scholarly journals Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Linda Penn ◽  
Martin White ◽  
John Oldroyd ◽  
Mark Walker ◽  
K George MM Alberti ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Diabetes Prevention ◽  
Newcastle Upon Tyne

Impaired glucose tolerance: do pharmacological therapies correct the underlying metabolic disturbance?

2003 ◽  
Vol 3 (1_suppl) ◽  
pp. S24-S40 ◽  
Author(s):  
Ralph A Defronzo
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Beta Cell Function ◽  
Diabetes Prevention ◽  
Cell Function ◽  
Pharmacologic Therapy ◽  
Exercise Regimen

Lifestyle intervention prevents or delays the conversion from impaired glucose tolerance (IGT) to type 2 diabetes. However, many subjects fail to achieve and/or maintain long-term weight loss and to follow a regular exercise regimen may require pharmacologic therapy. Insulin resistance in liver, muscle and fat, along with impaired beta-cell function, plays a central role in the pathogenesis of type 2 diabetes. Insulin sensitising drugs, including metformin and the thiazolidinediones, have significantly reduced the conversion rate of IGT to type 2 diabetes in subjects in several large, well designed clinical trials. Insulin-sensitising drugs are likely to play an important role in future strategies for diabetes prevention.

HbA1cin diagnosing and predicting Type 2 diabetes in impaired glucose tolerance: the Finnish Diabetes Prevention Study

2010 ◽  
Vol 28 (1) ◽  
pp. 36-42 ◽  
Author(s):  
P. Pajunen ◽  
M. Peltonen ◽  
J. G. Eriksson ◽  
P. Ilanne-Parikka ◽  
S. Aunola ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Diabetes Prevention ◽  
Prevention Study ◽  
Diabetes Prevention Study

Pre-diabetes: to treat or not to treat?

2003 ◽  
Vol 3 (1_suppl) ◽  
pp. S2-S5
Author(s):  
Ele Ferrannini
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Diabetes Prevention ◽  
Ameliorate Insulin Resistance

The prevalence of diabetes is increasing worldwide, bringing personal and economic burdens. Impaired glucose tolerance (IGT) generally precedes type 2 diabetes and strategies which target IGT and delay or prevent the onset of type 2 diabetes are being explored. IGT and type 2 diabetes are characterised by insulin resistance. Lifestyle and pharmacological approaches which ameliorate insulin resistance are being investigated as methods of diabetes prevention.

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