R. L. Hanson
Keyword(s):  
Type 2 Diabetes ◽  
Linkage Analysis ◽  
Pima Indians ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Parent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12513 ◽  
Author(s):  
Delphine Fradin ◽  
Keely Cheslack-Postava ◽  
Christine Ladd-Acosta ◽  
Craig Newschaffer ◽  
Aravinda Chakravarti ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Genomewide Linkage Analysis of Body Mass Index across 28 Years of the Framingham Heart Study

2002 ◽  
Vol 71 (5) ◽  
pp. 1044-1050 ◽  
Author(s):  
Larry D. Atwood ◽  
Nancy L. Heard-Costa ◽  
L. Adrienne Cupples ◽  
Cashell E. Jaquish ◽  
Peter W.F. Wilson ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Linkage Analysis ◽  
Body Mass ◽  
Framingham Heart Study ◽  
Heart Study ◽  
Genomewide Linkage ◽  
Genomewide Linkage Analysis

scholarly journals Polygenic Scores and Parental Predictors: An Adult Height Study Based on the United Kingdom Biobank and the Framingham Heart Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Chong You ◽  
Zhenwei Zhou ◽  
Jia Wen ◽  
Yun Li ◽  
Cheng Heng Pang ◽  
...  
Keyword(s):  
United Kingdom ◽  
Framingham Heart Study ◽  
Adult Height ◽  
The United Kingdom ◽  
Heart Study ◽  
Polygenic Scores ◽  
Human Height ◽  
Height Prediction ◽  
Parental Height ◽  
Parental Information

Human height is a polygenic trait, influenced by a large number of genomic loci. In the pre-genomic era, height prediction was based largely on parental height. More recent predictions of human height have made great strides by integrating genotypic data from large biobanks with improved statistical techniques. Nevertheless, recent studies have not leveraged parental height, an added feature that we hypothesized would offer complementary predictive value. In this study, we assessed the predictive power of polygenic risk scores (PRS) combined with the traditional parental height predictors. Our study analyzed genotypic data and parental height from 1,071 trios from the United Kingdom Biobank and 444 trios from the Framingham Heart Study. We explored a series of statistical models to fully evaluate the performance of several PRS constructed together with parental information and proposed a model we call PRS++ that includes gender, parental height, and PRSs of parents and proband. Our estimate of height with an R2 of ∼0.82 is, to our knowledge, the most accurate estimate yet achieved for predicting human adult height. Without parental information, the R2 from the best PRS-driven model is ∼0.73. In summary, using adult height prediction as an example, we demonstrated that traditional predictors still play important roles and merit integration into the current trends of intensive PRS approaches.

scholarly journals Genomewide Linkage Analysis of Weight Change in the Framingham Heart Study

2005 ◽  
Vol 90 (6) ◽  
pp. 3197-3201 ◽  
Author(s):  
Caroline S. Fox ◽  
Nancy L. Heard-Costa ◽  
Ramachandran S. Vasan ◽  
Joanne M. Murabito ◽  
Ralph B. D’Agostino ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Weight Change ◽  
Framingham Heart Study ◽  
Heart Study ◽  
Genomewide Linkage ◽  
Genomewide Linkage Analysis

scholarly journals Assessment of Parent-of-Origin Effects in Linkage Analysis of Quantitative Traits

2001 ◽  
Vol 68 (4) ◽  
pp. 951-962 ◽  
Author(s):  
Robert L. Hanson ◽  
Sayuko Kobes ◽  
Robert S. Lindsay ◽  
William C. Knowler
Keyword(s):  
Linkage Analysis ◽  
Quantitative Traits ◽  
Parent Of Origin ◽  
Origin Effects

Linkage Analysis of Affected Sib Pairs Allowing for Parent‐of‐Origin Effects

2005 ◽  
Vol 69 (1) ◽  
pp. 113-126 ◽  
Author(s):  
Chih‐Chieh Wu ◽  
Sanjay Shete ◽  
Christopher I. Amos
Keyword(s):  
Linkage Analysis ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Affected Sib Pairs ◽  
Sib Pairs

A Genome-Wide Scan for Loci Affecting Normal Adult Height in the Framingham Heart Study

2003 ◽  
Vol 55 (4) ◽  
pp. 191-201 ◽  
Author(s):  
Nandita Mukhopadhyay ◽  
David N. Finegold ◽  
Martin G. Larson ◽  
L. Adrienne Cupples ◽  
Richard H. Myers ◽  
...  
Keyword(s):  
Framingham Heart Study ◽  
Adult Height ◽  
Normal Adult ◽  
Genome Wide ◽  
Heart Study ◽  
A Genome ◽  
Genome Wide Scan
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