Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study

Background: Presence of overt proteinuria has been independently linked to greater stroke risk. The objectives of this study were to determine the relationship between the for ischemic stroke and albuminurea as a marker for vascular events. Microalbuminuria, is an early marker of both kidney disease and endothelial dysfunction, may be associated with global vascular risk, but the nature and relationship between microalbuminuria and incident ischemic stroke has not been clearly defined. The purpose of this study was to assess the association of microalbuminuria and ischemic stroke.Methods: Study enrolled 150 admitted patients of acute ischemic stroke. The patients were assessed by questionnaire, microalbuminuria, creatinine clearance after detailed history taking and thorough clinical examination.Results: The combined common risk factors were HTN (80%), diabetes (33%) and smoking (53%). The hypertensive patients had 8 times higher risk of microalbuminuria as compared to normotensive patients (95% 1.8-31.0 p<0.05). Among diabetes patients had risk of microalbuminuria 30 times higher compared to euglycemic patients (95% CL 9.6-78.8 p<0.01). The smoker patients had 8 times risk of microalbuminuria (CL 95%-1.2-22.8 p<0.16). However, the patients who had dyslipidemia had risk of microalbuminuria 1.07 times who have normal lipid level, but it was statistically insignificance (98% CL 0.8-4.1 p>0.05). The 38 patients out of 46 patients who had microalbuminuria has high normal serum creatinine with creatinine clearance (45-59 mL/min/1.73 m2. (82% versus. 4.4% 30.44 mL/min/173m2). The risk of microalbuminuria was higher in patients who had high normal serum creatinine (1.4 mg/dL) with creatinine clearance of 45-59 mL/min/1.73 m2 versus normal serum creatinine 0.8 mg/dL.Conclusions: The finding of the study, show the microalbuminuria is an independent risk factor for vascular endothelial dysfunction, in patient of diabetes early renal dysfunction and HTN, extrapolating the vascular event (ischemic stroke).

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The influence of estimated creatinine clearance on plasma homocysteine in hypertensive patients with normal serum creatinine

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2006.11.010 ◽

2007 ◽

Vol 40 (3-4) ◽

pp. 230-234 ◽

Cited By ~ 7

Author(s):

Yen-Hung Lin ◽

Kuan-Yin Pao ◽

Vin-Cent Wu ◽

Yu-Li Lin ◽

Yu-Fen Chien ◽

...

Keyword(s):

Serum Creatinine ◽

Creatinine Clearance ◽

Plasma Homocysteine ◽

Normal Serum ◽

Hypertensive Patients ◽

Normal Serum Creatinine

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CREATININE CLEARANCE (EGFR) AND RADIOCONTRAST-INDUCED NEPHROPATHY (RCIN) IN PATIENTS WITH NORMAL SERUM CREATININE LEVELS

Heart Lung and Circulation ◽

10.1016/j.hlc.2008.03.075 ◽

2008 ◽

Vol 17 ◽

pp. S32

Author(s):

S Cherian ◽

N Wijesinghe ◽

GP Devlin

Keyword(s):

Serum Creatinine ◽

Creatinine Clearance ◽

Normal Serum ◽

Normal Serum Creatinine

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Creatinine Clearance (eGFR) and Radiocontrast-induced Nephropathy (RCIN) in Patients with Normal Serum Creatinine Levels

Heart Lung and Circulation ◽

10.1016/j.hlc.2008.05.218 ◽

2008 ◽

Vol 17 ◽

pp. S91-S92

Author(s):

Sonia Cherian ◽

Namal Wijesinghe ◽

Gerard Devlin

Keyword(s):

Serum Creatinine ◽

Creatinine Clearance ◽

Normal Serum ◽

Normal Serum Creatinine

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Influence of serum iron test results on the diagnosis of iron deficiency in children: a retrospective observational study

BMJ Open ◽

10.1136/bmjopen-2020-046865 ◽

2021 ◽

Vol 11 (7) ◽

pp. e046865

Author(s):

Gorkem Sezgin ◽

Ling Li ◽

Johanna Westbrook ◽

Elisabeth Wearne ◽

Denise Azar ◽

...

Keyword(s):

Iron Deficiency ◽

Observational Study ◽

General Practitioners ◽

Serum Ferritin ◽

Serum Iron ◽

Estimating Equation ◽

Normal Serum ◽

Retrospective Observational Study ◽

Test Results ◽

General Practices

Background and objectiveSerum iron results are not indicative of iron deficiency yet may be incorrectly used to diagnose iron deficiency instead of serum ferritin results. Our objective was to determine the association between serum iron test results and iron-deficiency diagnosis in children by general practitioners.Design, setting, patients and main outcome measuresA retrospective observational study of 14 187 children aged 1–18 years with serum ferritin and serum iron test results from 137 general practices in Victoria, Australia, between 2008 and 2018. Generalised estimating equation models calculating ORs were used to determine the association between serum iron test results (main exposure measure) and iron-deficiency diagnosis (outcome measure) in the following two population groups: (1) iron-deplete population, defined as having a serum ferritin <12 µg/L if aged <5 years and <15 µg/L if aged ≥5 years and (2) iron-replete population, defined as having a serum ferritin >30 µg/L.Results3484 tests were iron deplete and 15 528 were iron replete. Iron-deplete children were less likely to be diagnosed with iron deficiency if they had normal serum iron levels (adjusted OR (AOR): 0.73; 95% CI 0.57 to 0.96). Iron-replete children had greater odds of an iron-deficiency diagnosis if they had low serum iron results (AOR: 2.59; 95% CI 1.72 to 3.89). Other contributors to an iron-deficiency diagnosis were female sex and having anaemia.ConclusionSerum ferritin alone remains the best means of diagnosing iron deficiency. Reliance on serum iron test results by general practitioners is leading to significant overdiagnosis and underdiagnosis of iron deficiency in children.

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