scholarly journals Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: The POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial

Trials ◽  
2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Stefan Klingberg ◽  
Andreas Wittorf ◽  
Christoph Meisner ◽  
Wolfgang Wölwer ◽  
Georg Wiedemann ◽  
...  
Keyword(s):  
Psychotic Disorders ◽  
Supportive Therapy ◽  
Behavioural Therapy ◽  
Controlled Clinical Trial ◽  
Positive Symptoms ◽  
Positive Study ◽  
Cognitive Behavioural ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled ◽  
Single Blind

scholarly journals The effect of flexible cognitive–behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial

2016 ◽  
Vol 208 (3) ◽  
pp. 252-259 ◽  
Author(s):  
Caecilie Böck Buhmann ◽  
Merete Nordentoft ◽  
Morten Ekstroem ◽  
Jessica Carlsson ◽  
Erik Lykke Mortensen
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Behavioural Therapy ◽  
Controlled Clinical Trial ◽  
Post Traumatic Stress ◽  
Cognitive Behavioural ◽  
Randomised Controlled Clinical Trial ◽  
Post Traumatic ◽  
Randomised Controlled

BackgroundLittle evidence exists on the treatment of traumatised refugees.AimsTo estimate treatment effects of flexible cognitive–behavioural therapy (CBT) and antidepressants (sertraline and mianserin) in traumatised refugees.MethodRandomised controlled clinical trial with 2×2 factorial design (registered with Clinicaltrials.gov, NCT00917397, EUDRACT no. 2008-006714-15). Participants were refugees with war-related traumatic experiences, post-traumatic stress disorder (PTSD) and without psychotic disorder. Treatment was weekly sessions with a physician and/or psychologist over 6 months.ResultsA total of 217 of 280 patients completed treatment (78%). There was no effect on PTSD symptoms, no effect of psychotherapy and no interaction between psychotherapy and medicine. A small but significant effect of treatment with antidepressants was found on depression.ConclusionsIn a pragmatic clinical setting, there was no effect of flexible CBT and antidepressants on PTSD, and there was a small-to-moderate effect of antidepressants and psychoeducation on depression in traumatised refugees.

scholarly journals Cognitive-behavioural therapy and family intervention for relapse prevention and symptom reduction in psychosis: Randomised controlled trial

2008 ◽  
Vol 192 (6) ◽  
pp. 412-423 ◽  
Author(s):  
Philippa A. Garety ◽  
David G. Fowler ◽  
Daniel Freeman ◽  
Paul Bebbington ◽  
Graham Dunn ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Relapse Prevention ◽  
Controlled Trial ◽  
Family Intervention ◽  
Behavioural Therapy ◽  
Positive Symptoms ◽  
Treatment As Usual ◽  
Cognitive Behavioural ◽  
Randomised Controlled ◽  
Relapse Rates

BackgroundFamily intervention reduces relapse rates in psychosis. Cognitive-behavioural therapy (CBT) improves positive symptoms but effects on relapse rates are not established.AimsTo test the effectiveness of CBT and family intervention in reducing relapse, and in improving symptoms and functioning in patients who had recently relapsed with non-affective psychosis.MethodA multicentre randomised controlled trial (ISRCTN83557988) with two pathways: those without carers were allocated to treatment as usual or CBT plus treatment as usual, those with carers to treatment as usual, CBT plus treatment as usual or family intervention plus treatment as usual. The CBT and family intervention were focused on relapse prevention for 20 sessions over 9 months.ResultsA total of 301 patients and 83 carers participated. Primary outcome data were available on 96% of the total sample. The CBT and family intervention had no effects on rates of remission and relapse or on days in hospital at 12 or 24 months. For secondary outcomes, CBT showed a beneficial effect on depression at 24 months and there were no effects for family intervention. In people with carers, CBT significantly improved delusional distress and social functioning. Therapy did not change key psychological processes.ConclusionsGeneric CBT for psychosis is not indicated for routine relapse prevention in people recovering from a recent relapse of psychosis and should currently be reserved for those with distressing medication-unresponsive positive symptoms. Any CBT targeted at this acute population requires development. The lack of effect of family intervention on relapse may be attributable to the low overall relapse rate in those with carers.

scholarly journals Cognitive–behavioural therapy for patients with schizophrenia: a multicentre randomized controlled trial in Beijing, China

2014 ◽  
Vol 45 (9) ◽  
pp. 1893-1905 ◽  
Author(s):  
Z.-J. Li ◽  
Z.-H. Guo ◽  
N. Wang ◽  
Z.-Y. Xu ◽  
Y. Qu ◽  
...  
Keyword(s):  
Social Functioning ◽  
Cognitive Behavioural Therapy ◽  
Controlled Trial ◽  
Supportive Therapy ◽  
Behavioural Therapy ◽  
Size Analysis ◽  
Positive Symptoms ◽  
Good Reliability ◽  
Randomized Controlled ◽  
Cognitive Behavioural

BackgroundMeta-analyses support the efficacy of cognitive–behavioural therapy (CBT) for schizophrenia in western cultures. This study aimed to compare the efficacy of CBT and supportive therapy (ST) for patients with schizophrenia in China.MethodA multicentre randomized controlled, single-blinded, parallel-group trial enrolled a sample of 192 patients with schizophrenia. All patients were offered 15 sessions of either CBT or ST over 24 weeks and followed up for an additional 60 weeks. All measures used were standardized instruments with good reliability and validity. The Positive and Negative Syndrome Scale (PANSS) was used to assess symptoms of schizophrenia. The Schedule for Assessing Insight (SAI) was used to assess patients’ insight and the Personal and Social Performance Scale (PSP) was used to assess their social functioning.ResultsEffect-size analysis showed that patients made rapid improvements in all symptoms, insight and social functioning as measured by the PANSS, SAI and PSP at 12 and 24 weeks and maintained these improvements over the course of the study to 84 weeks. Patients in the CBT group showed significantly greater and more durable improvement in PANSS total score (p = 0.045, between-group d = 0.48), positive symptoms (p = 0.018, between-group d = 0.42) and social functioning (p = 0.037, between-group d = 0.64), with significant differences emerging after completion of therapy.ConclusionsBoth CBT and ST combined with medication had benefits on psychopathology, insight and social functioning of patients with schizophrenia. CBT was significantly more effective than ST on overall, positive symptoms and social functioning of patients with schizophrenia in the long term.

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