scholarly journals A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

2008 ◽  
Vol 1 (1) ◽  
Author(s):  
Richard Abraham ◽  
Valentina Moskvina ◽  
Rebecca Sims ◽  
Paul Hollingworth ◽  
Angharad Morgan ◽  
...  
2008 ◽  
Vol 4 ◽  
pp. T578-T578 ◽  
Author(s):  
Richard Abraham ◽  
Lyudmila Georgieva ◽  
Rebecca Sims ◽  
Angharad Morgan ◽  
Paul Hollingworth ◽  
...  

2015 ◽  
Vol 25 (4) ◽  
pp. 139-146 ◽  
Author(s):  
Atsushi Hirano ◽  
Tomoyuki Ohara ◽  
Atsushi Takahashi ◽  
Masayuki Aoki ◽  
Yuta Fuyuno ◽  
...  

2021 ◽  
pp. 1-10
Author(s):  
Sarang Kang ◽  
Jungsoo Gim ◽  
Jiwoon Lee ◽  
Tamil Iniyan Gunasekaran ◽  
Kyu Yeong Choi ◽  
...  

The present study reports two novel genome-wide significant loci for late-onset Alzheimer’s disease (LOAD) identified from APOE ε4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer’s disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer’ and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.


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