scholarly journals Genetic Evidence for an Essential Role of Neuronally Expressed IL-6 Signal Transducer gp130 in the Induction and Maintenance of Experimentally Induced Mechanical Hypersensitivityin vivoandin vitro

2011 ◽  
Vol 7 ◽  
pp. 1744-8069-7-73 ◽  
Author(s):  
Serena Quarta ◽  
Christian Vogl ◽  
Cristina E Constantin ◽  
Nurcan Üçeyler ◽  
Claudia Sommer ◽  
...  
Keyword(s):  
Essential Role ◽  
Genetic Evidence ◽  
Signal Transducer ◽  
Experimentally Induced

scholarly journals Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum

2008 ◽  
Vol 161 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Kamal El Bissati ◽  
Megan J. Downie ◽  
Seong-Kyoun Kim ◽  
Michael Horowitz ◽  
Nicola Carter ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Essential Role ◽  
Genetic Evidence

scholarly journals Regulation of TGF-β signalling by protein phosphatases

2010 ◽  
Vol 430 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Ting Liu ◽  
Xin-Hua Feng
Keyword(s):  
Growth Factor ◽  
Essential Role ◽  
Transforming Growth Factor ◽  
Protein Phosphatases ◽  
Transforming Growth Factor Β ◽  
Signalling Pathways ◽  
Signal Transducer ◽  
Cellular Functions ◽  
Phosphorylation Cascade

Tight regulation of TGF-β (transforming growth factor-β) superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-β superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-β signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-β signalling and the essential role of protein phosphatases in this process.

scholarly journals Genetic evidence for an essential role of brassinosteroids in plant development

1996 ◽  
Vol 9 (5) ◽  
pp. 701-713 ◽  
Author(s):  
Annette Kauschmann ◽  
Alison Jessop ◽  
Csaba Koncz ◽  
Miklos Szekeres ◽  
Lotbar Willmitzer ◽  
...  
Keyword(s):  
Plant Development ◽  
Essential Role ◽  
Genetic Evidence

Experimental Amyloidosis Induced by Immune Complex

1971 ◽  
Vol 29 ◽  
pp. 582-583
Author(s):  
A. Kawaoi
Keyword(s):  
Immune Complex ◽  
Systemic Amyloidosis ◽  
Human Diseases ◽  
Experimental Amyloidosis ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Immunological Approach ◽  
Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

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