Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

Kawasaki disease (KD) is an acute pediatric vasculitis that affects genetically susceptible infants and children. To identify coding variants that influence susceptibility to KD, we conducted whole exome sequencing of 159 patients with KD and 902 controls, and performed a replication study in an independent 586 cases and 732 controls. We identified five rare coding variants in five genes (FCRLA, PTGER4, IL17F, CARD11, and SIGLEC10) associated with KD (odds ratio [OR], 1.18–4.41; p = 0.0027–0.031). We also performed association analysis in 26 KD patients with coronary artery aneurysms (CAAs; diameter > 5 mm) and 124 patients without CAAs (diameter < 3 mm), and identified another five rare coding variants in five genes (FGFR4, IL31RA, FNDC1, MMP8, and FOXN1), which may be associated with CAA (OR, 3.89–37.3; p = 0.0058–0.0261). These results provide insights into new candidate genes and genetic variants potentially involved in the development of KD and CAA.

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Faculty Opinions recommendation of Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1098163.554164 ◽

2007 ◽

Author(s):

Sue Kinnamon

Keyword(s):

Gene Family ◽

Expression Pattern ◽

Receptor Gene ◽

Taste Receptor ◽

Receptor Cells ◽

Heterogenous Population ◽

Taste Receptor Cells ◽

Receptor Gene Family

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Faculty Opinions recommendation of ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1112163.568149 ◽

2008 ◽

Author(s):

Dan Lipsker

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Disease Susceptibility ◽

Functional Polymorphism ◽

Coronary Artery Aneurysms

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Genome-Wide Identification of the Gustatory Receptor Gene Family of the Invasive Pest, Red Palm Weevil, Rhynchophorus ferrugineus (Olivier, 1790)

Insects ◽

10.3390/insects12070611 ◽

2021 ◽

Vol 12 (7) ◽

pp. 611

Author(s):

Patamarerk Engsontia ◽

Chutamas Satasook

Keyword(s):

Gene Family ◽

Molecular Basis ◽

Receptor Gene ◽

Invasive Pest ◽

Effective Control ◽

Gustatory Receptor ◽

Rhynchophorus Ferrugineus ◽

Red Palm Weevil ◽

Palm Weevil ◽

Receptor Gene Family

The red palm weevil (Rhynchophorus ferrugineus) is a highly destructive pest of oil palm, date, and coconut in many parts of Asia, Europe, and Africa. The Food and Agriculture Organization of the United Nations has called for international collaboration to develop a multidisciplinary strategy to control this invasive pest. Previous research focused on the molecular basis of chemoreception in this species, particularly olfaction, to develop biosensors for early detection and more effective bait traps for mass trapping. However, the molecular basis of gustation, which plays an essential role in discriminating food and egg-laying sites and chemical communication in this species, is limited because its complete gustatory receptor gene family still has not been characterized. We manually annotated the gene family from the recently available genome and transcriptome data and reported 50 gustatory receptor genes encoding 65 gustatory receptors, including 7 carbon dioxide, 9 sugar, and 49 bitter receptors. This study provides a platform for future functional analysis and comparative chemosensory study. A better understanding of gustation will improve our understanding of this species’ complex chemoreception, which is an important step toward developing more effective control methods.

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