scholarly journals Lactate generation is not related to tissue partial pressure of oxygen levels in sepsis

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 3) ◽  
pp. P5
Author(s):  
AJ Pereira ◽  
P Rehder ◽  
C Dias ◽  
L Figueiredo ◽  
E Silva
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Nicole de Buhr ◽  
Alexander Martens ◽  
Marita Meurer ◽  
Marta C. Bonilla ◽  
Franz Söbbeler ◽  
...  

AbstractDuring infection and inflammation, a reduced oxygen level clearly affects cellular functions. Oxygen levels during CNS infections are unknown. Here we established and evaluated an in vivo measurement system to characterize the oxygen level in parallel with bacterial numbers (CFU/mL), the cell number and pH level inside the CSF of healthy compared to Streptococcus suis-infected pigs. The animals were anesthetized over a seven-hour period with isoflurane in air/oxygen at physiologic arterial partial pressure of oxygen. Oxygen levels in CSF of anesthetized pigs were compared to euthanized pigs. The detected partial pressure of oxygen in the CSF remained constant in a range of 47–63 mmHg, independent of the infection status (bacterial or cell number). In contrast, the pH value showed a slight drop during infection, which correlated with cell and bacterial number in CSF. We present physiologic oxygen and pH values in CSF during the onset of bacterial meningitis.


PEDIATRICS ◽  
1969 ◽  
Vol 43 (4) ◽  
pp. 638-639
Author(s):  
John H. Knelson ◽  
Mary Ellen Avery

The letter from Drs. Stefan, Leschin, and Gray raises the important question of the validity of measurements of the partial pressure of oxygen (PO2) in capillary blood. We concur that measurements of oxygen tension are essential in monitoring ambient oxygen levels, and we would agree that, in the absence of shock, values on capillary blood reflect the levels in arterial blood. Fortunately, data exist, at least in normal newborn infants breathing air, that permit evaluation of the usefulness of capillary samples.


Author(s):  
A. S. Farlenkov ◽  
N. A. Zhuravlev ◽  
Т. A. Denisova ◽  
М. V. Ananyev

The research uses the method of high-temperature thermogravimetric analysis to study the processes of interaction of the gas phase in the temperature range 300–950 °C in the partial pressure ranges of oxygen 8.1–50.7 kPa, water 6.1–24.3 kPa and hydrogen 4.1 kPa with La1–xSrxScO3–α oxides (x = 0; 0.04; 0.09). In the case of an increase in the partial pressure of water vapor at a constant partial pressure of oxygen (or hydrogen) in the gas phase, the apparent level of saturation of protons is shown to increase. An increase in the apparent level of saturation of protons of the sample also occurs with an increase in the partial pressure of oxygen at a constant partial pressure of water vapor in the gas phase. The paper discusses the causes of the observed processes. The research uses the hydrogen isotope exchange method with the equilibration of the isotope composition of the gas phase to study the incorporation of hydrogen into the structure of proton-conducting oxides based on strontium-doped lanthanum scandates. The concentrations of protons and deuterons were determined in the temperature range of 300–800 °C and a hydrogen pressure of 0.2 kPa for La0.91Sr0.09ScO3–α oxide. The paper discusses the role of oxygen vacancies in the process of incorporation of protons and deuterons from the atmosphere of molecular hydrogen into the structure of the proton conducting oxides La1–xSrxScO3–α (x = 0; 0.04; 0.09). The proton magnetic resonance method was used to study the local structure in the temperature range 23–110 °C at a rotation speed of 10 kHz (MAS) for La0.96Sr0.04ScO3–α oxide after thermogravimetric measurements in an atmosphere containing water vapor, and after exposures in molecular hydrogen atmosphere. The existence of proton defects incorporated into the volume of the investigated proton oxide from both the atmosphere containing water and the atmosphere containing molecular hydrogen is unambiguously shown. The paper considers the effect of the contributions of the volume and surface of La0.96Sr0.04ScO3–α oxide on the shape of the proton magnetic resonance spectra.


1981 ◽  
Vol 92 (4) ◽  
pp. 1305-1307
Author(s):  
A. Ya. Chizhov ◽  
V. G. Filimonov ◽  
Yu. M. Karash ◽  
R. B. Strelkov

2017 ◽  
Vol 16 (4) ◽  
pp. 507-518 ◽  
Author(s):  
Ivo S. Vinklárek ◽  
Marek Scholz ◽  
Roman Dědic ◽  
Jan Hála

The PpIX DF show the significant role of SOFDF mechanism at high concentrations and at atmospheric partial pressure of oxygen and should be considered when developing diagnostic tools for clinical applications.


1970 ◽  
Vol 56 (1) ◽  
pp. 39-47
Author(s):  
J. Murray Young

AbstractThe biochemical mechanisms of oxygen poisoning are discussed together with the signs and symptoms produced clinically. Investigation of 35 subjects performing work (mean 02 consumption 1.4 l./min) for 40 minutes in a pressure chamber at simulated depths of 20 to 47 feet of sea water showed that this degree of exercise markedly reduced the oxygen exposure tolerance of the subjects. This investigation also showed that rapid decompression of subjects breathing oxygen can produce an exacerbation of existing symptoms and these results are discussed.It is stressed that any breathing mixture containing a partial pressure of oxygen in excess of 150 torr constitutes an environment which is hyperbaric with respect to oxygen and caution is advised in the administration of oxygen to any patient.


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