scholarly journals Molecular characterization and ligand binding specificity of the PDZ domain-containing protein GIPC3 from Schistosoma japonicum

2012 ◽  
Vol 5 (1) ◽  
pp. 227 ◽  
Author(s):  
Yi Mu ◽  
Haiming Huang ◽  
Shuai Liu ◽  
Pengfei Cai ◽  
Youhe Gao
Keyword(s):  
Ligand Binding ◽  
Schistosoma Japonicum ◽  
Molecular Characterization ◽  
Pdz Domain ◽  
Binding Specificity

scholarly journals Conformational Dynamics and Structure Underlie the Novel Ligand Binding Specificity of a Tiam1 PDZ Domain Mutant

2016 ◽  
Vol 110 (3) ◽  
pp. 514a
Author(s):  
Ernesto J. Fuentes ◽  
Xu Liu ◽  
David C. Speckhard ◽  
Tyson R. Shepherd ◽  
Sarah R. Hengel ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Conformational Dynamics ◽  
Pdz Domain ◽  
Binding Specificity ◽  
The Novel

scholarly journals Structural and Dynamic Features Underlie the Switch of Ligand Binding Specificity in a Tiam1 PDZ Domain Mutant

2014 ◽  
Vol 106 (2) ◽  
pp. 661a
Author(s):  
Ernesto J. Fuentes ◽  
Xu Liu ◽  
David C. Speckhard ◽  
Tyson R. Shepherd
Keyword(s):  
Ligand Binding ◽  
Pdz Domain ◽  
Binding Specificity ◽  
Dynamic Features

Mechanism of ligand binding – PDZ domain taken as example

2017 ◽  
Vol 13 (4) ◽  
Author(s):  
Dawid Dułak ◽  
Mateusz Banach ◽  
Zdzisław Wiśniowski ◽  
Leszek Konieczny ◽  
Irena Roterman
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Ion Channel ◽  
Pdz Domain ◽  
Traditional Model ◽  
Beta Sheet ◽  
Hydrophobic Core ◽  
Beta Strand ◽  
Model Based ◽  
Specific Ligand

AbstractThe mechanism of specific ligand binding by proteins is discussed using the PDZ domain complexing the pentapeptide. This process is critical for clustering the membrane ion channel. The traditional model based on the Beta-sheet extension by complexed pentapeptide is interpreted as a hydrophobic core extension supported by additional Beta-strand generated by complexed pentapeptide. The explanation is based on the fuzzy oil drop model applied to the crystal structure of PDZ-pentapeptide.

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