Bulky DNA adducts in human sperm associated with semen parameters and sperm DNA fragmentation in infertile men: a cross-sectional study

Abstract Background The aim of this study was to provide information on the semen quality pattern of infertile men and age thresholds for semen parameters in China. Methods This was a retrospective cross-sectional study investigating 71,623 infertile men from the Reproductive and Genetic Hospital of CITIC Xiangya in Hunan, China, from 2011 to 2017. The Kruskal-Wallis test, Mann-Kendall test, linear regression model and joinpoint regression were used. Results Although erratic changes were observed in the median semen parameters (sperm concentration 40.1–52.1 × 106/ml, total sperm count 117.8–153.1 × 106, sperm progressive motility 33.4–38.1%) during the 7 years of observation, no significant decrease in semen quality was found, and 47.88% of infertile men showed normal semen parameters according to the World Health Organization (WHO) criteria. According to the joinpoint regression analysis, sperm progressive motility appeared to decrease earlier than the sperm concentration and total sperm count (at 28, 58, and 42 years of age, respectively). Conclusions There is no evidence of a deterioration in semen quality among infertile men in Hunan, China. Semen parameters decreased with increasing age, with turning points noted at different ages. Semen parameters are not absolute evidence for the assessment of male fertility potential. Therefore, we believe that, among semen parameters, the sperm concentration is the best predictor of fertility for ART, followed by motility. Decreased sperm motility may affect natural pregnancy, but it is not necessary for successful IVF.

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Association Between Meat Intake and Semen Parameters Among Iranian Infertile Men: A Cross-sectional Study

10.21203/rs.3.rs-29618/v1 ◽

2020 ◽

Author(s):

Reza Ghiasvand ◽

farahnaz haeri ◽

SeyyedPayam ShariatPanahi ◽

Laleh Dehghan Marvast

Keyword(s):

Semen Quality ◽

Cross Sectional Study ◽

Semen Parameters ◽

Sectional Study ◽

Cross Sectional ◽

Meat Intake ◽

Canned Tuna ◽

Infertile Men ◽

The Relationship ◽

Serving Size

Abstract Objective: Previous studies have proven the effect of dietary patterns on semen quality indicators, but research on the relationship between meat intake and semen quality is limited. Therefore, this study was conducted to investigate the relationship between Meat intake with semen quality.Methods: In this cross sectional study, 400 infertile men were recruited into study during their fertility investigation in Yazd Reproductive Sciences Institute Diagnosed by an andrologist according to the inclusion criteria. Multivariate logistic regression was used to determine the relationship between meat intake and semen parameters. All data were analyzed using SPSS V. 22 software.Results: We found that intake of canned tuna can have two different effects on sperm motility in infertile male. Intake of canned tuna according to the serving size stated in quartile 2, leads to a decrease in the percentage of immotile sperm from 52.93 (CI95%, 51.15-54.71) to 46.55 (CI95%, 44.56-48.54)(Ptrend=0.036). On the other hand, there is an increase in the percentage of immotile sperm from 46.55 (CI95%, 44.56-48.54) to 52.88 (CI95%, 50.94-54.82) in the highest quartile of canned tuna intake.Also, no significant relationship was observed between intake other types of meats and sperm quality indices.Conclusions: We found that intake of canned tuna,base on serving size of quartile 2, is associated with lower percentage of immotile sperm, on the other hand high intake of canned tuna increase percentage of immotile sperm in Iranian infertile men. More extensive studies are recommended in this regard.

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