Induction of hepatic cytochrome P450 isozymes, benzo(a)pyrene metabolism and DNA binding following exposure to polycyclic aromatic hydrocarbon residues generated during repeated fish fried oil in rats

2006 ◽  
Vol 213 (2) ◽  
pp. 126-134 ◽  
Author(s):  
Manoj K. Pandey ◽  
Sanjay Yadav ◽  
Devendra Parmar ◽  
Mukul Das
Keyword(s):  
Cytochrome P450 ◽  
Dna Binding ◽  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Polycyclic Aromatic ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes ◽  
Fried Oil ◽  
Hepatic Cytochrome

Efavirenz-induced neurological symptoms in rare homozygote CYP2B6 *2/*2 (C64T)

2007 ◽  
Vol 18 (8) ◽  
pp. 575-576 ◽  
Author(s):  
Osamu Usami ◽  
Yugo Ashino ◽  
Yuichi Komaki ◽  
Masafumi Tomaki ◽  
Toshiya Irokawa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytochrome P450 ◽  
Plasma Concentrations ◽  
Highly Active ◽  
P450 Isozymes ◽  
Cytochrome P450 Isozymes ◽  
Hiv 1 ◽  
Rare Homozygote ◽  
Hepatic Cytochrome

Some of the HIV-1-infected patients who were given highly active anti-retroviral therapy (HAART) including efavirenz (EFV) presented adverse central nervous system (CNS) symptoms such as fatigue and insomnia. The incidence of adverse CNS symptoms is associated with hepatic cytochrome P450 isozymes (CYP2B6) polymorphisms. For example, CYP2B6 *6 (G516T and A785G) and *7 (G516T, A785G and C1459T) prolonged the EFV half-life despite discontinuation of EFV. CYP2B6 *2/*2 (C64T) is extremely rare and there have been no data describing the EFV plasma concentrations in C64T homozygous patients, who developed adverse CNS symptoms. C64T homozygous possibly has some catalytic defects.

scholarly journals Mechanistic Role of Cytochrome P450 (CYP) 1 Enzymes in Polycyclic Aromatic Hydrocarbon (PAH)‐Mediated Carcinogenesis

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Bhagavatula Moorthy ◽  
Grady Gastelum ◽  
Alex Veith ◽  
Lihua Wang ◽  
Guodong Zhou ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Polycyclic Aromatic
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