C-reactive protein levels: a prognostic marker for patients with head and neck cancer?

e17034 Background: High-sensitivity C-reactive protein (hsCRP) an acute phase inflamatory reactant protein, has been used to predict the risk of cardiovascular disease healthy individuals and to monitor treatment responses. Epidemiological evidence also points to link between inflammation and development of cancer, i.e. long-term inflammation and dysplasia. Worldwide ~ 15 % of the cancer incidence is associated with microbial infection. NSAIDs have been used for cancer preventionin familial adenomatous polyposis. The objective of study is to evaluate the association between hs-CRP and head and neck cancer (SCCHN). Methods: Prospective, cross sectional case-control study was under taken involving 36 SCCHN (cases) and 36 normal volunteers age matched (controls). Cases staged as per UICC TNM. The study subjects 4ml clotted blood, centrifuged, serum stored at -20°C. hsCRP (mg/L) determined using Quantitative Immunoturbidimetric method. Statistical analysis was performed using SPSS. Results: Evaluable subjects = 72, Cases (Cancer patients) = 36 & Control = 36. Age group range 18 to 80 yrs. Mean Age Cases 59.5+9.9 v/s Control 59+96. M: F Cases- 25:9 v/s Control 27:9. In Cases Oral Ca – 22(61.1%) & Oropharynx - 14 (38.9%).T4 – 20(55.6%), T3-8(22.2%) & T2-8(22.2%). N3-3(8.3%), N2-14(38.9%), N1-5(13.9%) & N0-14(38.9%). The hsCRP of Control group v/s Cancer Case group = 3.03 ± 2.61 v/s19.23 ± 19.003 respectively (P < 0.0001). hsCRP for Oral Cancer – 15.07+7.66 & OPX – 25.77+28.31. In the case group, the mean hsCRP levels with tumor size T2 was 119.36 ± 7.0, T3 was 21.32 ± 23.27 , T4 was 18.3350 ± 21.0915 and with Node size N0- 20.3 ± 35.07, N1- 13.8 ± 5.37, N2 -21.6 ± 25.022, N3 - 122.1 ± 1.7. Conclusions: Inflammatory responses play decisive roles at different stages of tumor development, initiation, promotion, malignant conversion, invasion, and metastasis. This study shows serum hsCRP levels were significantly elevated in SCCHN cases compared to age matched normal control subjects. hsCRP Can be used as a surrogate marker of SCCHN. Measuring and charting hsCRP values can prove useful in determining disease progress or the effectiveness of treatments, Furthers studies are contemplated.

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Correlation between Zinc Intake and Zinc Serum Levels with C-reactive Protein Level in Head and Neck Cancer Patients

World Nutrition Journal ◽

10.25220/wnj.v02.i2.0003 ◽

2019 ◽

Vol 2 (2) ◽

pp. 9

Author(s):

Muningtya Philiyanisa Alam ◽

Diana Sunardi ◽

Ikhwan Rinaldi

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Nasopharyngeal Cancer ◽

Serum Zinc ◽

C Reactive Protein ◽

Cross Sectional ◽

Zinc Intake ◽

Reactive Protein

The inflammatory process of head and neck cancer leads to an increase the proinflammatory cytokines and the synthesis of c-reactive protein (CRP), which then causes metabolic alteration and anorexia in the patients. Zinc is one of nutrient that has an important role in suppressing inflammation, but it is reported that about 65% of head and neck cancer patients have zinc deficiency. The aim of this cross sectional study is to determine the correlation between zinc intake and serum zinc levels with CRP level as an effort in reducing inflammation process in head and neck cancer patients. Subjects were collected by consecutive sampling in the Oncology Polyclinic Rumah Sakit Kanker Dharmais, from 49 subjects 67,3% were men, most subjects were in the age range between 46–65 years. The highest frequency (65,3%) is nasopharyngeal cancer and 69,4% are already in stage IV. All subjects (100%) in this study have a zinc intake below the recommended dietary allowance (RDA) in Indonesia. The mean serum zinc level of the subjects was 9.83±2.62 μmol/L. Most subjects have elevated CRP levels. There was a weak negative correlation between zinc concentration and CRP levels of subjects (r =-0.292, p =0.042), but there was no correlation between zinc intake and CRP levels of subjects (r =-0.25).

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