scholarly journals Process development and optimization of fed-batch production processes for therapeutic proteins by CHO cells

2013 ◽  
Vol 7 (S6) ◽  
Author(s):  
Marie-Françoise Clincke ◽  
Mareike Harmsen ◽  
Laetitia Malphettes
2011 ◽  
Vol 5 (S8) ◽  
Author(s):  
Nadine Kochanowski ◽  
Gaetan Siriez ◽  
Sarah Roosens ◽  
Laetitia Malphettes

Energies ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3659
Author(s):  
Andrzej Szajna ◽  
Mariusz Kostrzewski ◽  
Krzysztof Ciebiera ◽  
Roman Stryjski ◽  
Waldemar Woźniak

Industry 4.0, a term invented by Wolfgang Wahlster in Germany, is celebrating its 10th anniversary in 2021. Still, the digitalization of the production environment is one of the hottest topics in the computer science departments at universities and companies. Optimization of production processes or redefinition of the production concepts is meaningful in light of the current industrial and research agendas. Both the mentioned optimization and redefinition are considered in numerous subtopics and technologies. One of the most significant topics in these areas is the newest findings and applications of artificial intelligence (AI)—machine learning (ML) and deep convolutional neural networks (DCNNs). The authors invented a method and device that supports the wiring assembly in the control cabinet production process, namely, the Wire Label Reader (WLR) industrial system. The implementation of this device was a big technical challenge. It required very advanced IT technologies, ML, image recognition, and DCNN as well. This paper focuses on an in-depth description of the underlying methodology of this device, its construction, and foremostly, the assembly industrial processes, through which this device is implemented. It was significant for the authors to validate the usability of the device within mentioned production processes and to express both advantages and challenges connected to such assembly process development. The authors noted that in-depth studies connected to the effects of AI applications in the presented area are sparse. Further, the idea of the WLR device is presented while also including results of DCNN training (with recognition results of 99.7% although challenging conditions), the device implementation in the wire assembly production process, and its users’ opinions. The authors have analyzed how the WLR affects assembly process time and energy consumption, and accordingly, the advantages and challenges of the device. Among the most impressive results of the WLR implementation in the assembly process one can be mentioned—the device ensures significant process time reduction regardless of the number of characters printed on a wire.


2019 ◽  
Vol 23 (06) ◽  
pp. 1950054
Author(s):  
ABEL DUARTE ALONSO ◽  
SENG K. KOK ◽  
SEAMUS O'BRIEN

By drawing from the dynamic capabilities approach, this study examines innovation from the perspective of winery owners and managers representing four different countries. Semi-structured, face-to-face interviews were conducted with 56 participants. As many as 12 common forms of innovation were revealed among the four groups, with intangible aspects conforming the large majority. For instance, sensing comprised efforts to increase export markets, new winery equipment and technologies, whereas seizing included more presence in social media and wine tourism, focusing on niche-batch production, or preserving and rescuing ancient varietals. Reconfiguring was manifested through consistency in product quality, more knowledge of foreign languages, networking and by trying new ways, particularly in production processes. A resulting theoretical framework, which reveals a circular process among sensing, seizing and reconfiguring, is subsequently proposed. Similarly, a developed roadmap aligned with wineries’ way of innovating suggests important implications for wineries and their industry.


2016 ◽  
Vol 113 (9) ◽  
pp. 1942-1952 ◽  
Author(s):  
Duncan McVey ◽  
Michael Aronov ◽  
Giovanni Rizzi ◽  
Alexis Cowan ◽  
Charo Scott ◽  
...  
Keyword(s):  

2008 ◽  
Vol 79 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Dheepak Maharajh ◽  
Robyn Roth ◽  
Rajesh Lalloo ◽  
Clinton Simpson ◽  
Robin Mitra ◽  
...  

2007 ◽  
Vol 96 (6) ◽  
pp. 1127-1138 ◽  
Author(s):  
Gian M. Oddone ◽  
Christopher Q. Lan ◽  
Helen Rawsthorne ◽  
David A. Mills ◽  
David E. Block

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