scholarly journals Extended letrozole regimen versus clomiphene citrate for superovulation in patients with unexplained infertility undergoing intrauterine insemination: A randomized controlled trial

2011 ◽  
Vol 9 (1) ◽  
pp. 84 ◽  
Author(s):  
Usama M Fouda ◽  
Ahmed M Sayed
Keyword(s):  
Randomized Controlled Trial ◽  
Intrauterine Insemination ◽  
Controlled Trial ◽  
Clomiphene Citrate ◽  
Unexplained Infertility ◽  
Randomized Controlled

scholarly journals Comparison of intrauterine insemination and timed intercourse following controlled ovarian hyperstimulation in unexplained infertility: a randomized controlled trial

2019 ◽  
Vol 8 (3) ◽  
pp. 1035
Author(s):  
Sayanti Paul ◽  
Saumen Mandal ◽  
Arghya Pal ◽  
Sumit Ranjan Pramanik
Keyword(s):  
Randomized Controlled Trial ◽  
Intrauterine Insemination ◽  
Controlled Trial ◽  
Controlled Ovarian Hyperstimulation ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
Ovarian Hyperstimulation ◽  
Randomized Controlled ◽  
Group 2 ◽  
Group 1

Background: Being a diagnosis of exclusion the treatment options of unexplained infertility are often empiric. There is significant dilemma regarding the superiority of one over another. Despite increasing use of intrauterine insemination (IUI) in adjunct to controlled ovarian hyperstimulation (COH) there is scarcity of randomized controlled trials (RCT) from developing countries. Objective was to compare IUI and timed intercourse (TI) in super ovulated cycles among couples with unexplained infertility over one year.Methods: In this prospective randomized controlled trial total 85 patients were randomly assigned into group 1 (COH with IUI, N= 44) and group 2 (COH with TI, N=41). Patients underwent COH using sequential Clomiphene Citrate and injection human menopausal gonadotrophin followed by IUI in group 1 and timed intercourse in group 2. Either protocol was repeated for three consecutive cycles. Finally, both groups were compared for clinical pregnancy rate, adverse effects and acceptability of the treatment process and outcome. Comparison was done by Student’s unpaired t test for continuous and 2-tailed chi square test for categorical variables.Results: Clinical pregnancy rates following COH/IUI and COH/TI were 13.64% and 19.51% respectively. There was observable difference in the acceptability of the outcome (38.64% in IUI and 56.09% in TI group). All the results including complications and side effect rates were statistically insignificant.Conclusions: Present study failed to show any improvement of pregnancy rates following addition of IUI over TI and it raised the probability that the outcome of the procedure may not be well accepted.

scholarly journals Effect of Hydrotubation in Unexplained Infertility – A Randomized Controlled Trial

2016 ◽  
Vol 22 (3) ◽  
Author(s):  
Shazia Saaqib ◽  
Muhammad Arshad Chohan ◽  
Misbah Ashraf ◽  
Ammara Mumtaz
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Clomiphene Citrate ◽  
Unexplained Infertility ◽  
Control Group ◽  
Fallopian Tubes ◽  
Randomized Controlled ◽  
Tubal Blockage ◽  
Study Participants ◽  
And Control

<p>Unexplained infertility is a major gynecological problem with complex etiolgy. Partial tubal blockage with inflammatory reaction and thick mucus plugs in fallopian tubes and cervix is one of the likely causes in such cases. This study is based on the hypothesis that women having unexplained infertility could be helped by transcervical flushing of fluid through the fallopian tubes which would remove reversible blocking factors and help in achieving pregnancy.</p><p><strong>Objective:</strong><strong>  </strong>To compare the outcome of hydrotubation<br /> in unexplained infertility in clomiphene citrate stimulated cycles with control group (no Hydrotubation).</p><p><strong>Setting:</strong><strong>  </strong>Infertility Centre of a Public Sector Hospital.</p><p><strong>Study Design:</strong><strong>  </strong>A two years Prospective randomized controlled trial from Jan 2014 to Dec 2015.</p><p><strong>Method:</strong><strong>  </strong>128 women participated in the study. Participants were divided into study and control group with 64 members in each group. Ovulation induction was done with clomiphene citrate in all the participants and confirmed by ovulation detection strips and follicular tracking on Ultrasonography. 50 cc cocktail of inject-ion (inj.) kanamycin 1 gm, inj. hydrocortisone and normal saline was injected transcervically in study group for three consecutive days from the next day after end of menstruation. No hydrotubation was done in control group. Main outcome measures were number of conceptions within next 3 cycles and complications of hydrotubation.</p><p><strong>Results:</strong><strong>  </strong>In hydrotubation group, 20 women conceived. Out of these, 14 women conceived in the same cycle in which hydrotubation was done while 6 pregnancies occurred in subsequent cycle. 4 pregnancies occurred in the control group. Complications of hydrotubation were mild abdominal pain (59 women), vomiting (49 women) and Per vaginum bleeding (18 women). There were significantly more pregnancies in women who experienced right shoulder tip pain after the procedure.</p><p><strong>Conclusion:</strong><strong>  </strong>In women with unexplained infertility, tubal hydration can increase conception rate and decrease the time to achieve pregnancy.</p><p> </p>

Effect of Metformin on Chemical Pregnancy Rate in women with Unexplained Infertility (A randomized controlled trial)

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hisham M Fathy ◽  
Ahmed M BahaaEldin ◽  
Sarah Safwat ◽  
Elham R Mohammed
Keyword(s):  
Randomized Controlled Trial ◽  
Pregnancy Rate ◽  
Ovulation Induction ◽  
Controlled Trial ◽  
Clomiphene Citrate ◽  
Maternity Hospital ◽  
Unexplained Infertility ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Infertility Patients

Abstract Background There is controversy regarding treatment of unexplained infertility due to absence of specific pathophysiological rational which allows curative intervention. The main three lines of treatment of such cases are confrolled ovarian hyperstimulation, IUI with spontaneous or induced ovulation and third is IVF. Aim of the Work to evaluate the effect of metformin on chemical pregnancy rate in women with unexplained infertility. Patients and Methods: This was a prospective randomized controlled trial study which was conducted on 170 women with unexplained infertility in Ain Shams Maternity Hospital. Results :. Incidence of chemical pregnancy was not statistically sigfificantly different between both groups (PR: 18.8% vs.16.5% P 0.84) in metfonnin and clomiphene y•oup respectively. (NNT) was estimated to be 42.5. Conclusion our study showed little benefit was added to the patients by using metfonnin as adjuvant therapy to clomiphene citrate during ovulation induction as regards chemical pregnancy. 42 women are needed to be freated with metformin to get one more pregnant woman by pregnancy test

Sign in / Sign up

Export Citation Format

Share Document