scholarly journals Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations

2014 ◽  
Vol 9 (1) ◽  
pp. 642 ◽  
Author(s):  
Meiling Ye ◽  
Ling Tang ◽  
Mengjun Luo ◽  
Jing Zhou ◽  
Bin Guo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cytochrome P450 ◽  
Time Dependent ◽  
Metabolic Activities ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes ◽  
Hepatic Cytochrome

Efavirenz-induced neurological symptoms in rare homozygote CYP2B6 *2/*2 (C64T)

2007 ◽  
Vol 18 (8) ◽  
pp. 575-576 ◽  
Author(s):  
Osamu Usami ◽  
Yugo Ashino ◽  
Yuichi Komaki ◽  
Masafumi Tomaki ◽  
Toshiya Irokawa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytochrome P450 ◽  
Plasma Concentrations ◽  
Highly Active ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes ◽  
Hiv 1 ◽  
Rare Homozygote ◽  
Hepatic Cytochrome

Some of the HIV-1-infected patients who were given highly active anti-retroviral therapy (HAART) including efavirenz (EFV) presented adverse central nervous system (CNS) symptoms such as fatigue and insomnia. The incidence of adverse CNS symptoms is associated with hepatic cytochrome P450 isozymes (CYP2B6) polymorphisms. For example, CYP2B6 *6 (G516T and A785G) and *7 (G516T, A785G and C1459T) prolonged the EFV half-life despite discontinuation of EFV. CYP2B6 *2/*2 (C64T) is extremely rare and there have been no data describing the EFV plasma concentrations in C64T homozygous patients, who developed adverse CNS symptoms. C64T homozygous possibly has some catalytic defects.

Effect of exposure to four organic solvents on hepatic cytochrome P450 isozymes in rat

1996 ◽  
Vol 99 (1-3) ◽  
pp. 239-252 ◽  
Author(s):  
Rui-Sheng Wang ◽  
Tamie Nakajima ◽  
Hiroshi Tsuruta ◽  
Takeshi Honma
Keyword(s):  
Cytochrome P450 ◽  
Organic Solvents ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes ◽  
Hepatic Cytochrome
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