scholarly journals High-capacity assay to quantify the clonal heterogeneity in potency of mesenchymal stem cells

2011 ◽  
Vol 5 (S8) ◽  
Author(s):  
Kim C O’Connor ◽  
Katie C Russell ◽  
Donald G Phinney ◽  
Michelle R Lacey ◽  
Bonnie L Barrilleaux ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
High Capacity ◽  
Clonal Heterogeneity

In Vitro High-Capacity Assay to Quantify the Clonal Heterogeneity in Trilineage Potential of Mesenchymal Stem Cells Reveals a Complex Hierarchy of Lineage Commitment

Stem Cells ◽  
2010 ◽  
Vol 28 (4) ◽  
pp. 788-798 ◽  
Author(s):  
Katie C. Russell ◽  
Donald G. Phinney ◽  
Michelle R. Lacey ◽  
Bonnie L. Barrilleaux ◽  
Kristin E. Meyertholen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
High Capacity ◽  
Lineage Commitment ◽  
Clonal Heterogeneity

Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to be Aware of.

2020 ◽  
Vol 21 ◽  
Author(s):  
Mohammad Saeedi ◽  
Muhammad Sadeqi Nezhad ◽  
Fatemeh Mehranfar ◽  
Mahdieh Golpour ◽  
Mohammad Ali Esakandari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Cells ◽  
Immune Modulation ◽  
Adult Stem Cells ◽  
Inflammatory Diseases ◽  
High Capacity ◽  
Genetically Engineered ◽  
Cartilage Cells ◽  
Biological Aspects

: Mesenchymal stem cells (MSCs), a form of adult stem cells, are known to have a self-renewing property and the potential to specialize into a multitude of cells and tissues such as adipocytes, cartilage cells, and fibroblasts. MSCs can migrate and home to the desired target zone where inflammation is present. The unique characteristics of MSCs in repairing, differentiation, regeneration, and its high capacity of immune modulation has attracted tremendous attention for exerting them in clinical purposes, as they contribute to tissue regeneration process and anti-tumor activity. The MSCs-based treatment has demonstrated remarkable applicability towards various diseases such as heart and bone malignancies, and cancer cells. Importantly, genetically engineered MSCs, as a state-of-the-art therapeutic approach, could address some clinical hurdles by systemic secretion of cytokines and other agents with a short half-life and high toxicity. Therefore, understanding the biological aspects and the characteristics of MSCs is an imperative issue of concern. Herein, we provide an overview of the therapeutic application and the biological features of MSCs against different inflammatory diseases and cancer cells. We further shed light on MSCs physiological interaction, such as migration, homing, and tissue repairing mechanisms with different healthy and inflamed tissues.

scholarly journals Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells

2002 ◽  
Vol 295 (2) ◽  
pp. 354-361 ◽  
Author(s):  
Takeshi Okamoto ◽  
Tomoki Aoyama ◽  
Tomitaka Nakayama ◽  
Takeharu Nakamata ◽  
Taisuke Hosaka ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Clonal Heterogeneity ◽  
Differentiation Potential

scholarly journals Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

2020 ◽  
Author(s):  
Sahar Esfandyari ◽  
Rishi Man Chugh ◽  
Hang-Soo Park ◽  
Elie Hobeika ◽  
Mara Ulin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Medical Condition ◽  
Polycystic Ovary ◽  
High Capacity ◽  
Female Infertility ◽  
Great Promise ◽  
Cell Based Therapy ◽  
Therapeutic Outcomes ◽  
Cell Sources

Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency and to improve reproductive health for a significant number of women worldwide.

scholarly journals Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2253
Author(s):  
Sahar Esfandyari ◽  
Rishi Man Chugh ◽  
Hang-soo Park ◽  
Elie Hobeika ◽  
Mara Ulin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Medical Condition ◽  
Polycystic Ovary ◽  
High Capacity ◽  
Female Infertility ◽  
Great Promise ◽  
Cell Based Therapy ◽  
Therapeutic Outcomes ◽  
Cell Sources

Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.

scholarly journals High capacity of purified mesenchymal stem cells for cartilage regeneration

2015 ◽  
Vol 35 (2) ◽  
pp. 078-085 ◽  
Author(s):  
Eriko Grace Suto ◽  
Yo Mabuchi ◽  
Nobuharu Suzuki ◽  
Asuka Koyanagi ◽  
Yoshiko Kawabata ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
High Capacity ◽  
Cartilage Regeneration

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

1417: Mesenchymal Stem Cells Alone or Modified with ENOS Restore Erectile Function in the Aged Rat: Cell-Based Gene Therapy for Erectile Dysfunction

2004 ◽  
Vol 171 (4S) ◽  
pp. 373-373
Author(s):  
Trinity J. Bivalacqua ◽  
Mustafa F. Usta ◽  
Hunter C. Champion ◽  
Weiwen Deng ◽  
Philip J. Kadowitz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Mesenchymal Stem Cells ◽  
Erectile Dysfunction ◽  
Erectile Function ◽  
Aged Rat

Placenta mesenchymal stem cells on a chorion scaffold as a potential osteogenic graft for peripartal bone regeneration

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
S Mohr ◽  
BC Portmann-Lanz ◽  
A Schoeberlein ◽  
R Sager ◽  
DV Surbek
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration
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