scholarly journals Temporal sensitivity of protein kinase A activation in a stochastic reaction-diffusion model of late phase long term potentiation

2009 ◽  
Vol 10 (Suppl 1) ◽  
pp. P202
Author(s):  
Myungsook Kim ◽  
Rodrigo Oliveira ◽  
Wonryull Koh ◽  
Kim Blackwell
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Late Phase ◽  
Reaction Diffusion ◽  
Long Term Potentiation ◽  
Reaction Diffusion Model ◽  
Term Potentiation ◽  
Stochastic Reaction ◽  
Kinase A

scholarly journals Temporal Sensitivity of Protein Kinase A Activation in Late-Phase Long Term Potentiation

2010 ◽  
Vol 6 (2) ◽  
pp. e1000691 ◽  
Author(s):  
MyungSook Kim ◽  
Ted Huang ◽  
Ted Abel ◽  
Kim T. Blackwell
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Late Phase ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Kinase A

scholarly journals Parallel Instabilities of Long-Term Potentiation, Place Cells, and Learning Caused by Decreased Protein Kinase A Activity

2000 ◽  
Vol 20 (21) ◽  
pp. 8096-8102 ◽  
Author(s):  
Alexander Rotenberg ◽  
Ted Abel ◽  
Robert D. Hawkins ◽  
Eric R. Kandel ◽  
Robert U. Muller
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Long Term Potentiation ◽  
Place Cells ◽  
Term Potentiation ◽  
Kinase A

scholarly journals Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.

1994 ◽  
Vol 1 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Y Y Huang ◽  
E R Kandel
Keyword(s):  
Protein Synthesis ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
High Frequency ◽  
Long Term Potentiation ◽  
Dependent Protein Kinase ◽  
Term Potentiation ◽  
Dependent Protein ◽  
Kinase A

To study how the late phase of long-term potentiation (LTP) in hippocampus arises, we examined the resulting LTP for its time course and its dependence on protein synthesis and different second-messenger kinases by applying various conditioning tetani. We find that one high-frequency train (100 Hz) produces a form of LTP that lasts longer than 1 hr but less than 3 hr (the early phase of LTP, or E-LTP). It is blocked by inhibitors of calcium/calmodulin kinase II (Cam kinase II) but is not affected by an inhibitor of cAMP-dependent protein kinase [protein kinase A (PKA) and the protein synthesis inhibitor anisomycin] nor is it occluded by the cAMP activator forskolin. In contrast, when three high-frequency trains are used, the resulting potentiation persists for at least 6-10 hr. The L-LTP induced by three trains differs from the E-LTP in that it requires new protein synthesis, is blocked by an inhibitor of cAMP-dependent protein kinase, and is occluded by forskolin. These results indicate that the two mechanistically distinctive forms of LTP, a transient, early component (E-LTP) and a more enduring form (L-LTP), can be recruited selectively by changing the number of conditioning tetanic trains. Repeated tetani induce a PKA and protein synthesis-dependent late component that adds to the amplitude and duration of the potentiation induced by a single tetanus.

scholarly journals Colocalization of Protein Kinase A with Adenylyl Cyclase Enhances Protein Kinase A Activity during Induction of Long-Lasting Long-Term-Potentiation

2011 ◽  
Vol 7 (6) ◽  
pp. e1002084 ◽  
Author(s):  
Myungsook Kim ◽  
Alan Jung Park ◽  
Robbert Havekes ◽  
Andrew Chay ◽  
Leonardo Antonio Guercio ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Adenylyl Cyclase ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Kinase A

Protein kinase A regulates the long-term potentiation of intrinsic excitability in neonatal trigeminal motoneurons

2013 ◽  
Vol 1541 ◽  
pp. 1-8 ◽  
Author(s):  
Sanam Bakhshishayan ◽  
Akifumi Enomoto ◽  
Tadataka Tsuji ◽  
Susumu Tanaka ◽  
Tadashi Yamanishi ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Long Term Potentiation ◽  
Intrinsic Excitability ◽  
Term Potentiation ◽  
Trigeminal Motoneurons ◽  
Kinase A
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