Toxic optic neuropathy in the setting of docetaxel chemotherapy: a case report

Intrduction. Tacrolimus (fujimycin or FK506) is a potent immunosuppressive drug with growing usage. It is usually used in prevention of transplanted organ rejection. Its use is highly valuable, but like other immunosupressants, it has adverse effects. One of them is optic neuropathy. Case report. A 47-year-old white male patients who had received tacrolimus therapy for nine years, after kidney transplantation, developed a subacute, painless vision loss on both eyes. He was thoroughly examined on different possible optic neuropathies and other causes of vision loss. After exclusion of other possible causes, the diagnosis of toxic optic neuropathy was established. His therapy was converted to cyclosporine, by his nephrologist, but his vision had improved only slightly. Conclusion. Toxic optic neuropathies are presented in everyday ophthalmological practice, but they are underestimated. Diagnosis can be demanding, especially when it comes to drugs and substances whose possible toxic effect on the optic nerve is not widely known. Unlike other adverse effects of tacrolimus therapy on nervous system, optic neuropathy can causes great and permanent functional impairment.

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Ethambutol toxic optic neuropathy: A case report and review

African Vision and Eye Health ◽

10.4102/aveh.v77i1.419 ◽

2018 ◽

Vol 77 (1) ◽

Author(s):

Kevin C. Phillips ◽

Peter C. Clarke-Farr

Keyword(s):

Case Report ◽

Side Effects ◽

Optic Neuropathy ◽

Vision Loss ◽

Early Recognition ◽

Treatment Cessation ◽

Toxic Optic Neuropathy ◽

Vision Restoration

This article presents a case of ethambutol toxic optic neuropathy determined during the routine optometric examination of a 66-year-old man. Ethambutol is an established drug for the treatment of tuberculosis, but has significant side effects, notably optic neuropathy. The prognosis for vision restoration is unpredictable, with the possibility of permanent vision loss. Treatment cessation is the only option to limit ocular damage; therefore, the early recognition of ethambutol optic neuropathy by optometrists is essential.

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Loss of vision secondary to toxic optic neuropathy due to gutka overdose: A Case Report

Journal of Neurology & Stroke ◽

10.15406/jnsk.2021.11.00473 ◽

2021 ◽

Vol 11 (5) ◽

pp. 139-140

Author(s):

Irfan Kabiruddin Jeeva ◽

Sidra Masud ◽

Syed Hasan Raza Abidi, ◽

Tazeen Saeed Ali ◽

Ayesha Akbar Waheed, ◽

...

Keyword(s):

Case Report ◽

Optic Nerve ◽

Optic Neuropathy ◽

Liver Function Tests ◽

Nerve Fibers ◽

Central Scotoma ◽

Case Presentation ◽

Toxic Optic Neuropathy ◽

Oral Form ◽

History Of

Introduction: Toxic optic neuropathy is defined as the damage caused by a toxin to the optic nerve fibers. There is a vast list of toxins that may lead to optic neuropathies. One of the toxins among this list is tobacco. Gutka being an oral form of tobacco, however, has not been previously related to optic neuropathy. Case presentation: We present a case of a 22-year-old male who presented with decreased far vision and gradually increasing photophobia. He had a history of gutka usage, a form of smokeless tobacco. Investigations revealed a central scotoma on FOV, a swollen optic disc on OCT and deranged Liver function tests. A diagnosis of RIGHT + LEFT optic neuropathy secondary to a chemical toxic was made, which in this case, was gutka. Conclusion: Consumption of gutka can lead to irreversible toxic optic neuropathy.

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